Ichinose Masakazu

• 2016 - 2019 COPD合併喘息の酸化窒素化制御による新規治療剤開発に関する研究
• 2016 - 2019 慢性閉塞性肺疾患に対する新規炎症制御法の確立に関する研究
• 2015 - 2018 COPD合併喘息の新規治療法開発等に関する研究
• 2008 - 2011 気道炎症モニタリングの一般臨床応用化:新しい喘息管理目標の確立に関する研究
• 2007 - 2008 呼気凝縮液を用いた気管支喘息の気道炎症評価法の確立と臨床応用に関する研究
2002 - 2003 慢性閉塞性肺疾患病態へのDNA損傷の関与の検討とその修復機序解明による治療法開発
2000 - 2002 慢性閉塞性肺疾患の炎症制御機構の解明及び新しい炎症マーカーの開発
1999 - 2000 誘導型一酸化窒素合成酵素欠損マウスを用いた喘息・慢性気管支炎の発症・増悪因子解明
1998 - 1999 パーオキシナイトライトの肺・気道傷害機序の解明:炎症性疾患の新治療をめざして
1996 - 1997 ヒト気道においてIgEが興奮性神経機能亢進をきたす機序の研究
1992 - 1993 神経原性気道炎症の慢性モデルによる検討とヒト気道でのAxon reflexの証明
Future therapy for bronchial asthma
Pathophysiology and therapy of COPD
role of NO in pulmonary disease
Allergic inflammation and autonomic nervous system
Airway neurogenic inflammation

• Yanagisawa S, Mitsune A, Ichinose M. Right-to-left pulmonary shunt through arteriovenous malformation. Medicina clinica. 2018. 151. 7. 297-297
• Ferguson GT, Rabe KF, Martinez FJ, Fabbri LM, Wang C, Ichinose M, Bourne E, Ballal S, Darken P, DeAngelis K, et al. Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary disease (KRONOS): a double-blind, parallel-group, multicentre, phase 3 randomised controlled tr. The Lancet. Respiratory medicine. 2018. 6. 10. 747-758
• Taizou Hirano, Akira Koarai, Tomohiro Ichikawa, Teruyuki Sato, Takashi Ohe, Masakazu Ichinose. Possible involvement of interleukin-18 in the pathology of hepatobiliary adverse effects related to treatment with ceritinib. BMC CANCER. 2018. 18. 1. 995
• Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Okazaki T, Sugiura H, Ichinose M. TLR7 agonist attenuates acetylcholine-induced, Ca²⁺ -dependent ionic currents in swine tracheal submucosal gland cells. Experimental physiology. 2018. 103. 11. 1543-1559
• Hirano T, Fujino N, Takase K, Ota H, Tanaka R, Saito R, Suzuki A, Okutomo K, Sato T, Kageyama S, et al. Pulmonary Lymphatic Perfusion Syndrome. American journal of respiratory and critical care medicine. 2018. 199. 4. 529-530

ｍore...

• Gen Tamura, Masakazu Ichinose, Yoshinosuke Fukuchi, Terumasa Miyamoto. Transdermal Tulobuterol Patch, a Long-Acting beta(2)-Agonist. ALLERGOLOGY INTERNATIONAL. 2012. 61. 2. 219-229
• Hisatoshi Sugiura, Hiroki Kawabata, Tomohiro Ichikawa, Akira Koarai, Satoru Yanagisawa, Takashi Kikuchi, Yoshiaki Minakata, Kazuto Matsunaga, Masanori Nakanishi, Tsunahiko Hirano, et al. Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012. 302. 8. L764-L774
• Hisatoshi Sugiura, Akira Koarai, Tomohiro Ichikawa, Yoshiaki Minakata, Kazuto Matsunaga, Tsunahiko Hirano, Keiichiro Akamatsu, Satoru Yanagisawa, Makoto Furusawa, Yumiko Uno, et al. Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease. RESPIROLOGY. 2012. 17. 3. 533-540
• Masaharu Kinoshita, Sang Haak Lee, Liang-Wen Hang, Masakazu Ichinose, Motoi Hosoe, Naoko Okino, Niyati Prasad, Benjamin Kramer, Yoshinosuke Fukuchi. Efficacy and safety of indacaterol 150 and 300 mu g in chronic obstructive pulmonary disease patients from six Asian areas including Japan: A 12-week, placebo-controlled study. RESPIROLOGY. 2012. 17. 2. 379-389
• Increase of 27- hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27- hydroxycholesterol in tissue fibrosis. Chest. 2012

ｍore...

• Antiallergic drugs.
  Drugs for the Treatment of Respiratory Diseases. Cambridge University Press, Cambridge 2003
• Antiallergic drugs.
  Drugs for the Treatment of Respiratory Diseases. Cambridge University Press, Cambridge 2003
• Bronchoconstriction after oral allergen challenge in sensitized guinea pigs.
  Advances in Asthmology 1991
• Histamine H₃-receptors : function in airways.
  Advances in Asthmology 1991
• Bronchoconstriction after oral allergen challenge in sensitized guinea pigs.
  Advances in Asthmology 1991

ｍore...

• - 1980 Tohoku University Faculty of Medicine
• - 1980 Tohoku University Faculty of Medicine

• Doctor of Medicine (Tohoku University)

• 2012/05 - 現在 Departent of Respiratory Medicine, Tohoku University Graduate School of Medicine Professor
• 2003/05 - 2012/04 - 和歌山県立医科大学 医学部 教授
• 2002 - 2003 東北大学大学院 助教授
• 2002 - 2003 Assosiate Professor of Tohoku Graduate School of Medicine
• 2003 - - Professor of Medicine, Wakayama Medical University
2001 - 2002 東北大学大学院 講師
2001 - 2002 Assistant Professor of Tohoku Graduate School of Medicine
1990 - 2001 Tohoku University
1990 - 2001 Research fellow of Tohoku University School of Medicine
1988 - 1990 英国立心肺研究所 研究員
1988 - 1990 Visiting Researcher of National Heart & Lung Institute(UK)
1982 - 1988 東北大学医学部第一内科
1982 - 1988 First Department of Internal Medicine,
Tohoku University School of Med.

• 2003 - 2004 Nitric Oxide Society of Japan Director
• 日本NO学会 理事、企画委員、評議員
• 日本アレルギー学会 代議員、プログラム委員
• 日本呼吸器学会 代議員、肺生理専門委員会副委員長、プログラム委員
• 日本内科学会 評議員

• 2003 - 東北大学医学部奨励賞金賞
• 2003 - Gold Prize of Tohoku University School of Medicine
• 2001 - アストラゼネカ喘息研究奨励賞
• 1999 - 日本呼吸器学会「熊谷」賞
• 1999 - Kumagai Award (Japanese Respiratory Society)
1996 - 北陸製薬・アレルギー学術奨励賞
1996 - Japanese Society of Allergology Award
1994 - 日本胸部疾患学会奨励賞
1994 - Young Investigator Award (Japanese Respiratory Society)

日本NO学会 ,  国際エアロゾル医学会(Society of Aerosols in Medicine) ,  ヨーロッパ呼吸器学会(European Respiratory Society) ,  米国胸部疾患学会(American Thoracic Society) ,  日本アレルギー学会 ,  日本呼吸器学会 ,  日本内科学会 ,  Nitric Oxide Society of Japan ,  European Respiratory Society (ERS) ,  American Thoracic Society (ATS) ,  Japanese Society of Allergology ,  Japanese Respiratory Society ,  Japanese Society of Internal Medicine