Rchr
J-GLOBAL ID：200901096494983503
Update date: Nov. 06, 2024
Wada Takehiko
ワダ タケヒコ | Wada Takehiko
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
http://www2.tagen.tohoku.ac.jp/lab/wada/
,
http://db.tagen.tohoku.ac.jp/php/forweb/outline.php?lang=en&no=1035
Research field (7)：
Basic physical chemistry
, Polymer materials
, Polymer chemistry
, Biochemistry
, Bioorganic chemistry
, Structural/physical organic chemistry
, Polymer chemistry
Research keywords (5)：
Supramolecular Chemistry
, Functional Polymer Science
, Organic Photochemistry
, Nucleic Acid Chemistry
, Bioorganic Chemistry
Research theme for competitive and other funds (46)：
- 2023 - 2028 Construction of Artificial Nucleic Acids with Highly Active Catalytic Target RNA Cleavage Ability and Development as a Therapeutic Platform
- 2022 - 2027 Interaction between material and helical near field
- 2023 - 2026 高活性触媒的標的RNA切断機能付与型人工核酸の構築と新興感染症等治療基盤の創製
- 2021 - 2023 Development of high-sensitivity time-resolved CD measuring system for elucidation of functional biopolymers dynamics
- 2021 - 2022 Application of novel chimeric oligonucleotide therapeutics for COVID-19 treatment platform with remarkably enhanced catalytic target RNA cleavage activities
- 2019 - 2021 Creation of novel strategy for asymmetric photochirogenesis mediated by asymmetric coordination space scaffolded by biopolymer
- 2018 - 2021 Development of novel therapies for diabetic nephropathy based on the maintenance of differentiation in podocytes
- 2018 - 2020 Development of a circular dichroism measuring system with high sensitivity and high time-resolution and its application for creation of biofunctional materials
- 2017 - 2020 Development of a Heteroduplex Oligonucleotide Targeting MicroRNAs For Ischemic Stroke
- 2016 - 2019 Study of the molecular mechanism of podocyte protection effect with the vitamin D receptor and establishment of the new treatment base
- 2016 - 2019 Supramolecular Asymmetric Photochirogenesis with Biopolymers as Chiral Reaction Media
- 2015 - 2018 Metabolic Reprogramming and Hypoxic Memory in Kidney Disease
- 2015 - 2018 Establishment of whole exome sequencing for the diagnosis of atypical hemolytic uremic syndrome
- 2015 - 2018 Mechanisms of maintenance of podocyte cytoskeletal structure against metabolic stress associated with diabetes and Development of novel therapeutic strategies
- 2014 - 2017 Regulation of hypoxia inducible genes in chronic kidney disease
- 2014 - 2017 Development of Ischemia-Specific Oligonucleotide Therapeutics System for Acute stroke
- 2012 - 2017 Dynamics of biomimetic hierarchical structure
- 2013 - 2016 Identification of microRNA that regulates renal pathophysiology related to hypoxia and ER stress
- 2013 - 2016 The analysis of the pathophysiology of the Kidney- Gut interaction, the vicious cycle in Chronic kidney disease and dysbiosis.
- 2013 - 2016 Sensitivity improvement of Elliptically-polarization-detected CD spectroscopy for the drug-biomolecule binidng study
- 2010 - 2016 Comprehensive Research on Fusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control
- 2012 - 2015 Elucidation of the pathogenesis of kidney disease via epigenetic responses against hypoxia
- 2012 - 2015 Elucidation of the mechanisms of podocyte homeostasis and development of new therapeutic strategies against diabetic kidney disease
- 2012 - 2015 Supramolecular Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate with Proteins and Protein-Polymer Hybrids as Chiral Reaction Medias
- 2011 - 2013 生体高分子の有するソフトインタフェースを活用した新奇超分子不斉光化学反応系の構築
- 2011 - 2012 Synthesis of Self-Replicating Peptide Ribonucleic Acid (PRNA) System withClick Chemistry
- 2009 - 2012 生体高分子を足場とするソフトインターフェースを活用した超分子不斉光反応系の創製
- 2009 - 2011 Studies on Noble Methodology of Supramolecular Photochirogenesis with Biopolymers as a Chiral Reaction Media
- 2009 - 2011 クリックケミストリーを活用した自己複製・増幅能を有するナノバイオシステムの創製
- 2006 - 2008 Studies on Supramolecular Photochirogenesis Mediated by Biopolymers
- 2002 - 2004 Supramolecular Asymmetric Photochirogenesis with Biopolymers as Chiral Reaction Field
- 2001 - 2004 A Novel Strategy for Active Control of DNA Recognition by External Stimulates -Peptide Ribonucleic Acids (PRNA)-
- 2001 - 2001 動的核酸認識制御機能を有する人工核酸を用いた機能性リフトマテリアルの創製
- 2001 - 2001 ガン細胞特異的に抑制機能を発現する次世代アンチセンス分子の創製
- 1999 - 2001 Regulatory system of gene expression by novel artificial anti-gene chemicals in plants
- 1999 - 2001 First Application of Biopolymers for Chiral Reaction Field of Asymmetric Photoreactions
- 2000 - 2000 外部因子によるOn-Off認識制御機能を有する新規アンチセンス分子の創製
- 1997 - 1998 ポリアミノ酸誘導体を用いた不斉反応場の構築と不斉光増感反応への応用
- 1996 - 1996 光化学的不斉反応場の構築
- 1996 - 1996 核酸を用いた人工的組織構造化による高効率光増感機能の発現
- 1996 - 1996 不斉光増感能を有するポリアミノ酸誘導体の合成およびその光不斉反応
- 1995 - 1995 核酸認識機能を有する多糖誘導体の合成およびその相互作用
- 1994 - 1994 核酸認識部位を有するポリアミノ酸誘導体の合成とその高次構造の機能に及ぼす影響
- 1993 - 1993 ヌクレオシドを側鎖に有するオリゴおよびポリアミノ酸誘導体の合成と性質に関する研究
- 1992 - 1992 インターフェロンを効果的に誘起する核酸アナログポリマーの合成と性質に関する研究
- 1990 - 1990 水溶性核酸アナログポリマーの合成とDNA,RNAとの相互作用に関する研究
Show all
Papers (277)：
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Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, et al. Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry. Nature communications. 2023. 14. 1. 7972-7972
