Rchr
J-GLOBAL ID:200901099901088831
Update date: Jan. 30, 2024
Kuwahara Tomomi
クワハラ トモミ | Kuwahara Tomomi
Affiliation and department:
Homepage URL (1):
http://www.med.kagawa-u.ac.jp/faculty/center/igaku_kouza/bunshi_biseibutsu/
Research field (3):
Bacteriology
, Systems genomics
, Genomics
Research keywords (6):
ゲノム
, Bacteroides
, 腸内細菌
, Genomic analysis
, Virulence
, Anearobe
Research theme for competitive and other funds (40):
- 2022 - 2025 腸筋相関を軸としたフェカリバクテリウム菌の抗サルコペニア効果の検証
- 2022 - 2025 障害者(児)支援施設における感染症流行時の事業継続計画(BCP)立案手法の開発
- 2022 - 2024 機能性プロバイオティクスによる疾患治療と予防への挑戦
- 2021 - 2024 漢方薬による腸内細菌叢を介した抗癌薬関連毒性予防効果の機序解明と支持療法への応用
- 2020 - 2023 加齢性骨格筋減少症における腸内フローラ機能の役割
- 2019 - 2022 Match for the infection control system building which aimed at the human society of the psychiatry hospital and the mentally-disabled person facilities
- 2019 - 2022 Study for the reconstitution process of infant gut flora
- 2018 - 2022 A novel immunotherapy for hematological malignancies integrating oncolytic virus therapy and the manipulation of gut microbiota
- 2018 - 2020 Prediction of recovery of microbiome after perturbation by the combination of mathematical analysis and metagenomics
- 2017 - 2020 Analysis of the gut microbe-derived molecular pattern recognized by the serum IgG of ulcerative colitis patients
- 2016 - 2019 It aims at a strong psychiatry department hospital the infection management.
- 2015 - 2018 Regulation and physiological significance of histamine production in Raoultella ornithinolytica
- 2014 - 2017 Role of the sugar metabolism of resident microbiota in the gut homeostasis
- 2014 - 2017 The role of clostridial T-A system
- 2013 - 2017 Production of novel rare sugar gum and study effects on resident bacteria in oral cavity with rare sugar gums
- 2012 - 2015 Analysis of physiological significance of the diversity and the phase-variable regulation of the capsular polysaccharides in Bacteroides
- 2013 - 2014 バクテリアルトランスロケーション下の腸管免疫機構の解明と治療法への展開
- 2011 - 2013 Inhibitory effect of gut commensals against pathogenic organisms
- 2010 - 2012 Evaluation of tight junctions under bacterial translocation for development of treatment
- 2009 - 2011 Regulatory Network for Expression of Antibiotic Tolerance in Pseudomonas aeruginosa
- 2008 - 2010 In vivo analysis of the gene expression of L.reuteri under the presence of glycerol
- 2008 - 2010 Analysis of the unculturable microbial populations in human gut microbiota
- 2005 - 2009 Basic and applied genomics of enterohemorrhagic Escherichia coli and related enteropathogens
- 2006 - 2007 Genome analysis of bacteria inhabiting the mucosal surface of intestine
- 2006 - 2007 Bacteroidesの多様な表層抗原性を生み出すゲノムシステムの解明
- 2005 - 2007 Molecular analysis of anteliotic-tolerance and stress response in adherent bacteria
- 2005 - 2005 Bacteroidesの表層抗原性を制御する部位特異的組換え酵素の同定
- 2003 - 2004 Analysis of infectious factors of Bacteroides fragilis in the compromised host
- 2002 - 2004 ノイラミニダーゼ遺伝子の導入による乳酸菌の機能改良に関する研究
- 2002 - 微生物ゲノム解析
- 2002 - Analysis of Microbiol genomes
- 2000 - 2001 生理活性物質産生腸内フローラによる疾病の予防と治療
- 2000 - 2000 植物成分および機能性腸内菌による大腸発がんの防御機構の研究
- 1999 - 1999 発がん予防における腸内フローラの役割の解明と機能的腸内菌の開発
- 1998 - 1998 発がんとがん予防における腸内フローラの役割の解明と機能的腸内菌の開発
- 1997 - 1998 Bacteroides fragilisのノイラミニダーゼ遺伝子の発現調節
- 1997 - 1997 発がんとがん予防における腸内フローラの役割の解明と機能的腸内菌の開発
- 1996 - 病原性嫌気性菌の病原性遺伝子発現機構
- 1996 - Regulation of expression of Virulence Gene in Pathogenic Anaerobes
- 腸内細菌の宿主生理機能の修飾作用に関する研究
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Papers (105):
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Hotta F, Eguchi H, Kuwahara T, Imaohji H, Shimomura Y, Kusaka S. Disturbances in the ocular surface microbiome by perioperative antimicrobial eye drops. Front Cell Infect Microbiol. 2023. Volume 13 - 2023
