Hayashi Yoshitaka

Affiliation and department：
Job title： Professor

Research keywords (12)： transcriptome/metabolome analyses , extracellular matrix , nuclear receptor , developmental biology , diabetes mellitus , genetics , stem cell , transcriptional regulation , cell differentiation , thyroid , pancreatic islet , endocrinology

Research theme for competitive and other funds (8)：

2018 - 2023 グルカゴンによるニコチンアミド代謝制御の生体における意義の解明研究課題
2015 - 2018 糖代謝とアミノ酸代謝のクロストークにおけるグルカゴンの役割の解明
2015 - 2017 肝臓に由来する膵島α細胞増殖制御因子の同定
2013 - 2015 膵島の発生・新生における血管神経ワイヤリング形成とリモデリングの機構の解析
2012 - 2015 褐色脂肪機能制御における内分泌系とサーチュインのクロストーク

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Papers (98)：

Hayashi Y. Glucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver. Journal of diabetes investigation. 2020
Hayashi Yoshitaka. Glutaminostatin: Another facet of glucagon as a regulator of plasma amino acid concentrations. JOURNAL OF DIABETES INVESTIGATION. 2019. 10. 6. 1391-1393
Yanyan Liu, Shin Ichi Harashima, Yu Wang, Kazuyo Suzuki, Shinsuke Tokumoto, Ryota Usui, Hisato Tatsuoka, Daisuke Tanaka, Daisuke Yabe, Norio Harada, et al. Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion. FASEB Journal. 2019. 33. 5. 6239-6253
Masatoshi Murase, Yusuke Seino, Ryuya Maekawa, Atsushi Iida, Kaori Hosokawa, Tomohide Hayami, Shin Tsunekawa, Yoji Hamada, Norihide Yokoi, Susumu Seino, et al. Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass. Journal of diabetes investigation. 2019. 10. 2. 238-250
Takeda K, Nemoto KI, Hayashi Y, Yamamoto M, Sakuta R, Kimura T, Noto H. Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy. Thyroid : official journal of the American Thyroid Association. 2019. 29. 4. 607-608

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MISC (93)：

Masatoshi Murase, Yusuke Seino, Ryuya Maekawa, Atsushi Iida, Kaori Hosokawa, Tomohide Hayami, Shin Tsunekawa, Yoji Hamada, Norihide Yokoi, Susumu Seino, et al. Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass. Journal of diabetes investigation. 2019. 10. 2. 238-250
Ryuya Maekawa, Hidetada Ogata, Masatoshi Murase, Norio Harada, Kazuyo Suzuki, Erina Joo, Akiko Sankoda, Atsushi Iida, Takako Izumoto, Shin Tsunekawa, et al. Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet-but not high-carbohydrate diet-induced weight gain. American Journal of Physiology - Endocrinology and Metabolism. 2018. 314. 6. E572-E583
Suzuki Kazuyo, Iwasaki Kanako, Murata Yuki, Harada Norio, Yamane Shunsuke, Hamasaki Akihiro, Shibue Kimitaka, Joo Erina, Sankoda Akiko, Fujiwara Yuta, et al. Distribution and hormonal characterization of primary murine L cells throughout the gastrointestinal tract. JOURNAL OF DIABETES INVESTIGATION. 2018. 9. 1. 25-32
Yoshitaka Hayashi, Yusuke Seino. *Regulation of amino acid metabolism and alpha cell proliferation by glucagon. 2018
Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, et al. Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. J Nutr Biochem. 2017. 49. 71-79

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Patents (2)：

タンパク質の生産に用いることが可能なF9胚性腫瘍細胞、およびその利用
壁側内胚葉様細胞株、及びその樹立方法、並びに分泌蛋白の製造方法

Work history (3)：

2019/04/01 - 現在 Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Professor
2007/04/01 - 2019/03/31 Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Associate professor
2005/10/01 - 2007/03/31 Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Assistant Professor

Association Membership(s) (8)：

日本生理学会 , 日本分子生物学会 , 日本病態栄養学会 , The Endocrine Society , 日本内科学会 , Japan Thyroid Association , 日本糖尿病学会 , 日本内分泌学会

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