Characterization of the structure of the anthramycin-d(ATGCAT)<sub>2</sub> adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA, and effect on local DNA structure.

BOYD F L; CHEATHAM S F; REMERS W; HILL G C; HURLEY L H

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J-GLOBAL ID：200902000018969272 Reference number：90A0479604

Characterization of the structure of the anthramycin-d(ATGCAT)₂ adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA, and effect on local DNA structure.

NMR及び分子モデル実験によるアントラマイシン-d(ATGCAT)₂付加体の構造の特性共有結合部位の立体化学の決定,DNAの微小溝における配向及び局部DNA構造に対する効果

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Author (5)： , , , ,
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Volume： 112 Issue： 9 Page： 3279-3289 Publication year： Apr. 25, 1990
JST Material Number： C0254A ISSN： 0002-7863 CODEN： JACSAT Document type： Article
Article type：原著論文 Country of issue： United States (USA) Language： ENGLISH (EN)

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Basic research of antitumor(=antineoplastic)antibiotics

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Characterization of the structure of the anthramycin-d(ATGCAT)2 adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA, and effect on local DNA structure.

Characterization of the structure of the anthramycin-d(ATGCAT)₂ adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA, and effect on local DNA structure.