Art

J-GLOBAL ID：200902015882030961   Reference number：91A0626540

Oxidation of Dihydropyridine Calcium Channel Blockers and Analogues by Human Liver Cytochrome P-450 IIIA4.

ジヒドロピリジン系カルシウムチャンネル遮断薬と同族体のヒト肝チトクロームP-450IIIA4による酸化

Author (6)： GUENGERICH F P (Vanderbilt Univ. School of Medicine, Tennessee) ,  BRIAN W R (Vanderbilt Univ. School of Medicine, Tennessee) ,  IWASAKI M (Vanderbilt Univ. School of Medicine, Tennessee) ,  SARI M-A (Vanderbilt Univ. School of Medicine, Tennessee) ,  BAEAERNHIELM C (AB Haessle, Moelndal, SWE) ,  BERNTSSON P (AB Haessle, Moelndal, SWE)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 6  Page： 1838-1844  Publication year： Jun. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： calcium channel blocker ,...

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JST classification (2)： 生物薬剤学  (GY01020D) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (41)： Nifedipine ,  Nitrendipine ,  Niludipine ,  Nisoldipine ,  Nimodipine ,  Nicardipine ,  Felodipine ,  1,4-Dihydro-2,6-dimethyl-4-(4-chloro-3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  Denitronifedipin ,  1,4-Dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinedicarboxylic acid diethyl ester ,  1,4-Dihydro-2,6-dimethyl-4-(1-naphthalenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  1,4-Dihydro-2,6-dimethyl-4-(3-chlorophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  1,4-Dihydro-2,6-dimethyl-4-(2,3,5,6-tetrafluorophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  1,4-Dihydro-2,6-dimethyl-4-(4-trifluoromethylphenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  1,4-Dihydro-2,6-dimethyl-4-(2-methoxyphenyl)pyridine-3,5-dicarboxylic acid diethyl ester ,  1,4-Dihydro-2,6-dimethyl-4-(3-cyanophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester ,  DDEP ,  Dehydronifedipine ,  2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-ethyl 3-methyl ester ,  2,6-Dimethyl-4-(4-chloro-3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  2,6-Dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-(2-isopropyloxyethyl)5-(3-methylbutyl) ester ,  2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-methylpropyl) ester ,  BAY-m-9822 ,  2,6-Dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-(methylbenzylamino)ethyl]5-methyl ester ,  2,6-Dimethyl-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester ,  Diethyl 2,6-dimethyl-4-phenyl-3,5-pyridinedicarboxylate ,  2,6-Dimethyl-4-(1-naphthalenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  2,6-Dimethyl-4-(3-chlorophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  Dehydrofelodipine ,  2,6-Dimethyl-4-(2,3,5,6-tetrafluorophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  2,6-Dimethyl-4-(4-trifluoromethylphenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  2,6-Dimethyl-4-(2-methoxyphenyl)-3,5-pyridinedicarboxylic acid diethyl ester ,  2,6-Dimethyl-4-(3-cyanophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester ,  2,6-Dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester ,  2,6-Dimethyl-4-ethylpyridine-3,5-dicarboxylic acid diethyl ester ,  (+)-BAY-k-8644 ,  (-)-BAY-k-8644 ,  K-8644 ,  1,2,6-Trimethyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylic acid dimethyl ester ,  1,2,6-Trimethyl-3,5-bis(methoxycarbonyl)-4-phenylpyridinium

Terms in the title (5)： ジヒドロピリジン ,  カルシウムチャンネル遮断薬 ,  同族体 ,  ヒト ,  酸化