Rchr
J-GLOBAL ID：200901097520503074   Update date: Jan. 31, 2024

Mizuguchi Mineyuki

ミズグチ ミネユキ | Mizuguchi Mineyuki
Affiliation and department：
University of Toyama Faculty of Pharmaceutical Sciences, Laboratory of Structural Biology

About University of Toyama Faculty of Pharmaceutical Sciences, Laboratory of Structural Biology


Job title： Professor
Homepage URL  (1)： http://www.toyama-mpu.ac.jp/ph/phypha2/index-j.html
Research field  (3)： Pharmaceuticals - analytical and physicochemistry ,  Biophysics ,  Structural biochemistry
Research keywords  (12)： フォールディング ,  アミロイド ,  天然変性蛋白質 ,  NMR ,  立体構造 ,  タンパク質 ,  folding ,  amyloid ,  intrinsically disordered protein ,  NMR ,  structure ,  Protein
Research theme for competitive and other funds  (28)：
  • 2022 - 2025 自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
  • 2022 - 2025 Development of ATTR amyloid clearance therapies
  • 2021 - 2024 新型アミロイドから迫る変形性膝関節症の病態解明および早期診断システムの構築
  • 2019 - 2022 How does PQBP1 suppress the induction of type I interferon expression by cGAS?
  • 2018 - 2021 Screening methods to discover ATTR amyloid disrupters
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Papers (81)：
  • Takeshi Yokoyama, Katsuhiro Kusaka, Mineyuki Mizuguchi, Yuko Nabeshima, Satoru Fujiwara. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. Journal of medicinal chemistry. 2023
  • Takuya Okada, Kaho Yamabe, Michiko Jo, Yuko Sakajiri, Tomokazu Shibata, Ryusuke Sawada, Yoshihiro Yamanishi, Daisuke Kanayama, Hisashi Mori, Mineyuki Mizuguchi, et al. Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity. Bioorganic & medicinal chemistry letters. 2023. 93. 129438-129438
  • Takeshi Yokoyama, Mineyuki Mizuguchi, Yuko Nabeshima, Yusuke Nakagawa, Takuya Okada, Naoki Toyooka, Katsuhiro Kusaka. Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin. The FEBS journal. 2023. 290. 21. 5158-5170
  • Mineyuki Mizuguchi, Takeshi Yokoyama, Takuya Okada, Yusuke Nakagawa, Kanako Fujii, Yuko Nabeshima, Naoki Toyooka. Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorganic & medicinal chemistry. 2023. 90. 117370-117370
  • Mineyuki Mizuguchi, Takeshi Yokoyama, Takahito Otani, Shiori Kuribara, Yuko Nabeshima, Takayuki Obita, Masato Hirata, Keiichi Kawano. Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity. FEBS letters. 2023. 597. 11. 1479-1488
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MISC (72)：
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Education (2)：
  • - 1999 Hokkaido University
  • - 1995 Hokkaido University School of Science
Professional career (1)：
  • 博士(理学) (北海道大学)
Work history (7)：
  • 2009/04 - 現在 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Professor
  • 2005 - University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences
  • 2004 - Toyama Medical and Pharmaceutical University
  • 2001 - Toyama Medical and Pharmaceutical University
  • 2000 - 米国The Scripps Research Institute, Research Associate
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Association Membership(s) (4)：
日本蛋白質科学会 ,  日本ペプチド学会 ,  日本核磁気共鳴学会 ,  日本生物物理学会
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