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Takayuki Fujii, Haruyuki Nakayama-Imaohji, Aya Tanaka, Hiroto Katami, Kazuya Tanaka, Yoichi Chiba, Machi Kawauchi, Masaki Ueno, Tomomi Kuwahara, Ryuichi Shimono. Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model. Pediatric Surgery International. 2022
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Rei Kajitani, Hideki Noguchi, Yasuhiro Gotoh, Yoshitoshi Ogura, Dai Yoshimura, Miki Okuno, Atsushi Toyoda, Tomomi Kuwahara, Tetsuya Hayashi, Takehiko Itoh. MetaPlatanus: a metagenome assembler that combines long-range sequence links and species-specific features. Nucleic acids research. 2021. 49. 22. e130
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Hisataka Goda, Haruyuki Nakayama-Imaohji, Hitoshi Yamaoka, Ayano Tada, Tamiko Nagao, Tomohiko Fujisawa, A Hajime Koyama, Tomomi Kuwahara. Inactivation of human norovirus by chlorous acid water, a novel chlorine-based disinfectant. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021
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Miad Elahi, Haruyuki Nakayama-Imaohji, Masahito Hashimoto, Ayano Tada, Hisashi Yamasaki, Tamiko Nagao, Tomomi Kuwahara. The Human Gut Microbe Bacteroides thetaiotaomicron Suppresses Toxin Release from Clostridium difficile by Inhibiting Autolysis. Antibiotics (Basel, Switzerland). 2021. 10. 2
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MISC (14):
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堀田 芙美香, 江口 洋, 桑原 知巳, 今大路 治之, 日下 俊次. 次世代シークエンス技術を用いた周術期の眼表面菌叢解析. 日本眼科学会雑誌. 2019. 123. 臨増. 225-225
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Motoo Suzuki, Haruyuki Imaohji, Tomomi Kuwahara. Spore purification of mouse gut derived non-culturable bacterium. GENES & GENETIC SYSTEMS. 2014. 89. 6. 328-328
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江口 洋, 桑原 知巳, 今大路 治之. 眼科領域で分離されるCorynebacteriumの薬剤耐性化状況の全国調査. 感染症学雑誌. 2009. 83. 6. 732-732
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桑原 知巳, 江口 洋, 今大路 治之. 眼結膜由来のコリネバクテリウムにおけるフルオロキノロン感受性. 感染症学雑誌. 2009. 83. 3. 317-317
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江口 洋, 桑原 知巳, 塩田 洋. 日本人の眼表面から分離されるCorynebacteriumの薬剤耐性化状況全国調査. 日本眼科学会雑誌. 2009. 113. 臨増. 321-321
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Books (2):
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感染と生体防御
建帛社 2012 ISBN:9784767904467
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シンプル微生物学
南江堂 2011 ISBN:9784524262076
Lectures and oral presentations (3):
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腸管内における宿主微生物間相互作用に関わる分子の検索
(第86回日本細菌学会総会、ワークショップ「細菌間および細菌宿主間の相互作用」 2013)
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Bacteroides thetaiotaomicronにおけるマリナートランスポゾン挿入変異ライブラリーの開発
(第35回日本分子生物学会年会 2012)
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腸管内常在菌によるClostridium difficileの病原性抑制機構
(第35回日本分子生物学会年会 2012)
Works (1):
-
新規塩素系殺菌剤の開発と実用化に関する研究
2011 - 2012
Education (2):
- - 1993 The University of Tokushima Faculty of Medicine
- - 1993 The University of Tokushima Faculty of Medicine
Professional career (2):
Work history (6):
- 2011 - - 香川大学医学部, 教授
- 2001 - 2004 The University of Tokushima Faculty of Medicine
- 2004 - - 徳島大学大学院ヘルスバイオサイエンス研究部, 助教授
- 1994 - 2001 The University of Tokushima Faculty of Medicine
- 1993 - 1994 The University of Tokushima Faculty of Medicine
- The University of Tokushima Institute of Health Biosciences The University of Tokushima Graduate School, Department of Moleculor Beateriology
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Awards (1):
Association Membership(s) (6):
日本環境変異原学会
, 日本癌学会
, 日本感染症学会
, 日本分子生物学会
, 日本細菌学会
, 日本内科学会
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