Rchr
J-GLOBAL ID：200901097626395947   Update date: Oct. 25, 2024

Hirasawa Noriyasu

ヒラサワ ノリヤス | Hirasawa Noriyasu
Affiliation and department：
Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences Division of Biochemical Pharmacology and Therapeutics Biochemical Pharmacology and Therapeutics Laboratory of Pharmacotherapy of Life-style Related Diseases

About Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences Division of Biochemical Pharmacology and Therapeutics Biochemical Pharmacology and Therapeutics Laboratory of Pharmacotherapy of Life-style Related Diseases


Job title： Professor
Research field  (2)： Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (7)： immunoregulation ,  TSLP ,  Epithelial cells ,  steroid ,  mast cells ,  histamine ,  allergy
Research theme for competitive and other funds  (28)：
  • 1993 - 現在 Signal transduction in mast cells
  • 1985 - 現在 Molecular mechanism of action of steroidal anti-inflammatory drugs
  • 1983 - 現在 Mechanism of histamine production and roles of histamine in inflammation
  • 1982 - 現在 Analysis of inflammatory reactions in experimental models in animals
  • 2021 - 2024 アレルギー罹患児のQOL向上に向けた中核的役割を担う機関としての学校のあり方
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Papers (252)：
  • Rio Yamamoto, Ryosuke Segawa, Hiyori Kato, Yuya Niino, Takeshi Sato, Masahiro Hiratsuka, Noriyasu Hirasawa. Identification of amino acids in transmembrane domains of mutated cytokine receptor-like factor 2 and interleukin-7 receptor α required for constitutive signal transduction. Biochimica et biophysica acta. Biomembranes. 2024. 1866. 7. 184359-184359
  • Shuki Yamazaki, Eiji Hishinuma, Yuma Suzuki, Akiko Ueda, Caroline Kijogi, Tomoki Nakayoshi, Akifumi Oda, Sakae Saito, Shu Tadaka, Kengo Kinoshita, et al. Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals. Biochemical Pharmacology. 2024. 116515-116515
  • Kan Fujiwara, Shota Nagasawa, Ryusei Maeyama, Ryosuke Segawa, Noriyasu Hirasawa, Takatsugu Hirokawa, Yoshiharu Iwabuchi. Biological Evaluation of Isosteric Applicability of 1,3-Substituted Cuneanes as m-Substituted Benzenes Enabled by Selective Isomerization of 1,4-Substituted Cubanes. Chemistry (Weinheim an der Bergstrasse, Germany). 2024. 30. 11. e202303548
  • Ryusei Maeyama, Ryosuke Segawa, Ryo Onodera, Masahiro Hiratsuka, Noriyasu Hirasawa. Caspases downregulate nickel and hydrogen peroxide-induced IL-8 production via modification of c-Jun N-terminal kinases. Toxicology. 2023. 153710-153710
  • Rio Yamamoto, Ryosuke Segawa, Jianwei Liu, Tomoya Isaji, Jianguo Gu, Masahiro Hiratsuka, Noriyasu Hirasawa. Effect of N-glycosylation on constitutive signal transduction by mutated cytokine receptor-like factor 2. Biochimica et biophysica acta. General subjects. 2023. 1867. 11. 130465-130465
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MISC (85)：
  • 山崎柊紀, 菱沼英史, 菱沼英史, 上田昭子, 前川正充, 前川正充, 前川正充, 佐藤裕, 公文代將希, 眞野成康, et al. Functional characterization of CYP2B6 rare variants identified in 8,380 Japanese individuals. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 菱沼英史, 菱沼英史, 小渕開, 寺内健人, 上田昭子, 田高周, 齋藤さかえ, 前川正充, 木下賢吾, 平澤典保, et al. 大規模ゲノム解析データを活用した日本人DPD活性予測パネルの構築. 日本薬学会東北支部大会講演要旨集. 2023. 62nd
  • 平塚真弘, 平塚真弘, 平塚真弘, 平塚真弘, 公文代將希, 公文代將希, GUTIERREZ Evelyn, 菱沼英史, 菱沼英史, 上田昭子, et al. バイオバンク情報を活用した40種のCYP3A4バリアントにおける機能変化解析. 日本人類遺伝学会大会プログラム・抄録集. 2021. 66th (CD-ROM)
  • 公文代將希, 菱沼英史, 菱沼英史, GUTIERREZ Evelyn, 伊藤暁生, 中西悠悦, 三枝大輔, 平澤典保, 平澤典保, 平澤典保, et al. High-activity CYP expression system in mammalian cells for functional characterization of CYP allelic variants. 日本薬物動態学会年会講演要旨集(Web). 2021. 35th
  • 菱沼英史, 菱沼英史, 成田瑶子, 公文代將希, GUTIERREZ Evelyn, 前川正充, 平澤典保, 平澤典保, 平澤典保, 平塚真弘, et al. Functional characterization of 15 allelic variants of dihydropyrimidinase identified by whole genome analysis of 4,773 Japanese individuals. 日本薬物動態学会年会講演要旨集(Web). 2021. 35th
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Books (20)：
  • Pharmaceutical Immunology
    Nankodo 2007
  • Recent Res. Devel. Immunol. 4
    Research Signpost 2002
  • Arachidonic acid cascade Q and A
    Iyaku Journal 2002
  • Recent Advances in Molecular Medicine, Allergy and Immunology
    Allied Publishers Pvt. Ltd. 2002
  • New Development of Prostaglandin Research
    Tokyo Kagaku Doujin 2001
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Lectures and oral presentations  (13)：
  • 病的血管新生の進展におけるヒスタミンの役割
    (第77回日本薬理学会年会 2004)
  • JAK3 阻害薬及びステロイド性抗炎症薬のマスト細胞活性化抑制作用機序の解析
    (第124年会日本薬学会 2004)
  • The action mechanism of dexamethasone for the inhibition of the antigen-induced interleukin-13 production in RBL-2H3 cells
    (World Allergy Organization Congress-XVIII 2003)
  • ヒスタミンと血管新生
    (第76回日本薬理学会年会 2003)
  • 増殖性炎症時の血管新生におけるヒスタミンの役割
    (第76回日本薬理学会年会 2003)
ｍore...
Education (2)：
  • - 1984 Tohoku University Graduate School, Division of Pharmaceutical Sciences 製薬化学
  • - 1982 Tohoku University Faculty of Pharmaceutical Science 薬学科
Professional career (1)：
  • 薬学博士 (Tohoku University)
Awards (3)：
  • 2006/09/09 - 日本油化学会 Oleoscience Editor's Award プロスタグランジンの血管新生制御機構
  • 1999/07 - 日本炎症学会 日本炎症学会奨励賞
  • 1995/12 - 日本薬学会東北支部 日本薬学会東北支部奨励賞
Association Membership(s) (5)：
日本炎症・再生医学会 ,  日本アレルギー学会 ,  日本薬理学会 ,  日本生化学会 ,  日本薬学会
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