Research keywords (3)：
Immune System
, Thymus
, T lymphocyte
Research theme for competitive and other funds (45)：
2016 - 2019 Positive selection of T cells in the thymic cortex
2014 - 2017 Positive selection dictates T cell-mediated body defense
2012 - 2017 Development and function of thymic microenvironments
2012 - 2017 Analysis and Synthesis of Multidimensional Immune Organ Network
2011 - 2014 Molecular basis for the thymic microenvironments that characterize the immune system
2011 - 2012 The challenge for the development of therapy for autoimmune disorder by the establishment of artificial thymic medullary organ
2010 - 2011 Roles of lymph node stromal cell network in T cell homeostasis
2007 - 2011 Immunological Self Recognition and its Disorders
2007 - 2011 Thymic microenvironments for shaping T cell repertoire
2009 - 2010 胸腺プロテアソームの機能
2009 - 2010 Tリンパ球再選択による自己免疫疾患治療法開発への挑戦
2008 - 2010 Molecular mechanisms that regulate the formation of the thymic microenvironments
2006 - 2007 Cellular dyntarnics and migration during T-Iympharyle development and selection in the thymus
2006 - 2007 胸腺器官発生機構の包括的解析
2006 - 2006 胸腺の器官形成を担う分子ネットワークのマスターマップ作成
2006 - 2006 生体防御と免疫病制御の統合的パラダイム
2005 - 2006 The roles of HIF-1α in T cell-dependent immune responses
2003 - 2006 Thymocyte dynamics and hymus organogenesis
2003 - 2006 Dynamism of immune cells in immune-tissue formation
2003 - 2006 Microenvironments for thymocyte development
2004 - 2005 Molecular mechanism of the thymus organogenesis
2003 - 2005 Molecular mechanisms of cell migration during T-lymphocyte development
2003 - 2003 エチルニトロソウレアによるメダカ変異体の収集に基づく胸腺器官形成機構の解析
2001 - 2003 Immune System Development
2002 - 2002 Tリンパ球の分化選択制御に基づくがん治療法の開発
2001 - 2002 幼若Tリンパ球の「無の選択」から探る新しい細胞内遺伝子産物感知機構
2001 - 2002 Study on the role of histamine H1 receptors in the central nervous system using gene-targeted mouse
2000 - 2002 Molecular signals that regulate the development and movements of developing T lymphocytes
2000 - 2002 リンパ球の系列分岐・運命分岐を決定するシグナル伝達機構
2000 - 2002 Molecular signals for T lymphocyte selection
2001 - 2001 幼若Tリンパ球への遺伝子導入に基づいたがん免疫療法の開発
2000 - 2000 がんの免疫療法のための幼若Tリンパ球への遺伝子導入
1999 - 2000 Mechanisms for differentiation and selection of T, NKT and NK cells
1997 - 2000 Molecular signals for T lymphocyte development and repertoire selection
1999 - 1999 T・Bリンパ球の分化方向決定に遺伝的異常を示すマウス
1999 - 1999 遺伝子導入によるTリンパ球分化促進に基づくエイズ治療法の開発
1999 - 1999 がんの免疫療法のための幼若Tリンパ球への遺伝子導入
1999 - 1999 レパートリー形成の分子機構
1998 - 1999 Expression and function of pT-alpha, a component of pre-TCR
1996 - 1999 T cell selection in the thymus
1996 - 1998 Characterization of the hematopoietic stem cell and search for the molecules responsible for stem cell self-renewal.
1997 - 1997 がんの免疫療法に向けての遺伝子導入によるTリンパ球の分化誘導
1996 - 1997 T細胞の胸腺内分化を制御する新しい表面分子のクローニング
1996 - 1997 Molecular mechanism of T cell differentiation
1987 - 1988 Carachterization of B cell stimulatory factor capable of inducing autoantibody production and its receptor
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Papers (77)：
Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C Kelly, Naozumi Ishimaru, Yousuke Takahama. Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance. Cell Reports. 2024. 43. 4. 114072-114072
Izumi Ohigashi, Andrea J White, Mei-Ting Yang, Sayumi Fujimori, Yu Tanaka, Alison Jacques, Hiroshi Kiyonari, Yosuke Matsushita, Sevilay Turan, Michael C Kelly, et al. Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium. eLife. 2024. 12
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, et al. Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift. Nature Communications. 2022. 13. 1
Fujie R, Kurowarabe K, Yamada Y, Fujiwara K, Hayashi R, Kawahata H, Miyamoto M, Takahama Y, Ohigashi I, HAYASAKA H. An endogenous CCL21-Ser deficiency reduces melanoma growth by an enhanced antitumor immunity. Heliyon. 2022. 9. e19215
Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M Taketo, Yousuke Takahama, Shinji Takada. Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development. eLife. 2022. 11. e69088
Mami Matsuda-Lennikov, Izumi Ohigashi, Yousuke Takahama. Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells. Current Opinion in Immunology. 2022. 77. 102217-102217
