Rchr
J-GLOBAL ID：200901095601049812   Update date: Sep. 28, 2024

Tsuzuki Shinobu

ツヅキ シノブ | Tsuzuki Shinobu
Affiliation and department：
Aichi Medical University School of Medicine

About Aichi Medical University School of Medicine


Job title： Laboratory Head
Research field  (1)： Hematology and oncology
Research keywords  (6)： がん遺伝子 ,  転写因子 ,  造血器腫瘍 ,  Oncogene ,  Transcription Factors ,  Hematological Malignancies
Research theme for competitive and other funds  (26)：
  • 2022 - 2026 隠れドライバーから見た、難治性リンパ性白血病の成立・維持機構の解明
  • 2020 - 2023 脂肪組織由来間葉系幹細胞-造血幹細胞における代謝経路解析:抗加齢作用に注目して
  • 2018 - 2021 Deciphering leukemia development and maintenance from the perspective of functions of fusion genes
  • 2015 - 2018 Investigation of mechanisms underlying the development of lymphoma and myeloma using a high-throughput mouse model system
  • 2010 - 2012 Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemia
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Papers (98)：
  • Mina Noura, Sakura Tomita, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa. NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation. Cancer medicine. 2024. 13. 13. e7445
  • Chiharu Yamada, Kentaro Okada, Koya Odaira, Mahiru Tokoro, Eisuke Iwamoto, Masashi Sanada, Mina Noura, Syuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, et al. RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins. Cancer medicine. 2024. 13. 14. e7471
  • Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, et al. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell death discovery. 2024. 10. 1. 56-56
  • Mina Noura, Hidemasa Matsuo, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa. Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. Oncogene. 2023
  • Toshinori Hyodo, Eri Asano-Inami, Satoko Ito, Mai Sugiyama, Akihiro Nawa, Md Lutfur Rahman, Muhammad Nazmul Hasan, Yuko Mihara, Vu Quang Lam, Sivasundaram Karnan, et al. Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis. The FEBS Journal. 2023
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MISC (68)：
  • 太田明伸, 太田明伸, 花村一朗, シバスンダラン カルナン, シバスンダラン カルナン, 武井則雄, IFTEKHAR Chowdhury Sajid, 兵頭寿典, 小西裕之, 都築忍, et al. A novel FIRRM-FIGNL1 interaction enhances the viability of multiple myeloma cells. International Journal of Myeloma (Web). 2024. 14. 3
  • HYODO Toshinori, HASAN Muhammad Nazmul, BISWAS Mrityunjoy, INAMI Eri, KARNAN Sivasundaram, OTA Akinobu, TSUZUKI Shinobu, HOSOKAWA Yoshitaka, KONISHI Hiroyuki. LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
  • HASAN Muhammad Nazmul, HYODO Toshinori, BISWAS Mrityunjoy, RAHMAN MD. Lutfur, MIHARA Yuko, KARNAN Sivasundaram, OTA Akinobu, TSUZUKI Shinobu, HOSOKAWA Yoshitaka, KONISHI Hiroyuki. A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
  • 太田明伸, 太田明伸, カルナン シバスンダラン, 小西裕之, 都築忍, 細川好孝, 風岡宜暁. OTS514 suppresses the tumor growth with concomitant downregulation of E2F target genes in oral squamous carcinoma cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 山田千晴, 岡田健太郎, 大平晃也, 村木愛実, 能浦三奈, 岡本修一, 安田貴彦, 都築忍, 早川文彦. ZNF384融合蛋白転写標的の探索. 日本血液学会学術集会抄録(Web). 2023. 85th
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Patents (4)：
  • MEF2D融合型旧制リンパ性白血病を治療するための医薬組成物
  • MEF2D融合型旧制リンパ性白血病を治療するための医薬組成物
  • METHOD FOR DETERMINING PRESENCE OR ABSENCE OF SUFFERING FROM MALIGNANT LYMPHOMA OR LEUKEMIA, AND AGENT FOR TREATMENT AND/OR PREVENTION OF LEUKEMIA
  • 悪性リンパ腫又は白血病の罹患の有無の判定方法並びに白血病の治療及び/又は予防のための薬剤
Education (1)：
  • - 1987 Nagoya University School of Medicine
Professional career (1)：
  • Doctor of Medical Science (Nagoya University)
Work history (10)：
  • 2017/04 - 現在 Aichi Medical University School of Medicine Professor
  • 2016/07 - 2017/03 Aichi Medical University School of Medicine Associate Professor
  • 2005/04 - 2016/06 Aichi Cancer Center, Research Institute Chief Researcher
  • 2001/09 - 2005/03 Aichi Cancer Center, Research Institute Senior Researcher
  • 1998/11 - 2001/08 Institute of Cancer Research, UK
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Awards (1)：
  • 2004 - 日本白血病研究基金研究助成事業・一般研究賞
Association Membership(s) (4)：
米国血液学会 ,  日本内科学会 ,  日本血液学会 ,  日本癌学会
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