Art

J-GLOBAL ID：200902000832003966   Reference number：90A0638266

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

チューブリンの重合を阻害する新しいクラスの抗有糸分裂性抗癌薬,2-スチリルキナゾリン-4(3H)-オン類の合成および生物学的評価

Author (6)： JIANG J B (E.I. du Pont de Nemours and Co., Delaware) ,  HESSON D P (E.I. du Pont de Nemours and Co., Delaware) ,  DUSAK B A (E.I. du Pont de Nemours and Co., Delaware) ,  DEXTER D L (E.I. du Pont de Nemours and Co., Delaware) ,  KANG G J (National Inst. Health, Maryland) ,  HAMEL E (National Inst. Health, Maryland)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 33  Issue： 6  Page： 1721-1728  Publication year： Jun. 1990 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： hydroquinazolines ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Pyrimidines  (CF07103W)

Substance index (35)： 2-[(E)-2-Phenylethenyl]-6-chloroquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-5-chloroquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-7-chloroquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-8-chloroquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-bromoquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-iodoquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-fluoroquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-aminoquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]quinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-methylquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-7-chloro-6-fluoroquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6,7-dimethoxyquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-5-methylquinazolin-4(3H)-one ,  6-Methoxy-2-[(E)-styryl]quinazoline-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-hydroxyquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-fluoro-7-(1-piperidinyl)quinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-ethoxyquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-fluoro-7-(4-methyl-1-piperazinyl)quinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-7-methoxyquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-acetyloxyquinazolin-4(3H)-one ,  2-[(E)-2-Phenylethenyl]-6-(2-aminobenzoyloxy)quinazolin-4(3H)-one ,  6-Chloro-2-[(E)-1-propenyl]quinazolin-4(3H)-one ,  2-[(E)-1-Propenyl]quinazolin-4(3H)-one ,  6-Chloro-2-[2-(4-methyl-1-piperazinyl)-2-phenylethyl]quinazolin-4(3H)-one ,  6-Chloro-2-(2-morpholino-2-phenylethyl)quinazolin-4(3H)-one ,  2-Methyl-6-chloro-4(3H)-quinazolinone ,  6-Chloro-2-phenylethynylquinazolin-4(3H)-one ,  6-Chloro-2-(2-phenylethyl)quinazolin-4(3H)-one ,  6-Chloro-2-benzylquinazolin-4(3H)-one ,  6-Chloro-2-[(E)-2-(2-pyridinyl)ethenyl]quinazolin-4(3H)-one ,  6-Methoxy-2-[2-(1-piperidinyl)-2-phenylethyl]quinazolin-4(3H)-one ,  3-Amino-6-chloro-2-[(E)-2-phenylethenyl]quinazolin-4(3H)-one ,  6-Chloro-2-[(E)-2-phenylethenyl]quinazoline-4(3H)-thione ,  6-Chloro-4-(4-diethylamino-1-methylbutylamino)-2-[(E)-2-phenylethenyl]quinazoline ,  7-Chloro-3-[(E)-2-phenylethenyl]-2H-1,2,4-benzothiadiazine 1,1-dioxide

Terms in the title (6)： チューブリン ,  重合 ,  阻害 ,  クラス ,  抗癌薬 ,  生物学的評価