Rchr

J-GLOBAL ID：200901099611790249 Update date: Oct. 28, 2024

Araki Eiichi

アラキエイイチ | Araki Eiichi

Affiliation and department：
Job title：教授
Homepage URL (1)： http://www2.kuh.kumamoto-u.ac.jp/met/

Research field (1)： Metabolism and endocrinology

Research theme for competitive and other funds (49)：

2021 - 2024 インスリン受容体β鎖と転写因子FoxK1/2の核内共移行機序と標的遺伝子の解析
2021 - 2024 抗糖尿病効果を発揮する熱ストレス応答経路の多臓器間クロストーク解明
2019 - 2022 Examination of the role of CRTC, a CREB coactivator, on arteriosclerosis
2018 - 2021 Organ- and intermolecular interactions of heat stress response pathway activation that exert anti-diabetic effects
2017 - 2021 Mechanism of mineralocorticoid receptor-mediated regulation of GLP-1 secretion and chronic inflammation in pancreatic islet cells

2017 - 2020 Investigation of effects for metabolic changes in kidney and diabetic nephropathy by SGLT2 inhibitor

2017 - 2020 Elucidation of the effects of anti-diabetes and anti-complications by activation of heat shock response pathway and translation for clinical application

2016 - 2019 Analysis and identification of microRNA that regulates insulin signal pathway

2015 - 2018 Signaling and Browning in White Adipose Tissues by the Receptors for Short-Chain Fatty Acids

2015 - 2018 Molecular mechanisms of anti-inflammatory and anti- diabetic effects in the activation of heat shock response

2015 - 2018 Involvement of mtROS and Warburg effect in diabetic complications progression mechanism by hypoglycemia

2015 - 2018 The role of Cdkal1-mediated tRNA modification in peripheral neuropathy

2014 - 2017 Evaluation of the association between intracerebral insulin action and cognitive impairment in animal models of Alzheimer disease

2014 - 2017 Role of mitochondrial ROS generation in the development of diabetic complications

2013 - 2016 Development of miniaturized glucose monitoring system by combining a needle-type glucose sensor with intravenous microdialysis sampling method for artificial endocrine pancreas

2012 - 2015 The mechanisms of anti-inflammatory effects by the activation of heat shock response

2011 - 2014 Molecular analysis of cell stress regulation by molecular chaperon and application for diabetes treatment

2011 - 2013 Effect of overexpression of COX-2 on the progression of atherosclerosis via activation of PPARs in macrophages

2010 - 2012 Development of wearable artificial endocrine pancreas with needle-typeglucose sensor and closed-loop subcutaneous insulin infusionalgorithm

2009 - 2011 Identification of novel molecules associated with insulin action or insulin secretion induced by mild electric current and hyperthermia therapy

2009 - 2011 Effect of cPLA_2 inhibition on the prevention of diabetic macrovascular complication

2009 - 2010 ヒストン脱アセチル化酵素による糖代謝調節機序の解明

2008 - 2010 Development of novel treatment for type 2 diabetes by regulating cellular stresses targeted to molecular chaperone.

2007 - 2008 Role of reactive oxygen species in white and brown adipose tissuesin pathogenesis of insulin resistance

2007 - 2008 The inhibition of pancreatic b-cell deficiency and regenerationof β -cells by incretin signals

2006 - 2007 Development of non-blood sampling blood glucose monitoring system based on intravascular microdialysis sampling method

2005 - 2006 Proteomics analysis for the novel liver specific transcription factors and clarification of their control signals

2005 - 2006 Development of near-infrared measuring system for blood glucose and haemoglobin A1c

2004 - 2005 DEVELOPMENT OF A HIGHLY RESPONSIVE NEEDLE-TYPE GLUCOSE SENSOR USING POLYIMIDE FOR A WEARABLE ARTIFICIAL ENDOCRINE PANCREAS

2004 - 2005 Analysis of the mechanisms of pancreatic β-cells destruction by intra-cellular oxidative stress and endoplasmic reticulum stress, and its application for the diabetes treatment.

