Art

J-GLOBAL ID：200902015518215255   Reference number：91A0303572

Synthesis and anticancer activity of various 3′-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-β-D-threo-pentofuranosyl)cytosine.

種々な3′-デオキシピリミジンヌクレオシド類似体の合成と抗癌活性および1-(3-デオキシ-β-D-threo-ペントフラノシル)シトシンの結晶構造

Author (9)： LIN T-S (Yale Univ. School of Medicine, Connecticut) ,  YANG J-H (Yale Univ. School of Medicine, Connecticut) ,  LIU M-C (Yale Univ. School of Medicine, Connecticut) ,  SHEN Z-Y (Yale Univ. School of Medicine, Connecticut) ,  BIRNBAUM G I (National Research Council of Canada, Ottawa, CAN) ,  GIZIEWICZ J (Bureau of Human Prescription Drugs, Health and Welfare Canada, Ontario, CAN) ,  GHAZZOULI I (Bristol-Myers Squibb Pharmaceutical Research and Development Division, Connecticut) ,  BRANKOVAN V (Oncogen, Washington) ,  HSIUNG G-D (Yale Univ. School of Medicine, Connecticut)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 2  Page： 693-701  Publication year： Feb. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： amidine ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=91A0303572&from=J-GLOBAL&jstjournalNo=D0102A") }}

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of antiviral drugs  (GW17040O)

Substance index (13)： 3′-Deoxy-ara-C ,  3'-Deoxyuridine ,  3′-Deoxy-5-bromouridine ,  3'-Deoxycytidine ,  3′-Deoxy-5-bromocytidine ,  3′-Deoxy-5-iodocytidine ,  1-(5-O-Acetyl-3-deoxy-β-D-threo-pentofuranosyl)cytosine ,  N-Acetyl-1-(2-O,5-O-diacetyl-3-deoxy-β-D-threo-pentofuranosyl)cytosine ,  N-Acetyl-1-(2-O-acetyl-3-deoxy-β-D-threo-pentofuranosyl)cytosine ,  1-(3-Deoxy-β-D-threo-pentofuranosyl)uracil ,  1-(3-Deoxy-β-D-threo-pentofuranosyl)-5-chlorouracil ,  1-(3-Deoxy-β-D-threo-pentofuranosyl)-5-bromouracil ,  1-(3-Deoxy-β-D-threo-pentofuranosyl)-5-iodouracil

Terms in the title (4)： 類似体 ,  抗癌活性 ,  シトシン ,  結晶構造