Rchr
J-GLOBAL ID:200901098295821769
Update date: Sep. 25, 2024
Furukawa Tatsuhiko
フルカワ タツヒコ | Furukawa Tatsuhiko
Affiliation and department:
Job title:
professor
Research field (2):
Pathobiochemistry
, Cell biology
Research theme for competitive and other funds (40):
- 2024 - 2027 機械学習を用いた胆管癌悪性度予測モデルの構築
- 2021 - 2024 CD147/basiginを標的とした乾癬の新規治療の開発
- 2021 - 2024 Mechanisms analysis of lung cancer suppression and cell death by an autophagy inducible gene BHLHE41.
- 2019 - 2022 Approach to regulatory mechanism of copy number variation the gene amplified.
- 2016 - 2020 Evaluation of moleclar bases for suppression of gene amplification
- 2015 - 2018 Identify and database creation of gene expression related mercury in liver of the small Indian mongoose using HiCEP analysis
- 2010 - 2012 Elucidation of temozolomide resistance mechanism which is not involved in MGMT in malignant glioma
- 2010 - 2012 Exploring of regulatory substances ofTSP-1, an endogenous inhibitor of angiogenesis
- 2010 - 2012 Analysis of cooperative functions of transporters andvesicle transport system in efflux of anticancer agents
- 2009 - 2011 Chemoprevention for the microcystin-LR poisoning by natural compounds
- 2009 - 2011 Large-scale differential display system with vertebrate-common degenerate oligonucleotide primers
- 2008 - 2010 Search of natural compound activating endogenous anti-angiogenesis factor as an anti-cancer agent.
- 2005 - 2009 Molecular targeting agents that suppress invasion and metastasis of cancer cells
- 2005 - 2006 Nano-scale analysis of the drug transport mechanism of MRP1
- 2003 - 2004 Search and analysis of genes involved in the sensitivity to arsenic trioxide of human cells.
- 2000 - 2004 腫瘍増殖・浸潤・転移を抑制する新規薬剤の開発
- 2002 - 2003 Analysis of substrates transport mechanism and structural modification of MRP1
- 2002 - 2002 銅トランスポータATP7A・ATP7Bによる抗癌剤耐性の分子機構の解析
- 2001 - 2001 昆虫を指標にした内分泌攪乱物質の環境評価
- 2000 - 2001 Analysis of the mechanisms for biological activities of thymidine phosphorylase
- 1999 - 1999 チミジンホスホリラーゼのがん血管新生とアポトーシスへの関与
- 1998 - 1999 Physiological function of thymidine phosphorylase and the involvement of the enzyme in tumor growth
- 1997 - 1999 BASIC AND CLINICOPATHOLOGICAL ANALYSIS FOR MOLECULES REGULATING INVASIVE AND METASTATIC PROPERTIES OF GENITOURINARY TUMORS
- 1999 - 金属輸送体蛋白質と薬剤輸送
- 1997 - 1998 Identification and analysis of tyrosine phosphatase CD45 interacting proteins
- 1997 - 1997 チミジンホスホリラーゼ阻害剤による腫瘍増殖抑制とその基礎的研究
- 1996 - 1996 チミジンホスホリラーゼの血管新生活性の機構とその他の生理活性
- 1996 - 1996 Analysis of structure and function of GS-X pumps.
- 1995 - 1995 MRPの薬剤輸送機能とイオンチャネル活性の解折
- 1995 - 1995 MRPの機能と臨床での多剤耐性の関与およびその克服
- 1994 - 1995 Structure and function of an active efflux pump for cisplatin
- 1991 - 1991 Pー糖蛋白質の関与しない多剤耐性の分子機構の解明と克服方法の開発
- 1990 - 1991 Isolation and analysis of atypical multidrug-resistant mutants.
- 1990 - 1990 Pー糖蛋白質の構造と機能の研究
- チミジンホスホリラーゼの生物機能
- 抗癌剤耐性に関与する蛋白質についての研究
- シグナル伝達におけるチロシンホスファターゼの機能に関する研究
- Biological function of thymidine phosphorylase
- Study on Drug Resistance Cancer Cell
- Study on function of tyrosine phosphotase
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Papers (177):
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Tatsuhiko Furukawa, Kentaro Mimami, Toshiyuki Nagata, Masatasu Yamamoto, Masami Sato, Akihide Tanimoto. Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development. International journal of molecular sciences. 2023. 24. 14
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Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa, Akihide Tanimoto. MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer. BMC cancer. 2023. 23. 1. 424-424
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Shota Takumi, Kairi Hashimoto, Masaru Tomioka, Mina Sato, Weijie He, Yumiko Komatsu, Shunji Aoki, Ryuji Ikeda, Kazuhiro Shiozaki, Tatsuhiko Furukawa, et al. Acteoside from Conandron ramondioides Reduces Microcystin-LR Cytotoxicity by Inhibiting Intracellular Uptake Mediated by OATP1B3. Planta medica. 2023. 89. 6. 616-623
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Tatsuhiko Furukawa, Sho Tabata, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Akihide Tanimoto. Metabolic reprograming of cancer as a therapeutic target. Biochimica et biophysica acta. General subjects. 2022. 1867. 3. 130301-130301
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Masaya Aoki, Kazuhiro Ueda, Go Kamimura, Yoshiyuki Iwamoto, Mizuki Ikehata, Keisuke Tabata, Yuri Sakagami, Shoichiro Morizono, Takuya Tokunaga, Tadashi Umehara, et al. Clinical significance of ALKBH4 expression in non-small cell lung cancer. Translational cancer research. 2022. 11. 7. 2040-2049
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MISC (105):
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古川龍彦, 南謙太朗, 山本雅達, 河原康一. FARP1はインテグリンαvβ5に結合し,その発現上昇は進行胃がんの予後に関わる. 日本癌学会学術総会抄録集(Web). 2021. 80th
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古川龍彦, 河原康一, 南謙太朗. FARP1 boosts CDC42 activity through Integrin αvβ5 and correlates unfavorable prognoses of the patients carrying advanced gastric cancer. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2021. 25th
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古川龍彦, 南健太朗, 河原康一, 新里能成. BHLHE41 suppress lung adeno carsinoma development. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2020. 24th
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古川龍彦, 南謙太朗, 山本雅達, 河原康一, 新里能成. BHLHE41 a prognositic factor of lung adenocarcinoma, can induce authophagic cell death to lung cancer cells. 日本癌学会学術総会抄録集(Web). 2020. 79th
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古川 龍彦, 田畑 祥, 曽我 朋義. 【代謝が変える細胞と個体の運命】チミジン異化経路を介したがん細胞の低栄養抵抗性と悪性化. 生化学. 2019. 91. 1. 50-56
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Books (2):
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Core protein of receptor for ┣DBDolichos biflorus(/)-┫DB agglutinin isolated from murine teratocarcinoma共著
Glycoconjugate in Medicine, Professional Postgraduate Service 1988
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Core protein of receptor for ┣DBDolichos biflorus(/)-┫DB agglutinin isolated from murine teratocarcinoma共著
Glycoconjugate in Medicine, Professional Postgraduate Service 1988
Education (4):
- - 1989 Kagoshima University
- - 1989 Kagoshima University Graduate School, Division of Medicine
- - 1983 Kagoshima University Faculty of Medicine Department of Medicine
- - 1983 Kagoshima University Faculty of Medicine
Professional career (1):
Committee career (1):
Association Membership(s) (4):
がん分子標的治療研究会
, 日本分子生物学会
, 日本生化学会
, 日本癌学会
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