Art

J-GLOBAL ID：200902032858829667   Reference number：88A0061154

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

FK-506,Streptomycesから単離した新規の免疫抑制剤 I 培養,単離,物理化学的および生物学的特性

Author (9)： KINO T (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  HATANAKA H (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  HASHIMOTO M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  NISHIYAMA M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  GOTO T (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  OKUHARA M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  KOHSAKA M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  AOKI H (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  IMANAKA H (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 40  Issue： 9  Page： 1249-1255  Publication year： Sep. 1987 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Streptomyces ,...
Semi thesaurus term： antifungal activity ,...

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JST classification (2)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Reference (15)：

• 1) BOREL, J. F.; C. FEURER, C. MAGNEE & H. STAHELIN: Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 32: 1017-1025, 1977
• 2) CALNE, R. Y.; D. J. G. WHITE, D. B. EVANS, S. THIRU, R. G. HENDERSON, D. V. HAMILTON, K. ROLLES, P. MCMASTER, T. J. DUFFY, B. R. D. MACDOUGALL & R. WILLIAMS: Cyclosporin A in cadaveric organ transplantation. Br. Med. J. 282: 934-936,1981
• 3) CALNE, R. Y.; K. ROLLES, D. J. G. WHITE, S. THIRU, D. B. EVANS, P. MCMASTER, D. C. DUNN, G. N. CRADDOCK, R. G. HENDERSON, S. Aziz & P. LEWIS: Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet 1979-11: 1033- 1036, 1979
• 4) STARZL, T. E.; G. B. G. KINTMALM, K. A. PORTER, S. IWATSUKI & G. P. J. SCHROTER: Liver transplantation with use of Cyclosporin A and prednisone. N. Engl. J. Med. 305: 266⇔9, 1981
• 5) BRITTON, S. & R. PALACIOS: Cyclosporin A - Usefulness, risks and mechanism of action. Immunol. Rev. 65:5-22, 1982

Terms in the title (6)： FK-506 ,  Streptomyces ,  単離 ,  免疫抑制剤 ,  培養 ,  生物学的特性