2004 - 2005 脂肪細胞におけるインスリン作用伝達分子の発現調節と生体機能制御における意義

2003 - 2005 コンディショナルノックアウトによる膵β細胞カルモジュリンキナーゼIIの機能解析

2003 - 2005 生理的血糖制御を目指した門脈内インスリン注入アルゴリズムの開発

2004 - 2004 罹患同胞対を利用した2型糖尿病感受性遺伝子の解明に関する研究

2002 - 2004 インスリン腹腔内注入アルゴリズムの開発?完全植え込み型投与システムへの応用

2002 - 2004 新規糖尿病発症機構:小胞体ストレス応答による膵β細胞アポトーシス機序の解析

2001 - 2002 The role of mitochondria-derived reactive oxygen species in the pathogenesis of diabetic complications

2000 - 2001 Molecular mechanisms of insulin resistance in obesity-induced IRS-1 heterozygous knockout mice.

2000 - 2000 膵β機能再構築インスリン分泌培養細胞を応用したバイオハイブリット型人工膵島の開発

1999 - 2000 Analysis of mechanism in insufficiency of insulin secretion and transcription factors by glucotoxicity.

1999 - 2000 DEVELOPMENT OF NON-INVASIVE BLOOD GLUCOSE MEASUREMENT BY FOURIER TRANSFORM INFRARED SPECTROSOPIC ANALYSIS THROUGH THE MUCOUS MEMBRANE OF THE LIP USING CHALCOGENIDE OPTICAL FIBER SYSTEM

1998 - 2000 Study of mechanism of potentiation of insulin sensitivity during exercise-bradykinin induced glucose uptake in muscle

1998 - 1999 Molecular and developmental biological analysis of impact of genetic and environmental factors on the development of insulin resistance

1997 - 1998 Biological clearance system for advanced glycation end products (AGE) -Insulin signal regulates endocytic uptake of AGE-proteins

1996 - 1997 Analysis of the Mechanisms of Cell and Tissue Specific Expression of the Insulin Receptor Substrate, IRS-1 Gene.

1996 - 1997 Analysis of Mechanizm of Glucose Responsive Human Insulin Gene Expression.

1994 - 1995 Mechanism of insulin action on pancreatic Alpha cells-gene analysis of insulin receptor-

1994 - 1995 Analysis of Insulin Receptor Substrate-1 (IRS-1) Gene Mutations in Non-Insulin Dependent Diabetes Mellitus.

1994 - 1995 IMPLICATION OF INSULIN GENE-THERAPY SYSTEM IN DIABETES TREATMENT : CONSTRUCTION OF BIO-ARITFICIAL PANCREATIC B CELL

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Papers (265)：

Shizuya Yamashita, Eiichi Araki, Hidenori Arai, Koutaro Yokote, Ryohei Tanigawa, Ayumi Saito, Hideki Suganami, Sara Minamikawa, Shun Ishibashi. Clinical Pharmacology of Pemafibrate Extended-release Formulation in Patients with Hypertriglyceridemia-A Phase 2, Multicenter, Active-controlled, Randomized, Single-blind, Crossover study. Journal of atherosclerosis and thrombosis. 2024
Tsugumasa Toma, Nobukazu Miyakawa, Yuiichi Arakaki, Takuro Watanabe, Ryosei Nakahara, Taha F S Ali, Tanima Biswas, Mikio Todaka, Tatsuya Kondo, Mikako Fujita, et al. An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models. Diabetologia. 2024
Shun Ishibashi, Hidenori Arai, Koutaro Yokote, Eiichi Araki, Mao Watanabe, Michiko Nakanishi, Yuichi Makinose, Hideki Suganami, Yuji Kurihara, Shizuya Yamashita. Pharmacokinetics and Safety of Pemafibrate in Patients with both Dyslipidemia and Severe Renal Impairment: A Phase 4 Study. Journal of atherosclerosis and thrombosis. 2024
田尻絵里, 外村彩夏, 小野薫, 井形元維, 西田健朗, 荒木栄一, 下田誠也. 日本人若年成人における耐糖能障害の特徴と耐糖能に影響を及ぼす生活習慣の検討. 日本病態栄養学会誌. 2024. 27. 2. 201-207
羽根田昌樹, 村田雄介, 近藤龍也, 柊中智恵子, 安部東子, 井形元維, 荒木栄一, 窪田直人. 性腺機能低下症に眼コロボーマ、難聴、無嗅症を合併し、カルマン症候群を疑って遺伝子検査を行った一例. 日本内分泌学会雑誌. 2024. 100. 1. 332-332

