Rchr
J-GLOBAL ID：200901095487651043   Update date: Jan. 30, 2024

Nakagome Izumi

ナカゴメ イズミ | Nakagome Izumi
Affiliation and department：
Kitasato University School of Pharmaceutical Sciences, Faculty of Pharmaceutical Technology, Laboratory of Physical Chemistry for Drug Design

About Kitasato University School of Pharmaceutical Sciences, Faculty of Pharmaceutical Technology, Laboratory of Physical Chemistry for Drug Design


Job title： research assistant
Research field  (2)： Pharmaceuticals - chemistry and drug development ,  Pharmaceuticals - analytical and physicochemistry
Research keywords  (1)： 創薬のための計算化学、医薬分子設計、コンピュータシミュレーション、定量的構造活性相関、分子動力学法、リソソーム病、ゴーシェ病、ポンペ病、ファーマコロジカルシャペロン、低分子シャペロン
Research theme for competitive and other funds  (14)：
  • 2021 - 2024 変異酵素の構造安定化に基づく機能性シャペロン化合物の創製とポンペ病治療への応用
  • 2015 - 2018 Development of in silico fragment-based drug design method for rational drug discovery
  • 2009 - 2011 In silico drug design study targeting CRK-C3G interaction for future development of anticarcinogenic agent
  • 2009 - 2011 Optimization of chitinase inhibitor with macrolide scaffold based on in silico drug discovery techniques
  • 2007 - 2008 Computer-aided rational molecular design of novel chitinase inhibitor
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Papers (31)：
  • Atsushi Kato, Izumi Nakagome, Maki Kise, Kousuke Yoshimura, Nobutada Tanaka, Robert J. Nash, George W. J. Fleet, Yota Kobayashi, Hayato Ikeda, Takuya Okada, et al. Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase. Journal of Medicinal Chemistry. 2023
  • Atsushi Kato, Izumi Nakagome, Kosuke Yoshimura, Uta Kanekiyo, Mana Kishida, Kenta Shinzawa, Tian-Tian Lu, Yi-Xian Li, Robert J. Nash, George W. J. Fleet, et al. Introduction of <i>C</i>-alkyl branches to L-iminosugars changes their active site binding orientation. Organic & Biomolecular Chemistry. 2022. 20. 36. 7250-7260
  • Atsushi Kato, Izumi Nakagome, Uta Kanekiyo, Tian-Tian Lu, Yi-Xian Li, Kosuke Yoshimura, Mana Kishida, Kenta Shinzawa, Tomoki Yoshida, Nobutada Tanaka, et al. 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease. Journal of medicinal chemistry. 2022. 65. 3. 2329-2341
  • Atsushi Kato, Izumi Nakagome, Mizuki Hata, Robert J. Nash, George W. J. Fleet, Yoshihiro Natori, Yuichi Yoshimura, Isao Adachi, Shuichi Hirono. Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity. Molecules. 2020. 25. 12. 2843-2843
  • Sarah O’Keefe, Quentin P Roebuck, Izumi Nakagome, Shuichi Hirono, Atsushi Kato, Robert Nash, Stephen High. Characterizing the selectivity of ER α-glucosidase inhibitors. Glycobiology. 2019. 29. 7. 530-542
ｍore...
MISC (9)：
  • 中込 泉, 豊岡 尚樹, 峰平 大輔, 竹田 大輔, 加藤 敦, 足立 伊左雄, 松谷 裕二, 川田 耕司, 佐藤 謙一, 山乙 教之, et al. PPARγLBDと三環系PPARγパーシャルアゴニストの相互作用解析. 日本薬学会年会要旨集. 2012. 132年会. 4. 160-160
  • Shuichi Hirono, Izumi Nakagome, Noriyuki Yamaotsu, Hiroaki Gouda. 3D-QSAR MODELS FOR THE PPARS AGONISTS WITH DUE REGARD TO MEMBRANE TRANSPORT. DRUGS OF THE FUTURE. 2009. 34. 105-105
  • 広野 修一, 中込 泉. Ligand-Based Drug Designにおける3D-QSAR : 有機カチオントランスポーター1リガンドの三次元ファーマコフォア解析と結合部位モデリング(<特集(1)>医薬品の分子設計および構造活性相関の最前線). 生物工学会誌 : seibutsu-kogaku kaishi. 2008. 86. 12. 600-603
  • H HOMMA, NAKAGOME, I, M KAMAKURA, M HIROTA, M TAKAHASHI, M MATSUI. STUDIES ON RAT HEPATIC HYDROXYSTEROID SULFOTRANSFERASE - IMMUNOCHEMISTRY, DEVELOPMENT AND PI VARIANTS. CHEMICO-BIOLOGICAL INTERACTIONS. 1994. 92. 1-3. 15-24
  • MORIGUCHI, I, S HIRONO, NAKAGOME, I, H HIRANO. COMPARISON OF RELIABILITY OF LOG-P VALUES FOR DRUGS CALCULATED BY SEVERAL METHODS. CHEMICAL & PHARMACEUTICAL BULLETIN. 1994. 42. 4. 976-978
ｍore...
Lectures and oral presentations  (31)：
  • ポンペ病原因酵素リソソーム酸性α-グルコシダーゼに対する低分子シャペロン5-C-alkyl-L-ido-DNJのアルキル鎖長が活性や結合配向に及ぼす影響
    (日本薬学会第143年会 2023)
  • 水和サイト解析を用いたGAA高親和性アロステリックシャペロンのバーチャルスクリーニング
    (日本薬学会第143年会 2023)
  • ポンぺ病の原因酵素酸性α-glucosidaseを標的とした高親和性シャペロン化合物の創製
    (日本薬学会第143年会 2023)
  • Search for allosteric chaperones for lysosomal acid α-glucosidase
    (2022)
  • In silico解析と親和性測定に基づいたlysosomal acid α-glucosidase (GAA)選択特性を有するイミノ糖のデザイン研究
    (日本薬学会第142年会 2022)
ｍore...
Education (2)：
  • - 1991 Kyoritsu University of Pharmacy Graduate School, Division of Pharmaceutical Sciences
  • - 1989 Kyoritsu University of Pharmacy Faculty of Pharmaceutical Science
Professional career (1)：
  • (BLANK)
Association Membership(s) (1)：
日本薬学会
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