Research field (3):
Physiology
, Neuroscience - general
, Neuroanatomy and physiology
Research keywords (5):
Autism spectrum disorder
, in vivo イメージング
, カルシウム
, 樹状突起スパイン
, 樹状突起
Research theme for competitive and other funds (9):
2022 - 2025 Two-photon microscopy of the pathophysiology of synapses in animal models of autism spectrum disorder
2018 - 2021 Alterations in synaptic stability and trials of their adjustment in autism model marmosets
2014 - 2017 Analysis of the properties of synaptic back propagating signal
2014 - 2016 脳内環境がスパイン形態可塑性に与える影響の解析
2009 - 2014 Cerebral spine synapses and exocytosis studied with two-photon microscope
2009 - 2012 シナプス可塑性のin vivo誘導とその応用
2009 - 2011 Development of an in vivo induction method of synaptic plasticity.
2007 - 2009 in vivo神経回路網可塑性解析法の開発
2007 - 2008 Development of in vivo methods for studying neural circuit plasticity
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Papers (29):
Hasan Ucar, Satoshi Watanabe, Jun Noguchi, Yuichi Morimoto, Yusuke Iino, Sho Yagishita, Noriko Takahashi, Haruo Kasai. Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis. Nature. 2021. 600. 7890. 686-689
Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, et al. Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease. Nature communications. 2021. 12. 1. 5388-5388
Noguchi, J, Nagaoka A, Hayama, T, Ucar H, Yagishita, S, Takahashi, N, Kasa, H. Bidirectional in vivo dendritic spine plasticity revealed by two-photon glutamate uncaging in the mouse neocortex. Sci Rep. 2019. 9. 1. 13922-13922
Akira Nagaoka, Hiroaki Takehara, Akiko Hayashi-Takagi, Jun Noguchi, Kazuhiko Ishii, Fukutoshi Shirai, Sho Yagishita, Takanori Akagi, Takanori Ichiki, Haruo Kasai. Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo. SCIENTIFIC REPORTS. 2016. 6. 26651