FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

KINO T; HATANAKA H; HASHIMOTO M; NISHIYAMA M; GOTO T; OKUHARA M; KOHSAKA M; AOKI H; IMANAKA H

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J-GLOBAL ID：200902032858829667 Reference number：88A0061154

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

FK-506,Streptomycesから単離した新規の免疫抑制剤 I 培養,単離,物理化学的および生物学的特性

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Material：
Volume： 40 Issue： 9 Page： 1249-1255 Publication year： Sep. 1987
JST Material Number： G0489A ISSN： 0021-8820 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic research of antibiotics acting on pathogenic organisms , Basic research of immunotherapeutic agents and blood preparations

Reference (15)：

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2) CALNE, R. Y.; D. J. G. WHITE, D. B. EVANS, S. THIRU, R. G. HENDERSON, D. V. HAMILTON, K. ROLLES, P. MCMASTER, T. J. DUFFY, B. R. D. MACDOUGALL & R. WILLIAMS: Cyclosporin A in cadaveric organ transplantation. Br. Med. J. 282: 934-936,1981
3) CALNE, R. Y.; K. ROLLES, D. J. G. WHITE, S. THIRU, D. B. EVANS, P. MCMASTER, D. C. DUNN, G. N. CRADDOCK, R. G. HENDERSON, S. Aziz & P. LEWIS: Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet 1979-11: 1033- 1036, 1979
4) STARZL, T. E.; G. B. G. KINTMALM, K. A. PORTER, S. IWATSUKI & G. P. J. SCHROTER: Liver transplantation with use of Cyclosporin A and prednisone. N. Engl. J. Med. 305: 266⇔9, 1981
5) BRITTON, S. & R. PALACIOS: Cyclosporin A - Usefulness, risks and mechanism of action. Immunol. Rev. 65:5-22, 1982

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