Rchr
J-GLOBAL ID:200901096658652830
Update date: Jan. 30, 2024
Harashima Nanae
ハラシマ ナナエ | Harashima Nanae
Affiliation and department:
Research field (3):
Tumor biology
, Pathobiochemistry
, Tumor diagnostics and therapeutics
Research keywords (4):
腫瘍免疫学
, 感染免疫学
, Immunotherapy
, Tumor Immunology
Research theme for competitive and other funds (11):
- 2018 - 2019 柑橘類由来フラボノイドを用いた ヒトがん細胞に対する抗腫瘍効果の検討
- 2018 - 2019 がん特異的エネルギー代謝制御によるがん細胞死の誘導に関する研究
- 2013 - 2015 癌細胞のオートファジーと低酸素応答制御による免疫的細胞傷害抵抗性の克服
- 2011 - 2012 免疫アジュバント受容体シグナルによる癌細胞死とオートファジー
- 2010 - 2011 上皮性癌に対するToll様受容体の役割とアポトーシス誘導経路の解明
- 2009 - 2010 Fasリガンドの生理的・病理的役割の解明 課題:Toll様レセプター(TLR)刺激により誘導される前立腺癌の細胞死メカニズムの解明
- 2008 - 2009 ペプチドワクチンに基づくT細胞感受性の増強と新しい抗腫瘍免疫療法の開発
- 2008 - 2009 エピジェネティクス治療薬による腫瘍抗原発現とT細胞感受性の増強
- 2005 - 2009 Anti-viral immuno therapeutic approaches for adult T-cell leukemia
- 2003 - 2003 ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発
- Identification of tumor-associated antigens and modification for cancer therapy
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Papers (60):
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Ryosuke Tanino, Yukari Tsubata, Nanae Harashima, Mamoru Harada, Takeshi Isobe. Novel drug-resistance mechanisms of pemetrexed-treated nonsmall cell lung cancer. Oncotarget. 2018. 9. 24. 16807-16821
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Minami, Takafumi, Sugimoto, Koichi, Shimizu, Nobutaka, De Velasco, Marco, Nozawa, Masahiro, Yoshimura, Kazuhiro, Harashima, Nanae, Harada, Mamoru, Uemura, Hirotsugu. HIF-1 alpha-derived peptide capable of inducing cancer-reactive cytotoxic T lymphocytes from HLA-A24+patients with RCC. CANCER SCIENCE. 2018. 109. 331-331
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Yuichi Iida, Nanae Harashima, Takanobu Motoshima, Yoshihiro Komohara, Masatoshi Eto, Mamoru Harada. Contrasting effects of cyclophosphamide on anti-CTL-associated protein 4 blockade therapy in two mouse tumor models. CANCER SCIENCE. 2017. 108. 10. 1974-1984
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Yuichi Iida, Nanae Harashima, Takanobu Motoshima, Yoshihiro Komohara, Masatoshi Eto, Mamoru Harada. Contrasting effects of cyclophosphamide on anti-CTL-associated protein 4 blockade therapy in two mouse tumor models. Cancer science. 2017. 108. 10. 1974-1984
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Nanae Harashima, Keizo Takenaga, Miho Akimoto, Mamoru Harada. HIF-2 alpha dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression. ONCOTARGET. 2017. 8. 26. 42887-42900
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MISC (129):
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Screening by cell-based assay of natural plant extracts as candidates for novel colorectal cancer. 2022
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Inhibition of cell proliferation and metastasis in triple negative breast cancer cells by flavonoids. 2022
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Growth and migration inhibitory effect of Indole-3-carbinol on human colon and breast cancer cells. 2022
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Potential of Kalanchoe pinnata extracts in anti-colon cancer effects by inducing apoptosis. 2022
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Anticancer and antimetastatic effect through mitochondrial-mediated intrinsic pathway in flavone-treated cancer cells. 2021. 80th
more...
Patents (5):
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COMPOSITIONS AND METHODS FOR PREVENTION OR TREATMENT OF NEOPLASTIC DISEASE IN A MAMMALIAN SUBJECT.
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HLA-A11拘束性Tax抗腫瘍ペプチド
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PEPTIDE HAVING HTLV-1-SPECIFIC CTL-INDUCING ACTIVITY
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HTLV-1特異的CTL誘導活性ペプチド
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PCT/JP2004/005414
Lectures and oral presentations (3):
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Positive conversion of Tax specific CTL response in ATL patients after hematopoietic stem cell transplantation.
(AIDS Res. Hum. Retroviruses 2007)
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Major target epitopes recognized by Tax specific CTL activated in ATL patients after hematopoietic stem cell transplantation.
(AIDS Res. Hum. Retroviruses 2005)
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Reactivation of stromg HTLV-I-specific CTL response in ATL patients following Non-myeloablative hematopoietic stem cell transplantation.
(AIDS Res. Hum. Retroviruses 2003)
Education (1):
- 1997 - 2001 Kurume University Graduate School, Division of Medicine
Work history (4):
- 2017/04 - 現在 University of the Ryukyus School of Health Sciences, Faculty of Medicine
- 2007/04 - 2017/03 Shimane University Faculty of Medicine, School of Medicine
- 2002/02 - 2007/07 Tokyo Medical and Dental University
- 2005/07 - 2007/03 NIH, NHLBI
Committee career (2):
- 2011 - 現在 日本癌学会 評議員
- 2008/01 - 現在 日本癌学会 評議員
Association Membership(s) (6):
日本癌学会
, 日本バイオセラピィ学会
, 日本HTLV-1学会
, 日本分子標的治療学会
, 日本がん免疫学会
, 日本免疫学会
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