Rchr
J-GLOBAL ID:200901095601049812
Update date: Apr. 07, 2024
Tsuzuki Shinobu
ツヅキ シノブ | Tsuzuki Shinobu
Affiliation and department:
Job title:
Laboratory Head
Research field (1):
Hematology and oncology
Research keywords (6):
がん遺伝子
, 転写因子
, 造血器腫瘍
, Oncogene
, Transcription Factors
, Hematological Malignancies
Research theme for competitive and other funds (26):
- 2022 - 2026 隠れドライバーから見た、難治性リンパ性白血病の成立・維持機構の解明
- 2020 - 2023 脂肪組織由来間葉系幹細胞-造血幹細胞における代謝経路解析:抗加齢作用に注目して
- 2018 - 2021 Deciphering leukemia development and maintenance from the perspective of functions of fusion genes
- 2015 - 2018 Investigation of mechanisms underlying the development of lymphoma and myeloma using a high-throughput mouse model system
- 2010 - 2012 Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemia
- 2005 - 2009 Molecular mechanisms of lymphomagenesis
- 2007 - 2008 Modeling human leukemia/lymphoma, and ex vivo expansion of hematopoietic stem cells and granulocytes
- 2006 - 2007 siRNA/がん遺伝子デュアル発現システムによる新規発がん機構の解明
- 2005 - 2006 Analysis of multi-step processes of leukemia-genesis in childhood leukemia.
- 2003 - 2004 Roles of GATA-2/retinoic acid receptor pathways and TEL-AML1 translocation in leukemia
- 2002 - 2003 Roles of translocation junction genes for proliferation and differentiation of hemotolymphoid cell
- 1998 - 1999 Establishment of Ryudocan Null Mouse and ELISA for Blood Levels of Ryudocan
- 1998 - 1999 Ryudocan expression and its regulation
- 1998 - 1999 老化と血栓症:老化モデルマウスでは血液凝固線溶因子の組織内発現異常が存在するか?
- 1998 - 1998 動脈硬化の発症病態に関わるHSPG・Ryudocanの機能解析
- 1998 - 1998 転写因子とcofactorによる造血幹細胞分化モデル:GATA-2とPMLの結合
- 1997 - 1998 Development of Immunogene Therapy for B-cell malignancy
- 1998 - がん遺伝子
- 1998 - 血液の増殖、分化
- 1998 - 造血器腫瘍の発生機構
- 1998 - Oncogenes
- 1998 - Proliferation and differentiation of hematopoietic cells
- 1998 - Mechanisms of Malignant hematopoiesis
- 1997 - 1997 造血幹細胞においてGATA-2遺伝子産物と機能的に結合する蛋白の分離同定
- 1996 - 1997 Molecular and Functional Analysis of Heparan sulfate Proteoglycan-Ryudocan.
- 造血器腫瘍の分子病態
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Papers (100):
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Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, et al. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell death discovery. 2024. 10. 1. 56-56
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Mina Noura, Hidemasa Matsuo, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa. Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. Oncogene. 2023
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Mina Noura, Takahiko Yasuda, Shinobu Tsuzuki, Hidemasa Matsuo, Hitoshi Kiyoi, Fumihiko Hayakawa. Suppression of Super-Enhancer-Driven TAL1 Expression By KLF4 in T-Cell Acute Lymphoblastic Leukemia. Blood. 2023. 142. Supplement 1. 1405-1405
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Toshinori Hyodo, Eri Asano-Inami, Satoko Ito, Mai Sugiyama, Akihiro Nawa, Md Lutfur Rahman, Muhammad Nazmul Hasan, Yuko Mihara, Vu Quang Lam, Sivasundaram Karnan, et al. Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis. The FEBS Journal. 2023
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Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md. Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Lam Quang Vu, Ichiro Hanamura, Akihito Inoko, Miho Riku, et al. CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma. Cell Death Discovery. 2023
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MISC (59):
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山田千晴, 岡田健太郎, 大平晃也, 村木愛実, 能浦三奈, 岡本修一, 安田貴彦, 都築忍, 早川文彦. ZNF384融合蛋白転写標的の探索. 日本血液学会学術集会抄録(Web). 2023. 85th
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Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. CANCER SCIENCE. 2022. 113. 1236-1236
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都築忍, 安田貴彦, 河津正人, 上野敏秀, シバスンダラン カルナン, 太田明伸, 真田昌, 永井宏和, 冨田章裕, 高橋義行, et al. Pre-B細胞性急性リンパ球性白血病における転写制御ネットワーク. 日本癌学会学術総会抄録集(Web). 2021. 80th
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シバスンダラン・カルナン, 太田 明伸, 花村 一朗, 村上 秀樹, 兵頭 寿典, 小西 裕之, 都築 忍, 細川 好孝. p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Establishment and characterization of human mesothelial cell lines with CRISPR/Cas9-mediated disruption of NF2 and p16). 日本癌学会総会記事. 2019. 78回. P-1221
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Sivasundaram Karnan, 太田 明伸, 兵頭 寿典, 小西 裕之, 都築 忍, 細川 好孝. CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3P-277]
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Patents (4):
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MEF2D融合型旧制リンパ性白血病を治療するための医薬組成物
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MEF2D融合型旧制リンパ性白血病を治療するための医薬組成物
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METHOD FOR DETERMINING PRESENCE OR ABSENCE OF SUFFERING FROM MALIGNANT LYMPHOMA OR LEUKEMIA, AND AGENT FOR TREATMENT AND/OR PREVENTION OF LEUKEMIA
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悪性リンパ腫又は白血病の罹患の有無の判定方法並びに白血病の治療及び/又は予防のための薬剤
Education (1):
- - 1987 Nagoya University School of Medicine
Professional career (1):
- Doctor of Medical Science (Nagoya University)
Work history (10):
- 2017/04 - 現在 Aichi Medical University School of Medicine Professor
- 2016/07 - 2017/03 Aichi Medical University School of Medicine Associate Professor
- 2005/04 - 2016/06 Aichi Cancer Center, Research Institute Chief Researcher
- 2001/09 - 2005/03 Aichi Cancer Center, Research Institute Senior Researcher
- 1998/11 - 2001/08 Institute of Cancer Research, UK
- 1995/08 - 1998/10 名古屋大学医学部附属病院 輸血部 医員
- 1992/07 - 1995/07 東京都立駒込病院 化学療法科/輸血科 医師
- 1992/04 - 1992/06 国立豊橋病院 内科 医師
- 1989/04 - 1992/03 名古屋第一赤十字病院 内科 医師
- 1987/04 - 1989/03 名古屋第一赤十字病院 臨床研修医
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Awards (1):
- 2004 - 日本白血病研究基金研究助成事業・一般研究賞
Association Membership(s) (4):
米国血液学会
, 日本内科学会
, 日本血液学会
, 日本癌学会
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