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Yasuto Hoshikawa, Yasuyuki Kanno, Hanako Tawata, Takuya Sagae, Takafumi Ishii, Shuhei Imoto, Shinya Hagihara, Takehiko Wada, Fumi Nagatsugi, Alex Aziz, et al. Water-Dispersible Carbon Nano-Test Tubes as a Container for Concentrated DNA Molecules. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. 29. 53. e202301422
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Yasuto Hoshikawa, Yasuyuki Kanno, Hanako Tawata, Takuya Sagae, Takafumi Ishii, Shuhei Imoto, Shinya Hagihara, Takehiko Wada, Fumi Nagatsugi, Alex Aziz, et al. Water-Dispersible Carbon Nano-Test Tubes as a Container for Concentrated DNA Molecules. Chemistry - A European Journal. 2023. 29. 53. e202302594
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Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada, Asako Yamayoshi. Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters. Chembiochem : a European journal of chemical biology. 2023. 24. 15. e202200789
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Masahito Inagaki, Takehiko Wada. External Stimulation-Responsive Artificial Nucleic Acids: Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies. Handbook of Chemical Biology of Nucleic Acids (Springer Nature). 2023. 26
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MISC (606)：
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大林蓮, 柿崎知典, 荒木保幸, 和田健彦, 小田玲子. Synthesis and spectroscopic properties of chiral hexaphanes containing two anthracene molecules. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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荒木保幸, 大林蓮, 西嶋政樹, SADIKSHYA Pandey, 和田健彦. Study on the electronic excted states of hexaphane containing two acenes by transient spectroscopy. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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酒井隼人, 荒木保幸, 和田健彦, TKACHENKO Nikolai V., 羽曾部卓. Intramolecular Singlet Fission and Chiroptical Properties of Chiral Acene Dimers. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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中尾樹希, 江島穂乃香, 三瓶悠, 山本剛史, 堂野主税, 和田健彦, 山吉麻子. Development of triplex forming oligonucleotides containing novel photo-reactive nucleosides. 日本薬学会年会要旨集(Web). 2023. 143rd
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小林礼知, 上妻春草ロベルト, 石田真敏, 長谷川真士, 真崎康博, 荒木保幸, 和田健彦, 杉浦健一. Synthetic and chiroptical studies on novel fluorophores based on chiral bipyrenyl platform. 基礎有機化学討論会要旨集. 2023. 33rd (CD-ROM)
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Patents (15)：
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キメラ人工核酸製造法
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キメラ人工核酸製造法
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キメラ人工核酸による触媒的核酸医薬構築
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キメラ人工核酸による触媒的核酸医薬構築
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Chimeric molecule for suppressing function of target nucleic acid, pharmaceutical composition, cleavage method, and diagnosis kit
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Books (13)：
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高分子材料の事典
朝倉書店 2022 ISBN:9784254252729
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水中有機合成の開発動向
2022 ISBN:9784781316635
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「刺激応答型人工核酸」、進化を続ける核酸化学 : ゲノム編集、非二重らせん、核酸医薬
化学同人 2021 ISBN:9784759814019
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Recent Progress of Nucleic Acids Chemistry
2021 ISBN:9784759814019
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Intracellular information responsible artificial nucleic acids
2021 ISBN:9784781316116
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Lectures and oral presentations (188)：
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BACH1を標的とした高効率触媒的RNA切断機能付与型人工核酸(CANA)による膵臓癌治療薬開発III-in vitro解析に基づく分子設計指針の構築
(日本化学会 第104春季年会(2024) 2024)
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Supramolecular Asymmetric Photochirogenesis(SMAP) of 2-Anthracene Carboxylate and 2,6-Anthracene Dicarboxylate mediated by Serum Albumin as Chiral Reaction Nanoreactor
(Advanced Materials Research GRAND MEETING (MRM2023/IUMRS-ICA2023) 2023)
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弱い相互作用を活用した 機能発現・制御を目指した材料創製 - 光機能材料から生体機能制御を目指した核酸医薬開発まで -
(山形大学特別企画セミナー 2023)
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Novel Design Strategy of DNA-Artificial Nucleic Acid Chimera(CANA)Toward Enhancement of RNase H Mediated Target RNA Cleavage Activities : Application for COVID-19 Therapeutics IV
(50th International Symposium on Nucleic Acids Chemistry 2023 2023)
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The novel design strategy of DNA-artifcial nucleic acid chimera (CANA): Toward enhancement of RNA cleavage activities: application for COVID-19 therapeutics
(19th Annual Meeting of the Oligonucleotide Therapeutics Society(OTS2023) 2023)
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Professional career (1)：
- Doctor of Engineering (Osaka University)
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