Taka Hikari

タカヒカリ | Taka Hikari

Affiliation and department：
Job title： Researcher
Homepage URL (1)： http://www.med.juntendo.ac.jp/kenkyu/53index.html

Research field (1)： Molecular biology

Research keywords (6)： Proteome解析 , 生理活性物質の超微量分析 , ペプチド及びプロテインの構造に関する研究 , Proteome Analysis , Microanalysis for physiological substance. , Structural Analysis of Peptide and proteins.

Research theme for competitive and other funds (10)：

2019 - 2024 体質と環境のミスマッチから生じる非感染性慢性疾患(NCDs)発症リスクの機構解明
2018 - 2020 メタボロミクスが究明する低出生体重児疾患発症リスク因子解明による先制医療の実現
2017 - 2019 結節性硬化症遺伝子変異が惹起する代謝変動とエピゲノム制御異常の解明
2016 - 2018 体質と環境のミスマッチが生じる糖尿病発症の機構解明による先制医療の実現
2013 - 2015 膀胱がんにおける尿中腫瘍マーカーの探索

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Papers (33)：

Kenji Yamatoya, Masaru Kurosawa, Michiko Hirose, Yoshiki Miura, Hikari Taka, Tomoyuki Nakano, Akiko Hasegawa, Kyosuke Kagami, Hiroshi Yoshitake, Kaoru Goto, et al. OVGP1 is an oviductal fluid factor essential particularly for early embryonic development in golden hamsters. 2022
Shinji Saiki, Yukiko Sasazawa, Motoki Fujimaki, Koji Kamagata, Naoko Kaga, Hikari Taka, Yuanzhe Li, Sanae Souma, Taku Hatano, Yoko Imamichi, et al. A metabolic profile of polyamines in parkinson disease: A promising biomarker. Annals of neurology. 2019. 86. 2. 251-263
Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N, Kikkawa M, Arai H, et al. Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine. Sci Rep. 2018. 8. 1. 16837
Shoji H, Taka H, Kaga N, Ikeda N, Hisata K, Miura Y, Shimizu T. Choline-related metabolites influenced by feeding patterns in preterm and term infants. J Matern Fetal Neonatal Med. 2018. 1-6
Motoki Fujimaki, Shinji Saiki, Yuanzhe Li, Naoko Kaga, Hikari Taka, Taku Hatano, Kei-Ichi Ishikawa, Yutaka Oji, Akio Mori, Ayami Okuzumi, et al. Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. Neurology. 2018. 90. 5. e404-e411-e411

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MISC (49)：

中鏡暁子, 斉木臣二, 藤巻基紀, 笹澤有紀子, 波田野琢, 石川景一, 王子悠, 森聡生, 奥住文美, 上野真一, et al. Levodopa代謝物に着目したParkinson病患者の病態評価に有用な血漿バイオマーカーの探索. パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2019. 13回. 101-101
高ひかり, 加賀直子, 上野隆, 三浦芳樹, 根本崇宏. 低出生体重仔への高脂肪食負荷による非感染性慢性疾患(NCDs)発症リスクへの影響. 日本生化学会大会(Web). 2018. 91st. ROMBUNNO.3P-374 (WEB ONLY)
東海林宏道, 北村知宏, 清水俊明, 三浦芳樹, 高ひかり, 加賀直子. 生後1ヵ月児における栄養法別の尿中コリン代謝物に関する検討. 日本小児栄養消化器肝臓学会雑誌. 2016. 30. Suppl. 82-82
K. Sekihara, S. Yamamoto, M. Kikkawa, H. Taka, N. Kaga, H. Matsushita, H. Hayashi, M. Tanaka, T. Miida, M. Andreeff, et al. The mTOR kinase inhibitor AZD-2014 enhances the antitumor effects of XPO1 antagonist KPT-185 in mantle cell lymphoma. ANNALS OF ONCOLOGY. 2015. 26. 39-39
Yoko Tabe, Shinichi Yamamoto, Mika Kikkawa, Hikari Taka, Kaoru Mogushi, Hiromichi Mastushita, Takashi Miida, Michael Andreeff, Paul A. Spagnuolo, Marina Konopleva. Novel FAO Inhibitor Avocatin B Induces Apoptosis of Acute Monocytic Leukemia Cells in Adipocyte Co-Culture System Via ER Stress and ATF4 Activation. BLOOD. 2015. 126. 23

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Books (2)：

分子腎臓病学実験操作法
文光堂 2003
CHARACTERIZATION OF A SYNTHETIC PEPTIDE AND BY-PRODUCTS USING A PEPTIDE SEQUENCER, MASS SPECTROMETER, AND CAPILLARY ELECTROPHORESIS
Spectrometry San-ei Publishing Co, 1992

Works (2)：

ONOOによるヒトCu, Zn-SOD蛋白質におけるTrp修飾の質量分析計による解析
2000 -
Structure analysis for modified Trp of human Cu, ZN-SOD induced with ONOO using a mass spectrometer
2000 -

Professional career (2)：

Doctor of medicine (Juntendo University)
Master (Hokuriku University)

Association Membership(s) (2)：

日本質量分析学会 , 日本生化学会

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