Osaki Mitsuhiko

オサキミツヒコ | Osaki Mitsuhiko

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Experimental pathology , Human pathology , Cell biology

Research keywords (6)：細胞外小胞 , miRNA , 転移 , 細胞治療 , がん , Apoptosis

Research theme for competitive and other funds (11)：

2022 - 2025 腎癌の術後補助療法に関する患者選別のバイオマーカーとなるmicroRNAの同定
2022 - 2025 変形性関節症の組織学的病態解明に基づく血管新生阻害薬の発展
2016 - 2019 核酸医薬による骨肉腫の肺転移予防法開発に向けた前臨床試験
2013 - 2017 The elucidation of the carcinogenic mechanism of the Down's syndrome using chromosome engineering technology
2011 - 2011 Development of cancer stem cell (CSC) culturing system and identification of CSC-specific marker

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Papers (131)：

Ai Ikebuchi, Mitsuhiko Osaki, Ikumi Wada, Hiroki Nagata, Kei Nagira, Yukihiro Azuma, Futoshi Okada, Tasuku Harada, Fuminori Taniguchi. Increased chemokine ligand 26 expression and its involvement in epithelial-mesenchymal transition in the endometrium with adenomyosis. Journal of gynecology obstetrics and human reproduction. 2023. 52. 9. 102645-102645
Yuki Iida, Mitsuhiko Osaki, Shinya Sato, Runa Izutsu, Heekyung Seong, Masayo Okawa, Daiken Osaku, Hiroaki Komatsu, Fuminori Taniguchi, Futoshi Okada. AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk. Molecular and Clinical Oncology. 2023. 19. 1
Yosuke Hiramuki, Satoshi Abe, Narumi Uno, Kanako Kazuki, Shuta Takata, Hitomaru Miyamoto, Haruka Takayama, Kayoko Morimoto, Shoko Takehara, Mitsuhiko Osaki, et al. Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model. Scientific Reports. 2023. 13. 1
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, et al. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nature communications. 2023. 14. 1. 621-621
Keisuke Goto, Masaki Morimoto, Mitsuhiko Osaki, Akimitsu Tanio, Runa Izutsu, Yoshiyuki Fujiwara, Futoshi Okada. The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients. BMC Cancer. 2022. 22. 1

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MISC (312)：

井筒瑠奈, 尾崎充彦, ソン・ヒギョン, 岡田太. ヒト胃癌細胞由来AMIGO2包含エクソソームは肝微小環境に作用し前転移ニッチェを形成する. 日本病理学会会誌. 2023. 112. 1. 238-238
Seong Heekyung, 井筒瑠奈, 尾崎充彦, 岡田太. AMIGO2発現によるヒト癌細胞の癌幹細胞様形質の制御. 日本病理学会会誌. 2023. 112. 1. 314-314
宮本人丸, 宇野愛海, 高田修汰, 黛亮太, 宮崎夏美, 尾崎充彦, 鈴木輝彦, 押村光雄, 冨塚一磨, 香月康宏, et al. Development of cancer research using novel chromosome transfer and efficient gene loading systems. 日本がん転移学会学術集会・総会プログラム抄録集. 2021. 30th
宇野愛海, 宮本人丸, 高田修汰, 古本真也, 黛亮太, 宮崎夏美, 中山祐二, 尾崎充彦, 半藤千晶, 阿部智志, et al. Application of chromosome engineering technology (1): Construction of a panel of human cell lines containing human/mouse artificial chromosomes for the dissemination of chromosome engineering technology. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
長田佳子, 林一彦, 佐藤幸夫, 尾崎充彦, 桑本聡史, 三明淳一朗, 市原克則, 澤野達哉, 松澤和彦, 今村武史. TRAbs induced by Epstein-Barr virus reactivation injure thyroid follicular epithelial cells. 日本病理学会会誌. 2021. 110. 1

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Patents (5)：

Lectures and oral presentations (2)：

MicroRNA as a novel drug for cancer metastasis: Suppression of lung metastasis of osteosarcoma in in vivo model
(2nd World Conference on Magic Bullets 2008)
Down-regulation of MAD1 (mitotic arrest deficiency 1) in human gastric carcinoma: Correlation with cell proliferation
(4th International Society of Gastroenterological Carcinogenesis Conference 2006)

Works (3)：

Histopathological Study on NBS-1 Knock Out Mice
2001 -
Mechanism of Action in Anticancer drugs in Human ovarian Cancer
2000 -
Expression of Arpp protein in Human Tissues
2000 -

Education (4)：

- 2000 Tottori University
- 2000 Tottori University Graduate School, Division of Medical Sciences
- 1995 Tottori University Faculty of Medicine School of Life Sciences
- 1995 Tottori University Faculty of Medicine

Professional career (2)：

Ph. D. (Tottori University)
M. Sc. (Tottori University)

Awards (4)：

2020/01 - 鳥取大学長表彰(研究功績)
2011/12 - 膵臓病研究奨励賞
2006 - Second Place Poster Presentation 4th International Society of Gastroenterological Carcinogenesis Conference
2005 - Hiroshima Cancer Seminar Best Poster Award

Association Membership(s) (6)：

日本がん転移学会 , 日本分子生物学会 , 日本消化器癌発生学会 , 日本病理学会 , 日本癌学会 , 日本細胞外小胞学会

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