Rchr
J-GLOBAL ID：200901099792326050
Update date: May. 31, 2020
Nomoto Masahiro
ノモト マサヒロ | Nomoto Masahiro
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Affiliation and department：
Meiji Seika Kaisha, Ltd.
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Detailed information
Job title：
Researcher
Research field (1)：
Clinical pharmacy
Research keywords (12)：
トランスポーター
, 毒性学
, 排泄
, 代謝
, 分布
, 吸収
, 薬物動態
, excretion
, metabolism
, distribution
, absorption
, Pharmacokinetics
Research theme for competitive and other funds (3)：
2005 - 2008 胆汁酸誘発肝障害に及ぼすトランスポーター発現量及び胆汁排泄能の影響
2005 - 2008 Effect of transporter and bile excretion on hepatopathy induced bile acid
2005 - 2007 薬物動態学、毒性学
MISC (8)：
Masaaki Miyata, Masahiro Nomoto, Fumiaki Sotodate, Tomohiro Mizuki, Wataru Hori, Miho Nagayasu, Shinya Yokokawa, Shin-ichi Ninomiya, Yasushi Yamazoe. Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis. EUROPEAN JOURNAL OF PHARMACOLOGY. 2010. 636. 1-3. 145-154
Masahiro Nomoto, Tomoko Tatebayashi, Jun Morita, Hisashi Suzuki, Kazumasa Aizawa, Tohru Kurosawa, Izumi Komiya. Physiological Models Are Good Tools to Predict Rat Bioavailability of EF5154 Prodrugs from In Vitro Intestinal Parameters. JOURNAL OF PHARMACEUTICAL SCIENCES. 2009. 98. 4. 1532-1544
Masaaki Miyata, Yoshiki Matsuda, Masahiro Nomoto, Yuki Takamatsu, Nozomi Sato, Mayumi Hamatsu, Paul A. Dawson, Frank J. Gonzalez, Yasushi Yamazoe. Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption. DRUG METABOLISM AND DISPOSITION. 2009. 37. 2. 338-344
NOMOTO Masahiro, NOMOTO Masahiro, MIYATA Masaaki, YIN Shanai, KURATA Yasushi, SHIMADA Miki, YOSHINARI Kouichi, GONZALEZ Frank J, SUZUKI Kokichi, SHIBASAKI Shigeki, et al. Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. Biol Pharm Bull. 2009. 32. 2. 172-178
Masahiro Nomoto, Masaaki Miyata, Miki Shimada, Kouichi Yoshinari, Frank J. Gonzalez, Shigeki Shibasaki, Tohru Kurosawa, Yasuhiro Shindo, Yasushi Yamazoe. ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output. EUROPEAN JOURNAL OF PHARMACOLOGY. 2007. 574. 2-3. 192-200
ｍore...
Education (1)：
- 1989 Tokyo University of Science Graduate School of Pharmaceutical Sciences
Professional career (1)：
薬学博士 (東北大学)
Association Membership(s) (2)：
日本薬物動態学会
, トキシコロジー学会
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