Rchr
J-GLOBAL ID：200901099281210828
Update date: Nov. 20, 2024
Ichijo Hidenori
イチジヨウ ヒデノリ | Ichijo Hidenori
Affiliation and department：
Homepage URL (1)：
https://saijyou.f.u-tokyo.ac.jp/index.html
Research field (2)：
Cell biology
, Pharmaceuticals - health and biochemistry
Research keywords (8)：
ALS
, Derlin-1
, ASKfamily
, Apoptosis
, Stress
, Map Kinase
, Signaling
, ASK1
Research theme for competitive and other funds (71)：
- 2020 - 2025 幹細胞、細胞死、細胞老化に着目した生体内微小環境ネットワーク解析
- 2021 - 2024 Elucidation of a novel lysosomal degradation pathway for aberrant membrane proteins at the endoplasmic reticulum
- 2017 - 2021 物理化学的ストレスに起因する老化制御シグナル伝達機構
- 2018 - 2020 Elucidation of the ASK family-regulated mechanism of cancer metastasis and search for inhibitors
- 2018 - 2020 Molecular understanding of osmotic stress sensing and response
- 2015 - 2019 International netoworking on cell competition for the next generation
- 2014 - 2019 Cell competition: a mechanism for survival of the fittest in the multi-cellular community
- 2016 - 2018 Post-translational modifications of a mitochondria-resident protein and its role in systemic regulation
- 2015 - 2018 Generation of a marmoset model of normal tension glaucoma and investigation into neuroprotection and neuroregeneration for glaucoma therapy
- 2014 - 2018 Exploring stress-responsive molecules involved in cell competition
- 2013 - 2017 Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development
- 2013 - 2015 A novel purification method for endogenous protein using ASKA technique
- 2013 - 2014 ストレスシグナルによる炎症制御と炎症慢性化機構の解明
- 2010 - 2014 生涯に亘って心身の健康を支える脳の分子基盤、環境因子、その失調の解明
- 2011 - 2012 Involvement of lipid-metabolizing enzymes in stress response
- 2008 - 2012 小胞体ストレス-ASK1経路を標的とした筋萎縮性側索硬化症治療薬の基盤開発
- 2008 - 2012 Drug development by the molecular mechanism-based analysis of stress signaling
- 2008 - 2009 RNAiスクリーニングによる浸透圧応答性キナーゼの活性制御因子群の探索
- 2007 - 2009 ストレス応答の分子機構〜結合タンパク質群によるASKファミリー活性制御の構造的分子基盤〜
- 2005 - 2009 Regulation of cell proliferation and cell death by stress signaling in cancer
- 2008 - 2008 口腔疾患に関わるストレスシグナル解明への遺伝学的アプローチ
- 2006 - 2007 Regulatory mechanisms of mucosal immunity by the ASK family signals
- 2002 - 2007 ストレスの受容・認識とシグナル変換の分子機構
- 2005 - 2006 ASK1キナーゼによる病原体感染ストレス応答シグナルの活性化と生体防御機構
- 2005 - 2006 Analysis of the innate immune system through the ASK1-p38 MAP kinase pathway in mucosal immunity
- 2005 - 2006 異常タンパク質蓄積による細胞死分子機構の解明とコンフォメーショナル病への応用
- 2002 - 2006 Elucidation of the activation mechanisms and functions of ASK1
- 2005 - 2005 異常蛋白質蓄積によるASK1シグナルを介した神経変性細胞死の分子病態の解明
- 2004 - 2005 p38MAPキナーゼ-ASK1系を経由する自然免疫シグナル伝達機構の解明
- 2003 - 2005 Regulation of skin innate immunity by epidermal differentiation
