Ono Kenji

オノケンジ | Ono Kenji

Affiliation and department：
Other affiliations (1)：

Research field (1)： Neuroscience - general

Research keywords (7)： Demyelination , Glia , Extracellular vesicles , Imaging , Drug Delivery System , Microglia , Bone Marrow Transplantation

Research theme for competitive and other funds (8)：

2020 - 2023 グリア前駆細胞から放出される細胞外小胞を介した再ミエリン化の分子機構解明
2019 - 2022 Role of diabetes and inflammation on microglial cell biology and transformation
2018 - シグナルペプチド:細胞外微粒子機能の新規マーカー
2015 - 2018 Optogenetic control of differentiation into oligodendrocytes
2011 - 2012 Microglial subtypes: Identification and characterization of their roles in emotional functions

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Papers (35)：

Kenji Ono, Junpei Sato, Hiromi Suzuki, Makoto Sawada. Distribution of Signal Peptides in Microvesicles from Activated Macrophage Cells. International Journal of Molecular Sciences. 2023. 24. 15. 12131
Kenji Ono, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida, Makoto Sawada. Calmodulin as a Key Regulator of Exosomal Signal Peptides. Cells. 2022. 12. 1. 158
Kenji Ono, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida, Makoto Sawada. Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes. International Journal of Molecular Sciences. 2022. 23. 6. 3137
Yoshioka N, Tanaka M, Ochi K, Watanabe A, Ono K, Sawada M, Ogi T, Itoh M, Ito A, Shiraki Y, et al. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model. Biomed Pharmacother. 2021. 140. 111738
Ono K, Niwa M, Suzuki H, Kobayashi NB, Yoshida T, Sawada M. Secretion of signal peptides via extracellular vesicles. Biochemical and biophysical research communications. 2021. 560. 21-26

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MISC (38)：

Yudai Takatani, Kenji Ono, Hiromi Suzuki, Masato Inaba, Makoto Sawada, Naoyuki Matsuda. Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration. Laboratory Investigation. 2018. 98. 5. 629-639
Qi Wu, Kenji Ono, Hiromi Suzuki, Megumi Eguchi, Shun Yamaguchi, Makoto Sawada. Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging. Neuroscience Letters. 2018. 666. 92-97
Michiko Oya, Hiromi Suzuki, Andrea Roxanne J. Anas, Koichi Oishi, Kenji Ono, Shun Yamaguchi, Megumi Eguchi, Makoto Sawada. LC-MS/MS imaging with thermal film-based laser microdissection. Analytical and Bioanalytical Chemistry. 2018. 410. 2. 491-499
Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita. Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis. EBioMedicine. 2018. 27. 71-85-85
Kenji Ono, Hiromi Suzuki, Ryusei Yamamoto, Hideki Sahashi, Yuhei Takido, Makoto Sawada. Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line. NEUROCHEMISTRY INTERNATIONAL. 2017. 104. 49-63

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Patents (9)：

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Books (1)：

Etiology and Pathophysiology of Parkinson's Disease, Role of microglia in inflammatory process in Parkinson's disease.
InTech 2011 ISBN:9789533074627

Lectures and oral presentations (39)：

Effect of exosomal miR-155-5p from glial progenitor cells in microglial polarization at the demyelinated area
(The 46th Annual Meeting of the Japan Neuroscience Society 2023)
Detection of activated microglia by mass spectrometry imaging
(2022)
Secretion of signal peptides via exosomes
(The 95th Annual Meeting of the Japanese Biochemical Society 2022)
Analysis of exosomes released from a glial progenitor cell-line after induction of oligodendrocyte differentiation
(Neuro2022 2022)
A liquid chromatography-tandem mass spectrometry-selected reaction monitoring method for the simultaneous quantitative analysis of the translocator protein ligands PK11195 and FEPPA in the mouse brain homogenate
(2022)

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Works (12)：

名大トピックス No.229 知の未来へー若手研究者の紹介「光感受性イオンチャネルを用いた細胞機能の光制御」
2012 - 2012
Control of activation in ChR2-expressing astrocytes by blue light exposure. Neurosci Res 68: e57
2010 - 2010
Protective roles of brain-migrated immature bone marrow cells against NO-dependent neurotoxicity in a brain injury model. Neurosci Res 65: S43
2009 - 2009
Expression of cytokines and neurotrophins after acute subarachnoid hemorrhage. Stroke 39(2): 650
2008 - 2008
Enhancement of glioma formation and growth by brain-migrated immature bone marrow cells. Neurosci Res 61: S276
2008 - 2008

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Education (1)：

1998 - 2003 Nagoya City University Graduate School, Division of Pharmaceutical Sciences

Work history (9)：

2007/04/01 - 現在 Assistant Professor, Department of Brain Functions, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Assistant Professor
2007/04/01 - Assistant Professor, Department of Brain Life Science, Division of Higher Nervous Control, Research Institute of Environmental Medicine, Nagoya University
2007/04/01 - Assistant Professor, Department of Brain Functions, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University
2006/04/01 - 2007/03/31 Assistant Professor, Department of Brain Functions, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University
2006/04/01 - 2007/03/31 Assistant Professor, Department of Brain Functions, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Assistant

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Association Membership(s) (3)：

日本神経科学学会 , The Japanese Society for Neurochemistry , The Japanese Biochemical Society

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