FK409, a novel vasodilator isolated from the acid-treated fermentation broth of streptomyces griseosporeus. II. Structure of FK409 and its precursor FR-900411.

HINO M; ANDO T; TAKASE S; ITOH Y; OKAMOTO M; KOHSAKA M; AOKI H; IMANAKA H

Art

J-GLOBAL ID：200902027738742017 Reference number：90A0052630

FK409, a novel vasodilator isolated from the acid-treated fermentation broth of streptomyces griseosporeus. II. Structure of FK409 and its precursor FR-900411.

FK409,Streptomyces griseosporeusの酸処理発酵液から単離した新規血管拡張剤 II FK409の構造と前駆物質FR-900411

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Material：
Volume： 42 Issue： 11 Page： 1584-1588 Publication year： Nov. 1989
JST Material Number： G0489A ISSN： 0021-8820 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic research of vasoactive drugs and hypotensive drugs , Other natural substances of biological origin , Antibiotics in general

Reference (5)：

1) HINO, M.; M. IWAMI, M. OKAMOTO, K. YOSHIDA, H. HARUTA, M. OKUHARA, J. HOSODA, M. KOHSAKA, H. AOKI & H. IMANAKA: FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiotics 42: 1578-1583, 1989
2) KURD, C. D. & M. E. NILSON: Aliphatic nitro ketones. J. Org. Chem. 20: 927-936, 1955
3) ROOMI, M. W. & H. DUGAS: Nuclear magnetic resonance study of carbethoxypyrroles. Can. J. Chem. 48: 2303-2305, 1970
5) ROTHSTEIN, E. & W. G. SCHOFIELD: The elimination of carbon monoxide from acid derivatives. Part II. Friedel-crafts reactions (i) with α,α-dialkylglutaric anhydrides, (ii) involving cyclisation with elimination. J. Chem. Soc. Chem. Commun. 1965: 4566-4576, 1965

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