Art

J-GLOBAL ID：200902020937553326   Reference number：83A0411590

Synthesis and biological properties of sodium (5R,6S,8R)-6α-hydroxyethyl-2-carbamoyloxymethyl-2-penem-3-carboxylate (FCE 22101) and its orally absorbed esters FCE 22553 and FCE 22891.

ソジュウム(5R,6S,8R)-6α-ヒドロキシエチル-2-カルバモイルオキシメチル-2-ペネム-3-カルボキシレート(FCE22101)とその経口吸収エステルFCE22553とFCE22891の合成および生物学的性質

Author (9)： FRANCESCHI G (Farmitalia Carlo Erba SpA, Italy) ,  FOGLIO M (Farmitalia Carlo Erba SpA, Italy) ,  ALPEGIANI M (Farmitalia Carlo Erba SpA, Italy) ,  BATTISTINI C (Farmitalia Carlo Erba SpA, Italy) ,  BEDESCHI A (Farmitalia Carlo Erba SpA, Italy) ,  PERRONE E (Farmitalia Carlo Erba SpA, Italy) ,  ZARINI F (Farmitalia Carlo Erba SpA, Italy) ,  ARCAMONE F (Farmitalia Carlo Erba SpA, Italy) ,  BRUNA C D (Farmitalia Carlo Erba SpA, Italy)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 36  Issue： 7  Page： 938-941  Publication year： Jul. 1983 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cephalosporins ,...
Semi thesaurus term： FCE22891 ,...

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JST classification (1)： Synthesis of antibiotics  (GX04000Z)

Reference (8)：

• 1) FRANCESCHI, G.; M. FOGLIO, F. ARCAMONE, A.SANFILIPPO & G. SCHIOPPACASSI: Antibacterialactivity of novel broad spectrum "(5<i>R</i>)-penem"derivatives. J. Antibiotics 33: 453-454, 1980
• 2) SANFILIPPO, A.; C. DELLA BRUNA, D. JABES, E.MORVILLO, G. SCHIOPPACASSI, G. FRANCESCHI,F. ARCAMONE, C. BATTISTINI, M. FOGLIO & F.ZARINI: Biological activity of (5<i>R</i>,6<i>S</i>,8<i>R</i>)-6-α-hydroxyethyl-2-acetoxymethyl-2-penem-3-carboxylate.J. Antibiotics 35: 1248-1251, 1982
• 3) "An oral penem antibiotic: SCH 29482". Anti-microb.Chemother. 9 Suppl. C: 1-245, 1982
• 4) HAYASHI, T.; A. YOSHIDA, N. TAKEDA, S. OIDA,S. SUGAWARA & E. OHKI: 2-(Alkylthio)penem-3-carboxylic acids. V. Synthesis and antibacterialactivities of "1-thiathienamycin" and relatedcompounds. Chem. Pharm. Bull. 29:3158-3172, 1981
• 5) DELLA BRUNA, C.; D. JABES, A. SANFILIPPO, G.SCHIOPPACASSI, F. ARCAMONE, M. FOGLIO & G.FRANCESCHI: FCE 22101 anew broad spectrumpenem derivative. 22 nd Intersci. Conf. Anti-microb.Agents Chemother., Abstract 216, Miami,Oct. 1982

Terms in the title (5)： ペネム ,  カルボキシレート ,  経口吸収 ,  エステル ,  生物学的性質