Chosa Naoyuki

チョウサナオユキ | Chosa Naoyuki

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://cellbiosignal.jp/

Research field (4)： Oral medicine , Medical biochemistry , Molecular biology , Cell biology

Research keywords (10)： inflammation , 免疫 , 受容体 , 間葉系幹細胞 , 分化 , シグナル伝達 , 遊走 , サイトカイン , ケモカイン , 幹細胞

Research theme for competitive and other funds (23)：

2024 - 2028 Establishment of therapy involving tissue regeneration using anti-inflammatory peptide derived from mesenchymal stem cells
2023 - 2027 口腔扁平上皮癌細胞の癌微小環境における細胞外小胞を介した浸潤・転移誘導機構の解明
2020 - 2024 間葉系幹細胞由来ペプチドを利用した炎症抑制と組織再生の両立を実現する治療法の確立
2020 - 2023 口腔癌微小環境における間葉系幹細胞を司令塔とした癌浸潤・転移誘導メカニズムの解明
2016 - 2020 The construction of new therapeutic strategy of functionally graded nanohybrid implant using dental pulp stem cells

2016 - 2020 Establishment of cell therapy for periodontitis accompanied by tissue regeneration utilizing anti-inflammatory peptide secreted by mesenchymal stem cells

2016 - 2020 間葉系幹細胞が分泌する炎症抑制ペプチドを用いた組織再生を伴う歯周炎治療法の確立

2016 - 2020 歯髄幹細胞を応用した傾斜機能型ナノハイブリッドインプラントの新治療戦略の構築

2017 - 2019 Establishment of novel therapy for intractable necrosis of the jaw with mesenchymal stem cells-induced anti-inflammatory macrophages

2017 - 2019 間葉系幹細胞の抗炎症性マクロファージ誘導機構を応用した難治性顎骨壊死新規治療戦略

2013 - 2016 Analysis for homing mechanism of mesenchymal stem cells on functionally graded nanohybrid titanium dental implant

2013 - 2016 Elucidating the molecular mechanism of a peptide, SCRG1, derived from mesenchymal stem cells to suppress the osteoclast differentiation.

2013 - 2016 Study of periodontal tissue regeneration by mesenchymal stem cells with enhanced anti-inflammatory effects.

2012 - 2015 Relationship between development of Hertwig's epithelial root sheath and molecular mechanism that controls cell migration.

2012 - 2013 AP-1によるカテプシン産生制御に着目した歯肉増殖症・歯周病診断の新機軸

2010 - 2012 Suppression of anoikis by galectin-1 in human oral squamous cell carcinoma cells

2008 - 2010 Elucidation of relationship between indole produced in periodontopathogenic bacteria and periodontal disease

2007 - 2008 Regulation of integrin signaling by a cystein-rich peptide, SCRG1, in mesenchymal stem cells

2006 - 2007 Analysis of interaction of tumor suppressor gene, Nm23, with molecular chaperon in an oral cancer cell

2005 - 2006 細胞外に存在する分子シャペロンは間葉系幹細胞の増殖や分化を制御する

2004 - 2005 Molecular chaperon HSP regulates apoptosis signaling

2002 - 2003 Involvement molecular chaperone in apoptosis signaling in human salivary gland cell line

2000 - 2001 Interaction between signaling molecules and HSP90 on apoptosis pathway in HSG cells

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Papers (63)：

Hironori Yoshida, Seiji Yokota, Kazuro Satoh, Akira Ishisaki, Naoyuki Chosa. Connective tissue growth factor enhances TGF-β1-induced osteogenic differentiation via activation of p38 MAPK in mesenchymal stem cells. Journal of oral biosciences. 2024. 66. 1. 68-75
Kanna Asanuma, Seiji Yokota, Naoyuki Chosa, Masaharu Kamo, Miho Ibi, Hisayo Mayama, Tarou Irié, Kazuro Satoh, Akira Ishisaki. Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint. Journal of oral biosciences. 2023. 65. 1. 97-103
Seiji Yokota, Naoyuki Chosa, Shikino Matsumoto, Kazuro Satoh, Akira Ishisaki. Extracellular adenosine 5'-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes. Molecular biology reports. 2023. 50. 2. 1595-1602
Miyamae Y, Ohta M, Sato K, Ishisaki A, Chosa N. TGF-β1-induced IL-6 expression via MEK pathway in mesenchymeal stem cells enhances NGF-dependent neurite extension in PC12 cells. Dental Journal of Iwate Medical University,. 2022. 47. 1. 19-33
Shikino Matsumoto, Seiji Yokota, Naoyuki Chosa, Seiko Kyakumoto, Hitomichi Kimura, Masaharu Kamo, Kazuro Satoh, Akira Ishisaki. Receptor tyrosine kinase ligands and inflammatory cytokines cooperatively suppress the fibrogenic activity in temporomandibular-joint-derived fibroblast-like synoviocytes via mitogen-activated protein kinase kinase/extracellular signal-regulated kinase. Experimental and therapeutic medicine. 2020. 20. 3. 1967-1974

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MISC (181)：

帖佐直幸, 横田聖司, 吉田弘法, 横田潤, 菊池恵美子, 佐藤和朗, 石崎明. 間葉系幹細胞の骨芽細胞分化における成長因子の影響. 岩手医科大学歯学雑誌. 2024. 49. 1. 25-26
平野大輔, 加茂政晴, 横田聖司, 帖佐直幸, 石崎明, 山田浩之. 口腔潜在的悪性疾患におけるHippo経路を介したSox9シグナル伝達機構の解明と予後予測評価これまでの研究成果報告と今後の展望. 岩手医科大学歯学雑誌. 2023. 48. 2. 56-57
吉田弘法, 阿部カレン, 浅沼莞奈, 菊池恵美子, 横田聖司, 石崎明, 帖佐直幸, 佐藤和朗. CTGFはTGF-βにより誘導される間葉系幹細胞の骨芽細胞分化を増強する. 日本矯正歯科学会大会プログラム・抄録集. 2023. 82回. 197-197
阿部カレン, 横田聖司, 浅沼莞奈, 吉田弘法, 間山寿代, 帖佐直幸, 佐藤和朗, 石崎明. 変形性顎関節症において発現誘導される炎症性サイトカインの網羅的解析研究. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-328]
吉田弘法, 阿部カレン, 浅沼莞奈, 菊池恵美子, 横田聖司, 石崎明, 佐藤和朗, 帖佐直幸. 間葉系幹細胞におけるTGF-β誘導性の骨芽細胞分化に対するCTGFの促進的作用について. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-377]

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Books (2)：

Interface oral health science 2011.
Springer 2012 ISBN:9784431540694
Interface oral health science 2011
Springer 2012

Education (1)：

- 2000 Hokkaido University Faculty of Environmental Earth Science

Professional career (1)：

Ph.D (Hokkaido University)

Work history (6)：

2018/04 - 現在 Iwate Medical University
2016/04 - 2018/03 Iwate Medical University
2013/07 - 2016/03 Iwate Medical University
2011/04 - 2013/06 Iwate Medical University
2007/04 - 2011/03 Iwate Medical University School of Dentistry

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Committee career (3)：

2020 - 現在 Experimental and Therapeutic Medicine Editorial Board member
2019 - 現在 Molecular Medicine Reports Editorial Board member
2016 - 現在岩手医科大学歯学雑誌編集委員

Association Membership(s) (5)：

JAPANESE ASSOCIATION FOR ORAL BIOLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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