- 2001 - 2005 Comprehension and application of biological information system based on the analysis of molecular mechanisms of stress response
- 2004 - 2004 ASK1-p38MAPキナーゼ系を介する免疫監視シグナル伝達機構の解明
- 2003 - 2004 MAPKKKのインタラクトームによるストレス受容・認識の分子機構の網羅的解明
- 2003 - 2004 Mechanism investigation of signal transduction on scar tissue formation of palatal mucosa
- 2003 - 2004 Proteome analysis of phosphorylation signaling pathways involved in maxillofacial development
- 2003 - 2004 小胞体ストレス誘導性アポトーシスの分子機構と疾患
- 1999 - 2004 シグナル伝達機構に基づく細胞の分化と死の制御機構
- 2002 - 2002 小胞体内異常タンパク質蓄積にともなう細胞死のメカニズムと神経変性疾患
- 2001 - 2002 Identification of molecular mechanisms of ER stress-induced apoptosis
- 2001 - 2002 Identification of molecular mechanisms of neuronal cell death through ASK1
- 2001 - 2002 ASK1分子の活性制御機構に基づくアポトーシス制御法の開発と応用
- 2001 - 2002 Development and application of stress-signal transduction system as an assessment ofbiomaterials
- 2001 - 2002 Role of the NO-activated MAP kinase pathways in carcinogenesis
- 2000 - 2001 Analysis of the Roles for Stress-activated MAP kinases in Oral Muco-epithelium
- 1999 - 2000 Keratinocyte apoptosis by Daxx-ASK1-JNK-p38 pathway
- 1999 - 2000 Development of Biological Safty Testing Using Endocrine Disruping Effects
- 1999 - 2000 内分泌攪乱作用を中心とした歯科用材料の生物学的安全性評価に関する研究
- 1999 - 1999 神経組織形成機構におけるASK1-MAPキナーゼ系の役割
- 1999 - 1999 ASK1-MAPキナーゼ系を介するアポトーシスシグナル伝達機構の解明
- 1999 - 1999 がんの発生、発達に関する情報伝達の解析
- 1998 - 1999 Analysis of ASK1 and ASK2 as stress signaling intermediates.
- 1998 - 1998 形態形成におけるASKファミリー分子の役割
- 1998 - 1998 アポトーシス刺激伝達系におけるASK1ならびにASK2の解析
- 1997 - 1998 Mechanisms of programd cell death and morphogenesis in cranio-facial development.
- 1997 - 1998 Signainrg Mechanism and Biological Action of the Members of the Transforming Growh Factor beta Superfamily
- 1997 - 1997 骨形成因子(BMP)によって誘導される新規遺伝子の形態形成における機能の解析
- 1997 - 1997 アポトーシスシグナル伝達機構としてのMAPキナーゼカスケードの解析
- 1995 - 1997 Mechanism of Action and Clinical Application of the Type beta Transforming Growth Factor
- 1996 - 1996 Bioactivity and Clinical Application of New Members in the TGF-beta Superfamily
- 1996 - 1996 STUDY FOR INTRACELLULAR SIGNAL TRANSDUCTION MECHANISM OF TGF-beta SUPERFAMILY.
- 1996 - 1996 癌細胞の形質特異性とTGF-βファミリー因子群のシグナル伝達異常
- 1995 - 1995 TGF-βレセプターによるシグナル伝達機構の研究
- 1995 - 1995 癌細胞の自律性増殖におけるTGF-βのシグナル伝達機構の役割
- 1995 - 1995 血球細胞でのTGF-βとアクチビンレセプターの発現と造血調節機構の研究
- 1995 - 1995 形態形成におけるアクチビンおよび骨形成因子レセプターの役割
- 1994 - 1995 Studies on the signal transduction of bone morphogenetic protein (BMP)
- 1994 - 1994 口腔扁平上皮癌細胞におけるTGF-B受容体の癌特異的変異の解析
- 1994 - 1994 IGF-B スーパーファミリー受容体の構造および機能解析
- 1994 - 1994 口腔扁平上皮癌の発生機構の分子病理学的研究
- 1993 - 1993 TGF-beta受容体の構造および機能解析
- Signal Transduction of ASK-MAP kinase system.