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MISC (1,339)：

近藤龍也, 宮川展和, 北野さやか, 渡邊拓郎, 吉積臨太郎, MARY Ann Suico, 阪口雅司, 井形元維, 松村剛, 甲斐広文, et al. 熱ストレス応答経路の多臓器間クロストーク. 糖尿病(Web). 2023. 66. 5
阪口雅司, 岡川章太, 大久保侑馬, 大塚由理, 福田一起, 井形元維, 近藤龍也, 荒木栄一. Targeting Adipose tissue Insulin Resistance to treat Metabolic Syndrome. 糖尿病(Web). 2023. 66. Suppl
瀬ノ口隆文, 瀬ノ口隆文, 井形元維, 宮村信博, 阪口雅司, 三隅洋平, 才田謙, 松本直通, 植田光晴, 荒木栄一. SLC5A2新規変異による腎性糖尿とMODY2を合併した1家系. 糖尿病(Web). 2023. 66. Suppl
吉積臨太郎, 近藤龍也, 渡邊拓郎, 宮川展和, 北野さやか, 小野薫, 花谷聡子, 後藤理英子, 阪口雅司, 吉永佳代, et al. 温熱微弱電流療法によるマクロファージ極性変化を伴った抗動脈硬化作用の検討. 糖尿病(Web). 2023. 66. Suppl
羽根田昌樹, 福田一起, 福田一起, 宮川克俊, 清原由紀夫, 古賀荒太郎, 水流添覚, 古川昇, 津山友徳, 津山友徳, et al. 日本人の加齢による2型糖尿病発症機序の解明(合志スタディ). 糖尿病(Web). 2023. 66. Suppl

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Patents (1)：

炎症及び過剰免疫を抑制する装置、並びに炎症及び過剰免疫を抑制するための剤及び方法

Books (139)：

2. 成因と治療 3)マクロファージ
最新医学社 2017
学会印象記 EASD 2016(12-16 September in Munich, Germany)
メディカルレビュー社 2017
座談会「Islet Equality」創刊5年を振り返る-膵島研究の変遷-
メディカルレビュー社 2017
熊本宣言2013とその後について
Fujifilm 2017
微弱電流と温熱刺激による新規糖尿病治療
羊土社 2017

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Lectures and oral presentations (365)：

(座長)受賞講演
(第57回日本糖尿病学会九州地方会 2019)
(座長)学会賞受賞講演
(第69回日本体質医学会 2019)
(座長)ランチョンセミナー
(第69回日本体質医学会 2019)
セミナー発言
(第36回糖尿病UpDate賢島セミナー 2019)
(座長)教育講演
(第27回西日本肥満研究会 2019)

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Works (45)：

臨床・基礎・社会医学一体型先端教育の実践
2008 - 2011
糖尿病の新規血清マーカーの発見と臨床応用の確立
2007 - 2008
第23回熊本医学生物科学シンポジウム
2007 - 2008
小児・思春期(若年)2型糖尿病の合併症発症率の経年的全国調査
2007 - 2008
インクレチンシグナルによる膵β細胞障害阻止と膵β細胞再生の試み
2007 - 2008

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Education (4)：

- 1990 Kumamoto University
- 1990 Kumamoto University Graduate School, Division of Medicine
- 1983 Kumamoto University School of Medicine
- 1983 Kumamoto University Faculty of Medicine

Professional career (1)：

Doctor of Medicine (Kumamoto University)

Work history (12)：

2010 - Kumamoto University Faculty of Life Sciences
2010 - Professor,Faculty of Life Sciences(Clinical medicine group),Kumamoto University
2003 - 2009 教授
2003 - 2009 Professor,
2000 - 2003 教授

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Committee career (20)：

2012 - 日本臨床分子医学会評議員
2012 - 日本糖尿病学会糖尿病治療ガイド編集委員会委員長
2012 - 日本糖尿病学会糖尿病専門医試験委員会委員長
2012 - 日本糖尿病学会常務理事
2012 - 日本体質医学会常任理事

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Awards (11)：

2022 - 日本病態栄養学会アグライア賞糖尿病と合併症の成因に対する病態栄養学および分子生物学的解析とその臨床への展開
2017/11 - 日本医師会日本医師会医学賞糖尿病病態の分子生物学的解析と新規糖尿病治療法開発への応用
2016 - ハーゲドーン賞
2015 - 日本体質医学会日本体質医学会学会賞糖尿病病態の体質医学的解析
2014 - ヘルスケア産業づくり貢献大賞「九州経済連合会長賞」受賞 “「ブルーサークルメニュー開発」”

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Association Membership(s) (8)：

日本臨床分子医学会 , 日本肥満学会 , 日本内科学会 , 日本糖尿病学会 , 日本病態栄養学会 , 日本内分泌学会 , 日本体質学会 , 日本体質医学会

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