Rchr
J-GLOBAL ID：200901099920641495   Update date: Mar. 09, 2025

Hagiwara Ken'ichi

ハギワラ ケンイチ | Hagiwara Ken'ichi
Affiliation and department：
National Institute of Infectious Diseases Department of Biochemistry and Cell Biology

About National Institute of Infectious Diseases Department of Biochemistry and Cell Biology


Job title： Laboratory of Biomacromolecule Analysis
Homepage URL  (1)： http://www.nih.go.jp/niid/ja/from-biochem/2294-1st-laboratory-home.html
Research field  (5)： Virology ,  Pharmaceuticals - analytical and physicochemistry ,  Pharmaceuticals - health and biochemistry ,  Neuroscience - general ,  Molecular biology
Research keywords  (5)： prion ,  neurodegenerative diseases ,  neurochemistry ,  bioactive peptides ,  analytical chemistry
Research theme for competitive and other funds  (18)：
  • 2018 - 2021 Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold model
  • 2017 - 2020 食品を介する家畜・家禽疾病のリスク管理に関する研究
  • 2014 - 2017 非定型BSE(牛海綿状脳症)に対する安全対策等に関する研究
  • 2011 - 2014 食品を介する伝達性海綿状脳症のリスクと対策等に関する研究
  • 2008 - 2011 食品を介するBSEリスクの解明等に関する研究
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Papers (49)：
  • Hiroaki Shibata, Fumiko Ono, Yuko Sato, Keiko Ohto, Nozomi Nakano, Morikazu Imamura, Motohiro Horiuchi, Minoru Tobiume, Ken'ichi Hagiwara. Lack of Evidence for Transmission of Atypical H-Type Bovine Spongiform Encephalopathy Prions (H-BSE Prions) by Intracranial and Oral Challenges to Nonhuman Primates. Microbiology and immunology. 2025. 69. 1. 25-34
  • Yuko Okemoto-Nakamura, Isei Tanida I, Toshiyuki Yamaji, Kentaro Hanada, Ken'ichi Hagiwara. A PRNP-Disrupted Human Neuroblastoma Cell Line and Its Stable Transformants Expressing Prion Protein Variants. BPB Reports. 2019. 2. 5. 73-79
  • Ken’ichi Hagiwara, Yuko Sato, Yoshio Yamakawa, Hideyuki Hara, Minoru Tobiume, Yuko Okemoto-Nakamura, Tetsutaro Sata, Motohiro Horiuchi, Hiroaki Shibata, Fumiko Ono. Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys. PLOS ONE. 2019. 14. 5. e0216807-e0216807
  • Ken'ichi Hagiwara, Yoshifumi Iwamaru, Naoko Tabeta, Takashi Yokoyama, Minoru Tobiume. Evaluation of rapid post-mortem test kits for bovine spongiform encephalopathy (BSE) screening in Japan: Their analytical sensitivity to atypical BSE prions. Prion. 2017. 11. 2. 113-127
  • H. Hara, Y. Okemoto-Nakamura, F. Shinkai-Ouchi, K. Hanada, Y. Yamakawa, K. Hagiwara. Mouse prion protein (PrP) segment 100 to 104 regulates conversion of PrPC to PrPSc in prion-Infected neuroblastoma cells. Journal of Virology. 2012. 86. 10. 5626-5636
ｍore...
MISC (24)：
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Books (4)：
  • 分析試料前処理ハンドブック[中村 洋編]
    丸善 2003
  • 機器分析ガイドブック[日本分析化学会編]
    丸善 1997
  • 内分泌生理化学[矢内原 昇編]
    南江堂 1994
  • (続)生化学実験講座2 タンパク質の化学(上)[日本生化学会編]
    1987
Professional career (1)：
  • PhD (Pharmaceutical Sciences)
Work history (6)：
  • 2021/04 - 現在 National Institute of Infectious Diseases
  • 2006/04 - 2021/03 National Institute of Infectious Diseases
  • 2001 - 2006 National Institute of Infectious Diseases
  • 1997 - 2000 科学技術振興事業団 「脳を知る」 東京大学 理学系研究科 博士研究員
  • 1995 - 1997 英・オクスフォード大学 博士研究員
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Committee career (2)：
  • 2006/04 - 2021/03 Ministry of Health, Labour and Welfare Members of the expert committee for the testing of bovine spongiform encephalopathy
  • 2014/01 - 2020/12 The Japanese Society for Bacteriology, The Japanese Society for Virology, and The Japanese Society for Host Defense Research. Editorial Board, Microbiology and Immunology
Association Membership(s) (1)：
日本生化学会
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