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Papers (257)：
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Shota Yamauchi, Yuki Sugiura, Junji Yamaguchi, Xiangyu Zhou, Satoshi Takenaka, Takeru Odawara, Shunsuke Fukaya, Takao Fujisawa, Isao Naguro, Yasuo Uchiyama, et al. Mitochondrial fatty acid oxidation drives senescence. Science advances. 2024. 10. 43. eado5887
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Hiroki Ryuno, Yusuke Hanafusa, Takao Fujisawa, Motoyuki Ogawa, Hiroki Adachi, Isao Naguro, Hidenori Ichijo. HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding. Communications biology. 2024. 7. 1. 1290-1290
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Riko Tabuchi, Yurika Momozawa, Yuki Hayashi, Hisashi Noma, Hidenori Ichijo, Takao Fujisawa. SoDCoD: a comprehensive database of Cu/Zn superoxide dismutase conformational diversity caused by ALS-linked gene mutations and other perturbations. Database. 2024. 2024
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Takeru Odawara, Shota Yamauchi, Hidenori Ichijo. Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging. Communications Biology. 2024. 7. 1
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Yuki Hayashi, Hidenori Ichijo. Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP. Autophagy. 2024
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MISC (129)：
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小川基行, 名黒功, 一條秀憲. Cell competition induced by Scribble deficiency in cultured mammalian cells. 医学のあゆみ. 2020. 274. 5
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Lorenzo Galluzzi, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, et al. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. 2018. 25. 3. 486-541
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松沢厚, 一條秀憲. ASK1キナーゼによるレドックスシグナル制御-多彩な翻訳後修飾を介したシASK1キナーゼによるレドックスシグナル制御-多彩な翻訳後修飾を介したシグナル制御とその破綻による疾患. 実験医学 増刊「レドックス疾患学」. 2018. 36. 5. 692-698
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Hidenori Ichijo. Foreword. Advances in Biological Regulation. 2017. 66. 1
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今村 聖路, 吉種 光, 服部 一輝, 名黒 功, 一條 秀憲, 深田 吉孝. プロテインキナーゼ:生理機能へのアプローチとリン酸化解析の統合 ストレスシグナルを概日時計に入力するストレス応答性キナーゼASK. 生命科学系学会合同年次大会. 2017. 2017年度. [2PW15-2(3P
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Education (2)：
- 1986 - 1990 Tokyo Medical and Dental University Graduate School of Dental Sciences Doctoral course
- 1979 - 1985 Tokyo Medical and Dental University Faculty of Dentistry
Professional career (1)：
- Ph.D. (Tokyo Medical and Dental University)
Work history (8)：
- 2024/04 - 現在 Cell Signaling and Stress Responses Laboratory Advanced Research Institute Tokyo Medical and Dental University Distinguished University Professor
- 2002/09 - 2024/03 The University of Tokyo Graduate School of Farmaceutical Sciences Professor
- 2000/04 - 2003/03 Tokyo Medica and Dentall University Graduate School of Medical and Dental Sciences, Professor
- 1998/02 - 2000/03 Tokyo Medica and Dentall University Faculty of Dentistry Professor
- 1997/05 - 1998/01 The Cancer Institute of Jpanese Foundation for Cancer Research Biochemistry Senior Researcher
- 1995/04 - 1997/04 The Cancer Institute of Jpanese Foundation for Cancer Research Biochemistry Researcher
- 1992/04 - 1995/03 Tokyo Medica and Dentall University
- 1990/04 - 1993/03 Ludwig Cancer Research Uppsala Branch Researcher
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Committee career (9)：
Awards (11)：
- 2021 - 日本学士院賞
- 2020 - 武田科学振興財団 武田医学賞
- 2019/11 - 紫綬褒章
- 2017 - 安田記念医学財団 安田医学賞
- 2016 - The Uehara Memorial Foundtion Uehara Prize
- 2015 - Daiichi Sankyo Foundation of Life Science Takamine Memorial Daiichi Sankyo Prize
- 2013 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Academic Award of the Mochida Memorial foundation
- 2008 - Japanese Cancer Association JCA-Mauvernay Award of the Japanese Cancer Association
- 2001 - Japanese Association for Oral Biology LION Award for the Japanese Association for Oral Biology
- 1998 - Japanese Cancer Association Incitement Award of the Japanese Cancer Association
- 1997 - Japanese Association for Oral Biology Academic award for the Japanese Association for Oral Biology
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Association Membership(s) (12)：
日本学術会議
, 日本Cell Death学会
, 日本がん分子標的治療学会
, 日本臨床ストレス応答学会
, 日本薬理学会
, 日本口腔科学会
, 日本薬学会
, 日本分子生物学会
, 日本生化学会
, 歯科基礎医学会
, 日本癌学会
, 口腔病学会
