TONE Shigenobu

トネシゲノブ | TONE Shigenobu

Affiliation and department：
Job title： Professor

Research field (3)： Developmental biology , Molecular biology , Cell biology

Research keywords (4)：ベニクラゲに学ぶ若返り , 免疫寛容 , spermatogenesis , apoptosis

Research theme for competitive and other funds (27)：

2020 - 脊髄損傷患者に伴う造精機能障害に対する新規治療法の開発
2019 - リン酸基結合分子の変化によるリン吸収端構造変化とそのクロマチン可視化応用
2016 - 2019 Development of soft X-ray microscope in Water window wavelength region using Flash LPP light source
2014 - 2017 New approach to treat stroke by assessing cerebral small vessel dysfunction indicated by pulse wave velocity and biomarkers
2013 - 2016 Initinal research for tissue engineering intestine using iPS cells

2011 - 2013 Fundamental studies for development of a novel anti-tumor drug based on perchloric acid-soluble protein

2011 - 2013 Genome-wide analysis of nuclear condensation factors during apoptosis

2008 - 2010 アポトーシスにおける核凝縮の分子形態学的解析

2007 - 2008 Role of tryptophan and clarification of its action mechanism in the immunity between embryo-mother's bodies

2004 - 2005 体細胞を脱核幹細胞と融合して幹細胞化する試み

2002 - 2003 Generation of indoleamine 2,3-dioxygenase-dificient mouse

2001 - 2001 神経突起変性により誘導されるカスケードとその神経変性疾患モデルにおける解析

2000 - 2001 胚性幹細胞に体細胞の核を移植する試み-臓器移植をめざした基礎的研究-

2000 - 2000 神経突起変性により誘発される細胞内カスケードの解明

1999 - 2000 胎盤でのトリプトファン酸素添加酵素阻害は果して流産の原因となるか?

1999 - 2000 NUCLEAR PROTEIN-ANCHORING FUNCTION OF CYTOSKELETON AND ITS ANTI-APOPTOTIC EFFECTS AGAINST P53-DEPENDENT APOPTOSIS.

1996 - 1998 IFN-γで誘導されるトリプトファン分解酵素のノックアウトマウスの作製

1996 - 1998 Molecular mechanism of programmed cell death.

1996 - 1996 幼若ラット視覚野の回路発達に関する遺伝子群の検索とその役割の検討

1995 - 1996 Cell-Biological Study on Medicolegal Diagnosis of Injury

1995 - 1995 光刺激による幼若ラット視覚野の回路発達に関する遺伝子群の検索

1994 - 1995 Molecular cloning of cDNAs for transcriptional factors of indoleamine 2,3-dioxygenase induced by IFN-gamma

1994 - 1995 The roles and regulatory mechanisms of expression of proto-oncogenes in the nervous system

1993 - 1995 The development of viral vector for in vivo gene-delivery and its applications

1993 - 1993 アポトーシスの機能と分子機構

1992 - 1993 Molecular cloning of trans-acting factor cDNA for IFN-gamma-inducible indoleamine 2,3-dioxygenase

1991 - 1993 In vitro analysis of spermatogenesis in the medaka, Oryzias latipes.

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Papers (39)：

Kensuke Okugi, Natsuki Kuwahara, Natsumi Yanome, Kaito Yamada, Takuma Ito, Atsushi Takano, Shin Ohira, Atsushi Nagai, Shigenobu Toné. An in vitro system for experimentally induced cryptorchidism. Histochemistry and Cell Biology. 2022. 157. 297-307
Nutritional exchange of old and new body of just rejuvenated individual of Turritopsis sp. (Hydrozoa, Anthomedusae) from Wakayama Prefecture, Japan. 2020. 75. 140-142
Tatsufumi Murakami, Takeshi Yokoyama, Mineyuki Mizuguchi, Shigenobu Toné, Shizuka Takaku, Kazunori Sango, Hirotake Nishimura, Kazuhiko Watabe, Yoshihide Sunada. A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy. Journal of Neurochemistry. 2020. 156. 6. 957-966
. Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, et al. Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation. in vivo. 2020. 34
大塚玲桜, 藤瀬弦汰, 刀祢重信, 久保田信. 和歌山県白浜町の道路で発見されたシロマダラ. くろしお. 2018. 37. 16-16

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MISC (4)：

Andri Rezano, Kazuhiko Kuwahara, Mutsuko Yamamoto-Ibusuki, Masahiro Kitabatake, Penpak Moolthiya, Suchada Phimsen, Taiji Suda, Shigenobu Tone, Yutaka Yamamoto, Hirotaka Iwase, et al. DSS1 as potential prognostic marker for breast cancer progression and relapse-free patient survival. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2014. 34. S114-S114
Takeaki Okamoto, Shigenobu Toné, Hiroaki Kanouchi, Fumio Ohyama, Yohsuke Minatogawa. Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan analogues. International Congress Series. 2007. 1304. 352-356
F. Ohyama, S. Tone, T. Okamoto, K. Shimoda, Y. Minatogawa. Induction of indoleamine 2,3-dioxygenase in small intestine of mouse infected with parasitic helminth, Hymenolepis nana. International Congress Series. 2007. 1304. 286-289
K Machida, K Tsukiyama-Kohara, E Seike, S Tone, F Shibasaki, M Shimizu, H Takahashi, Y Hayashi, N Funata, C Taya, et al. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. JOURNAL OF BIOLOGICAL CHEMISTRY. 2001. 276. 15. 12140-12146

Lectures and oral presentations (45)：

Pathological analysis focused on inflammatory changes in bladder dysfunction following partial bladder outlet obstruction
(EAU 2020 2020)
Anti-inflammatory effect of IDO1 inhibition for acute inflammation in the prostate
(EAU 2020 2020)
前立腺内の慢性炎症性変化に対するIDO1 阻害による発症抑制作用の検証
(日本トリプトファン研究会第39 回学術集会 2019)
Role of ATG5 in apoptotic nuclear disassembly
(ASCB-EMBO 2019)
Protein analysis of infertile male testis by two-dimensional electrophoresis -Relationship between Johnsen's score and protein spots-
(ASCB EMBO 2019 meeting 2019)

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Professional career (3)：

理学士 (名古屋大学)
理学修士 (名古屋大学)
理学博士 (名古屋大学)

Committee career (5)：

2017 - 現在日本生化学会評議員
2009 - 現在日本Cell Death 学会評議員
2000 - 現在日本トリプトファン研究会評議員
1990 - 現在分子病理学研究会世話人
2009/04 - 2015/03 日本Cell Death 学会理事

Association Membership(s) (8)：

日本免疫学会 , Japan Cell Death Meeting , American Society for Cell Biology , 日本生化学会 , 日本分子生物学会 , 日本トリプトファン研究会 , International Society for Tryptophan Research , 分子病理学研究会

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