Art

J-GLOBAL ID：200902005655657170   Reference number：92A0819256

Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents.

抗腫よう剤 I ポドフィロトキシン誘導体のDNAトポイソメラーゼII阻害活性及び抗腫よう剤としての構造相関

Author (9)： TERADA T (Taiho Pharmaceutical Co., Ltd., Saitama, JPN) ,  FUJIMOTO K (Taiho Pharmaceutical Co., Ltd., Saitama, JPN) ,  NOMURA M (Taiho Pharmaceutical Co., Ltd., Saitama, JPN) ,  YAMASHITA J (Taiho Pharmaceutical Co., Ltd., Saitama, JPN) ,  WIERZBA K (Taiho Pharmaceutical Co., Ltd., Saitama, JPN) ,  YAMADA Y (Taiho Pharmaceutical Co., Ltd., Saitama, JPN) ,  KOBUNAI T (Taiho Pharmaceutical Co., Ltd., Tokushima, JPN) ,  TAKEDA S (Taiho Pharmaceutical Co., Ltd., Tokushima, JPN) ,  YAMAGUCHI H (Osaka Univ. Pharmaceutical Sciences, Osaka, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 40  Issue： 10  Page： 2720-2727  Publication year： Oct. 1992 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： structure-activity relationship ,...
Semi thesaurus term： デスオキシポドフィロトキシン ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (23)： Podophyllotoxin ,  Deoxypodophyllotoxin ,  Epipodophyllotoxin ,  4'-Demethyldeoxypodophyllotoxin ,  (5R)-5β-[3,4-Dihydroxy-5-methoxyphenyl]-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-[(Diethoxyphosphinyl)oxy]-3,5-dimethoxyphenyl]-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-[(tert-Butyldimethylsilyl)oxy]-3,5-dimethoxyphenyl]-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-Benzyloxy-3,5-dimethoxyphenyl]-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-Hydroxy-3,5-dimethoxyphenyl]-9α-(3-hydroxypropoxy)-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  4-O-Ethyl-4′-demethylepipodophyllotoxin ,  (5R)-5β-[4-Hydroxy-3,5-dimethoxyphenyl]-9α-[2-(diethoxyphosphinyl)ethoxy]-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-Hydroxy-3,5-dimethoxyphenyl]-9α-(2,3,4-trihydroxybutoxy)-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-Hydroxy-3,5-dimethoxyphenyl]-9α-(2,3-dihydroxypropoxy)-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-Hydroxy-3,5-dimethoxyphenyl]-9α-(3-dimethylamino-2-hydroxypropoxy)-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  (5R)-5β-[4-Hydroxy-3,5-dimethoxyphenyl]-9α-[(1-methyl-2-pyrrolidinyl)methoxy]-5,8,8aβ,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ,  RD-4-6283 ,  6,7-Dihydroxy-9β-[4-hydroxy-3,5-dimethoxyphenyl]-3aβ,4,9,9aα-tetrahydronaphtho[2,3-c]furan-1(3H)-one ,  4α,6,7-Trihydroxy-9β-[3,4,5-trimethoxyphenyl]-3aβ,4,9,9aα-tetrahydronaphtho[2,3-c]furan-1(3H)-one ,  4α,6,7-Trihydroxy-9β-[4-hydroxy-3,5-dimethoxyphenyl]-3aβ,4,9,9aα-tetrahydronaphtho[2,3-c]furan-1(3H)-one ,  4α-Ethoxy-6,7-dihydroxy-9β-[3,4,5-trimethoxyphenyl]-3aβ,4,9,9aα-tetrahydronaphtho[2,3-c]furan-1(3H)-one ,  4α-Ethoxy-6,7-dihydroxy-9β-[4-hydroxy-3,5-dimethoxyphenyl]-3aβ,4,9,9aα-tetrahydronaphtho[2,3-c]furan-1(3H)-one ,  [2-[[[(5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-5,5aα,6,8,8aβ,9-hexahydro-6-oxofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole]-9α-yl]oxy]ethyl]dimethylsulfonium・tosylate ,  [3-[[[(5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-5,5aα,6,8,8aβ,9-hexahydro-6-oxofuro[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole]-9α-yl]oxy]propyl]dimethylsulfonium・tosylate

Reference (34)：

• 1) L.S. King and M.S. Sullivan, Science, 104, 244 (1946).
• 2) W.J. Gensler, C.A. Murthy, and M.H. Trannell, J. Med. Chem., 20, 635 (1977)
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Terms in the title (6)： 抗腫よう剤 ,  ポドフィロトキシン ,  誘導体 ,  DNAトポイソメラーゼII ,  阻害活性 ,  相関