Sugase Kenji

スガセケンジ | Sugase Kenji

Affiliation and department：
Job title： Full Professor
Homepage URL (1)： https://researchmap.jp/read0006511/

Research keywords (6)： NMR , long-term memory , Biophysics , Structural Biology , Rheo-NMR , protein aggregation

Research theme for competitive and other funds (32)：

2022 - 2026 Development of analytical platform for proteins in electric field and its application
2022 - 2025 Promoting Dynamic Solution Science
2022 - 2025 Atomic-level analysis of proteins responding to dynamic solution environments using NMR
2022 - 2024 Elucidation of the mechanism of protein aggregation in flow by using Rheo-NMR and Rheo-MD
2021 - 2024 Elucidation of the mechanism of amyloid fibrillation of alpha-synuclein starting from liquid-liquid phase separation

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Papers (98)：

Tomoki Sorada, Erik Walinda, Masahiro Shirakawa, Kenji Sugase, Daichi Morimoto. An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi-domain protein. Protein Science. 2023
Yusuke Shuto, Erik Walinda, Daichi Morimoto, Kenji Sugase. Conformational Fluctuations and Induced Orientation of a Protein, Its Solvation Shell, and Bulk Water in Weak Non-Unfolding External Electric Fields. The Journal of Physical Chemistry B. 2023
Erik Walinda, Kenji Sugase, Naoki Ishii, Masahiro Shirakawa, Kazuhiro Iwai, Daichi Morimoto. Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity. Journal of Biological Chemistry. 2023. 105165-105165
Crowded environments affect structural fluctuations and abnormal aggregation of proteins. 2023. 55. 5. 42-45
Daichi Morimoto, Erik Walinda, Akihiko Yamamoto, Ulrich Scheler, Kenji Sugase. Rheo-NMR Spectroscopy for Cryogenic-Probe-Equipped NMR Instruments to Monitor Protein Aggregation. Current Protocols. 2022. 2. 12

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MISC (31)：

森本大智, ヴァリンダ・エリック, 深田はるみ, 菅瀬謙治, 蔭山俊, 星野大, 難波啓一, 小松雅明, 田中啓二, 白川昌宏. タンパク質の構造破綻とその関連疾患物性化学から臨床まで細胞内におけるユビキチン陽性タンパク質凝集体の形成機構の解明. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [1S07-3]
Nagpal Harsh, 堀哲也, Furukawa Ayako, 菅瀬謙治, 越阪部晃永, 胡桃坂仁志, 深川竜郎. 細胞周期中のCCANの構成の動的な変化(Dynamic Change of CCAN organization during the cell cycle). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2T23-13(2P0113)]
K. Kanba, A. Furukawa, K. Sugase, T. Nagata, M. Katahira. Deamination mechanism of an anti-HIV APOBEC3G coupled with sliding on single-stranded DNA as analyzed by real-time NMR monitoring method. The 41st International Symposium on Nucleic Acids Chemistry.Fukuoka. 2014
Kanba, K, Mashima, T, Okamura, H, Furukawa, A, Sugase, K, Nishimura, H, Watanabe, T, Nagata, T, Katahira, M. Real-time NMR monitoring of enzymatic reaction of anti-HIV protein, structure of anti-prion RNA aptamer and wood biomass analysis. The 5th Japan-Taiwan NMR symposium. 2014
K. Kanba, A. Furukawa, K. Sugase, R. Morishita, T. Nagata, M. Katahira. Functional mechanism of an anti-HIV protein, APOBEC3G, as revealed by real-time NMR monitoring of its enzymatic reaction. XXVIth International Conference on Magnetic Resonance in Biological Systems.Dallas. 2014

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Patents (1)：

剪断流を発生させる器具

Books (6)：

タンパク質の構造解析手法と In silicoスクリーニングへの応用事例 ~AlphaFold、In silico創薬、NMR、X線、クライオ電子顕微鏡~
技術情報協会 2023
NMRによる有機材料分析とその試料前処理、データ解釈
技術情報協会 2021 ISBN:9784861048609
Experimental Approaches of NMR Spectroscopy
Springer 2018 ISBN:9789811059667
揺らぎ・ダイナミクスと生体機能物理化学的視点から見た生体分子
化学同人 2013
Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms
Nova Science Publishers 2009

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Lectures and oral presentations (53)：

基礎講座
(第21回若手NMR研究会 2021)
Rheo-NMRによるタンパク質のアミロイド線維化過程のリアルタイム計測
(第21回日本蛋白質科学会年会 2021)
高感度Rheo-NMRによる剪断流中のタンパク質の動的構造解析
(20-1 NMR研究会 2020)
In situ Monitoring of Amyloid Fibril Formation Processes Using Rheo-NMR
(8th Asia-Pacific NMR Symposium 2019 2019)
In situ monitoring of amyloid fibril formation processes using Rheo-NMR
(RIKEN Symposium Recent Progress in Protein Conformation and Aggregation 2019)

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Professional career (1)：

Doctor (Engineering) (Yokohama National University)

Work history (10)：

2022/04 - 現在 Kyoto University Division of Applied Life Sciences, Graduate School of Agriculture Full Professor
2015/02 - 2022/03 Kyoto University Department of Molecular Engineering, Graduate School of Engineering Associate Professor
2018/04 - 2019/03 Osaka University Institute for Protein Research
2011/01 - 2015/01 Suntory Foundation for Life Sciences Bioorganic Research Institute NMR Group Leader, Senior Researcher
2009/04 - 2015/01 Kobe University Graduate School of Engineering Visiting Associate Professor

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Committee career (2)：

2023/05 - 現在日本農芸化学会関西支部参与会
2023/03 - 日本生物物理学会会誌編集委員

Awards (1)：

2017/10 - 日本学術振興会審査委員の表彰

Association Membership(s) (4)：

日本農芸化学会 , 日本生物物理学会 , The Nuclear Magnetic Resonance Society of Japan , PROTEIN SCIENCE SOCIETY OF JAPAN

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