Tatsumi Tomohide

2017 - 2020 The effect of insulin insufficiency and/or insulin resistance on pancreatic carcinogenesis and progression

2017 - 2020 Intracellular trafficking in liver disease

2017 - 2020 Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver disease

2017 - 2020 Discovery of HCC progression-related cancer genes through in vivo forward genetic screen

2017 - 2020 Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy

2016 - 2018 Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapy

2016 - 2018 Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes

2014 - 2018 The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis

2015 - 2017 Development of a liver carcinogenesis model using human hepatocytes and searching suitable anti-cancer drugs considering mutated genes.

2014 - 2017 Intracellular trafficking in the liver

2014 - 2016 Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression

2013 - 2016 The role of NK cell in the patients with hepatitis C virus infection; analysis focusing on NK cell receptor and IFN signal transducer

2013 - 2015 肥満に伴う慢性肝疾患NAFLDにおける免疫の関与とその制御に関する解析

2012 - 2015 Regulation of liver innate immunnity in human hepatocellular carcinoma

2012 - 2015 Continuous hepatocyte apoptosis induces HCC in the liver

2012 - 2014 Molecular mechanisms of acinar cell injury in acute pancreatitis

2011 - 2014 Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.

2012 - 2012 肝細胞CTGFによる肝線維化・肝発癌制御機構の解明

2009 - 2011 Bcl-2 network and regulation of cell death in non-alcoholic steatohepatitis

2009 - 2011 Immunological analysis of liver cancer stem cells and immunotherapy

2008 - 2010 Mechanisms for hepatitis B virus replication and mutagenesis : investigations using virus-expressing mouse system.

2008 - 2010 Molecular mechanism of the ectodomain shedding of the NKG2D ligand MHC class I-related chain A in hepatocellular carcinoma and its therapeutic implication

2007 - 2008 非アルコール性脂肪性肝疾患と肝硬変におけるオートファジーの解析とその意義の解明

2007 - 2008 Analysis of activation of dendritic cells by γ-PGA nano-particle and liver cancer immunotherapy

2006 - 2007 Molecular regulation of NK cell cytotoxicity fir human hepatocellular carcinoma

2005 - 2006 HBV遺伝子導入マウスでの酵素阻害剤誘発変異の解析とテーラーメイド医療への応用

2005 - 2006 CTL immuno-monitoring in chronic hepatitis C

2005 - 2006 Molecular analysis of dendritic cell based vaccines against liver cancer

2004 - 2005 Natural killer receptor-mediated regulation of dendritic cell functions in chronic hepatitis C

2000 - 2001 Therapeutic strategy for hepatocellular carcinoma by dendritic cell-based tumor vaccination

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