Rchr
J-GLOBAL ID:200901093816490371   Update date: Feb. 01, 2024

Toba Hiroe

トバ ヒロエ | Toba Hiroe
Affiliation and department:
Job title: Assistant professor
Research field  (3): Pathobiochemistry ,  Physiology ,  Pharmacology
Research keywords  (14): myocardial infarction ,  cardiac aging ,  renal diseases ,  pharmacotherapeutics ,  extracellular matrix ,  aging ,  physiology ,  cardiovascular pharmacology ,  common diseases ,  atherosclerosis ,  vascular injury ,  Common disease ,  Endothelial function ,  CKD
Research theme for competitive and other funds  (9):
  • 2022 - 2027 SPARC関連細胞外マトリックスとマトリックス分解酵素からの動脈硬化治療ターゲットの探索
  • 2021 - 2024 anti-atherosclerotic effects of erythropoietin
  • 2021 - 2022 動脈硬化治療薬開発を目指した細胞外マトリックス研究
  • 2018 - 2021 慢性腎臓病増悪因子としての細 胞外マトリックスの役割
  • 2016 - 2017 慢性腎臓病治療ターゲット探索のための細胞外マトリックスの役割の検討
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Papers (46):
  • Miyuki Kobara, Tatsuya Shiraishi, Kazuki Noda, Hiroe Toba, Tetsuo Nakata. Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats. Journal of cardiovascular translational research. 2023
  • Miyuki Kobara, Toshihiro Amano, Hiroe Toba, Tetsuo Nakata. Nicorandil Suppresses Ischemia-Induced Norepinephrine Release and Ventricular Arrhythmias in Hypertrophic Hearts. Cardiovascular drugs and therapy. 2023. 37. 1. 53-62
  • Miyuki Kobara, Hiroe Toba, Tetsuo Nakata. Roles of autophagy in angiotensin II-induced cardiomyocyte apoptosis. Clinical and experimental pharmacology & physiology. 2022. 49. 12. 1342-1351
  • Yusuke Watanabe, Naseratun Nessa, Hiroe Toba, Miyuki Kobara, Tetsuo Nakata. Angelica acutiloba Exerts Antihypertensive Effect and Improves Insulin Resistance in Spontaneously Hypertensive Rats Fed with a High-Fat Diet. Pharmacology. 2022. 1-9
  • Hiroe Toba, Mitsushi J. Ikemoto, Miyuki Kobara, Tetsuo Nakata. Secreted protein acidic and rich in cysteine (SPARC) and a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) increments by the renin-angiotensin system induce renal fibrosis in deoxycorticosterone acetate-salt hypertensive rats. European Journal of Pharmacology. 2022. 914. 174681-174681
more...
MISC (124):
  • Miyuki Kobara, Hiroe Toba, Tetsuo Nakata. Caloric restriction, reactive oxygen species, and longevity. Aging. 2020. 11-18
  • Miyuki Kobara, Nessa Naseratun, Yuusuke Watanabe, Hiroe Toba, Tetsuo Nakata. Comparison of the effects of bisoprorol and atenorol on post-infarct cardiac remodeling. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 3-O
  • H Toba, A Yamaoka, S Sakurai, Y Tanaka, A Miyamoto, N Nessa, Y Watanabe, M Kobara, T Nakata. P713Short term treatment of a low dose erythropoietin improves vascular function in a rat model of insulin resistance. European Heart Journal. 2019. 40. Supplement_1
  • M Kobara, N Naseratun, Y Watanabe, H Toba, T Nakata. P6275Role of autophagy in imatinib-induced cardiotoxicity. European Heart Journal. 2019. 40. Supplement_1
  • M Kobara, N Naseratun, Y Watanabe, H Toba, T Nakata. P1603Nicorandil suppresses ischemia-induced cardiac interstitial norepinephrine enhancement and ventricular arrhythmia in hypertrophic hearts. European Heart Journal. 2019. 40. Supplement_1
more...
Books (2):
  • Inflammation in Heart Failure
    Academic Press 2015
  • Somatic stem cells and cardiac regeneration. Pathophysiological and Biochemical Analyses of “Life-Style Related or Intractable Diseases”
    Target Validation for Drug Therapy 2006
Lectures and oral presentations  (192):
  • 高血圧性臓器障害増悪因子としての細胞外マトリックスとプロテアーゼの役割
    (第28回日本病態プロテアーゼ学会学術集会 2023)
  • 理系のすすめ
    (高校生対象模擬講義 2023)
  • SPARC is induced at the early stage of vascular endothelial dysfunction to compensate inflammation in DOCA-salt hypertensive rats
    (The 29th Scientific Meeting of the International Society of Hypertension 2022)
  • 慢性腎臓病増悪因子としての細胞外マトリックスの役割
    (第41回公益財団法人篷庵社研究助成発表会 2022)
  • SPARC and ADAMTS1 are induced as anti-inflammatory factors at the early stage of vascular endothelial injury in DOCA-salt hypertensive rats
    (The 86th annual scientific meeting of the Japanese Circulation Society 2022)
more...
Professional career (1):
  • PhD (Kyoto Pharmaceutical University)
Committee career (2):
  • 2023/09 - 現在 日本高血圧学会 学術評議員
  • 2016 - 現在 日本薬理学会 学術評議員
Awards (2):
  • 2018/09 - The 42nd Annual Scientific Meeting of the Japanese Society of Hypertension JSH Women Investigator’s Award
  • 2006/10 - The 21st Scientific Meeting of the International Society of Hypertension JSH Award (Young Investigators Awards and Travel Grants)
Association Membership(s) (9):
The Pharmaceutical Society of Japan ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  Japanese Association of Cardiovascular Pharmacology ,  JAPANESE CIRCULATION SOCIETY ,  THE JAPANESE SOCIETY OF HYPERTENSION ,  JAPANESE SOCIETY FOR CIRCULATION RESEARCH ,  American Heart Association ,  The American Physiological Society ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
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