Higashi Hideaki

ヒガシヒデアキ | Higashi Hideaki

Affiliation and department：
Job title： Professor

Research field (1)： Molecular biology

Research keywords (5)： Anthrax , 細菌 , ヘリコバクターピロリ , 感染症 , 癌

Research theme for competitive and other funds (23)：

2018 - 2023 Development of anthrax vaccine based on structural information of toxins
2017 - 2020 Analyzing a relationship between a diffusion of pathogenic microorganisms in river water and occurrences of infectious disease in Zambia
2016 - 2019 An acellular bioresorbable ultra-purified alginate gel promotes intervertebral disc repair
2015 - 2019 Infection control index for preventing Bacillus cereus nosocomial outbreak
2012 - 2015 Mechanism of carcinogenesis by bacterial pathogenic factor

2011 - 2014 Structure-based analysis of pathogenic activity of Helicobacter pylori CagA

2009 - 2010 ヘリコバクターピロリCagAの分子立体構造と病原生物活性の相関

2008 - 2010 Structure-based analysis of biological activity of Helicobacter pylori CagA

2008 - 2009 ヘリコバクターピロリ病原因子CagAの分子構造と機能解析

2007 - 2008 ヘリコバクターピロリCagAの分子構造と病原生物活性の関連

2006 - 2007 ヘリコバクターピロリ病原因子CagAの分子構造解析

2005 - 2006 Study of H. pylori CagA-mediated gastric pathogenesis

2004 - 2005 Disturbance of cell signaling by H. pylori CagA

2003 - 2004 Disturbance of intracellular SHP-2 activity and cell growth regulation by Helicobacter pylori CagA

2003 - 2004 ヘリコバクター・ピロリ菌感染を起点とする胃癌発症機構の解析

2003 - 2003 腫瘍由来変異型pRBによるサイクリンD1の発現誘導と細胞癌化における意義

2003 - 2003 H.pylori CagA蛋白による細胞内シグナルネットワークの撹乱

2002 - 2002 胃がん発癌蛋白としてのヘリコバクター・ピロリ菌CagA蛋白の役割

2002 - 2002 ヘリコバクター・ピロリ菌病原性因子としてのCagA蛋白の役割とその作用機構

2001 - 2002 Helicobacter pylori CagA蛋白質の宿主細胞における機能解析

2001 - 2001 細胞形質を指標とした疾患関連遺伝子単離・同定法の開発

2000 - 2001 細胞形質を指標とした疾患関連遺伝子単離・同定法の開発

Regulation of cell cycle

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Papers (100)：

Chikwanda Chileshe, Misheck Shawa, Nelson Phiri, Joseph Ndebe, Cynthia Sipho Khumalo, Chie Nakajima, Masahiro Kajihara, Hideaki Higashi, Hirofumi Sawa, Yasuhiko Suzuki, et al. Detection of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteriaceae from Diseased Broiler Chickens in Lusaka District, Zambia. Antibiotics (Basel, Switzerland). 2024. 13. 3
Misheck Shawa, Atmika Paudel, Herman Chambaro, Harvey Kamboyi, Ruth Nakazwe, Luke Alutuli, Tuvshinzaya Zorigt, Taona Sinyawa, Mulemba Samutela, Joseph Chizimu, et al. Trends, patterns and relationship of antimicrobial use and resistance in bacterial isolates tested between 2015-2020 in a national referral hospital of Zambia. PloS one. 2024. 19. 4. e0302053
Saicheng Zhang, Yuki Funahashi, Satoho Tanaka, Torahiko Okubo, Jeewan Thapa, Shinji Nakamura, Hideaki Higashi, Hiroyuki Yamaguchi. Chlamydia trachomatis relies on the scavenger role of aryl hydrocarbon receptor with detyrosinated tubulin for its intracellular growth, but this is impaired by excess indole. Microbes and Infection. 2023. 25. 5. 105097-105097
Hirofumi Uchiyama, Daisuke Muramatsu, Hideaki Higashi, Hiroshi Kida, Atsushi Iwai. Effects of chondroitin sulfate oligosaccharides on osteoclast differentiation of RAW264 cells, and myotube differentiation of C2C12 cells. PloS one. 2023. 18. 4. e0284343
Daisuke Muramatsu, Hirofumi Uchiyama, Hideaki Higashi, Hiroshi Kida, Atsushi Iwai. Effects of heat degradation of betanin in red beetroot (Beta vulgaris L.) on biological activity and antioxidant capacity. PloS one. 2023. 18. 5. e0286255

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MISC (45)：

小川寛人, 小川寛人, 小川寛人, 梶原将大, 直亨則, 丸山隼輝, 上野恵介, 石井秋宏, 石井秋宏, 藤倉大輔, et al. ザンビア共和国に飛来するストローオオコウモリ(Eidolon helvum)から分離されたアデノウイルスの性状解析と分子疫学的解析. 日本獣医学会学術集会講演要旨集. 2016. 159th. 376
M Hatakeyama, K Yokoyama, H Higashi, S Ishikawa, T Azuma, T Hirayama, H Aburatani. Reciprocal regulation of NFAT transcription factors by the two major Helicobacter pylori virulence factors, CagA and VacA. HELICOBACTER. 2005. 10. 5. 471-471
堤良平, 東秀明, 畠山昌則. 【H.pylori感染の基礎と臨床】 H.pyloriの胃粘膜障害機序宿主側から. Surgery Frontier. 2004. 11. 2. 122-125
東秀明, 畠山昌則. ヘリコバクターピロリCagAによるSHP-2の脱制御 (特集解明が進むプロテインホスファターゼ--その新機能から疾患への関わりまで) -- (チロシンホスファターゼ). 細胞工学. 2004. 23. 5. 551-555
M Higuchi, R Tsutsumi, H Higashi, M Hatakeyama. Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. CANCER SCIENCE. 2004. 95. 5. 442-447

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Books (1)：

Recent Advances in Gastrointestinal Carcinogenesis
Transworld Research Network 2006

Professional career (1)：

(BLANK)

Awards (3)：

2003 - 日本癌学会奨励賞
2002 - 消化管細胞機能研究会特別賞
2002 - 日本ヘリコバクター学会上原<I>H. pylori</I> 最優秀賞

Association Membership(s) (3)：

JAPANESE SOCIETY FOR BACTERIOLOGY , 日本ヘリコバクター学会 , 日本癌学会

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