Art

J-GLOBAL ID：200902039921300021   Reference number：90A0330421

Hydroxamic acid inhibitors of 5-lipoxygenase. Quantitative structure-activity relationships.

5-リポキシゲナーゼのヒドロキサム酸系阻害薬 定量的構造活性相関

Author (8)： SUMMERS J B (Abbott Lab., Illinois) ,  KIM K H (Abbott Lab., Illinois) ,  MAZDIYASNI H (Abbott Lab., Illinois) ,  HOLMS J H (Abbott Lab., Illinois) ,  RATAJCZYK J D (Abbott Lab., Illinois) ,  STEWART A O (Abbott Lab., Illinois) ,  DYER R D (Abbott Lab., Illinois) ,  CARTER G W (Abbott Lab., Illinois)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 33  Issue： 3  Page： 992-998  Publication year： Mar. 1990 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： phenol ether ,...
Semi thesaurus term： benzoic acids ,...

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JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Nitrogen derivatives of aromatic monocyclic carboxylic acids  (CF05200S)

Substance index (67)： 4-Nitrobenzohydroximic acid ,  N-Hydroxy-4-cyanobenzamide ,  4-Trifluoromethylbenzohydroximic acid ,  4-Bromobenzhydroximic acid ,  4-Iodobenzohydroximic acid ,  4-Phenylbenzohydroximic acid ,  4-Methylbenzohydroximic acid ,  4-Hydroxybenzohydroxamic acid ,  4-Aminobenzhydroximic acid ,  Benzohydroxamic acid ,  4-(2-Methylpropyl)benzohydroximic acid ,  4-(2,4,6-Trimethylphenyl)benzohydroximic acid ,  4-(1-Naphthalenyl)benzohydroximic acid ,  4-(2-Naphthalenyl)benzohydroximic acid ,  4-(2-Nitrophenyl)benzohydroximic acid ,  3-Phenylbenzohydroximic acid ,  3-Benzoylbenzohydroximic acid ,  Salicylhydroxamic acid ,  N-Methyl-N-hydroxybenzamide ,  4-Butoxy-N-methylbenzohydroxamic acid ,  N-Methyl-4-(2,4,6-trimethylphenyl)benzohydroxamic acid ,  N-Hydroxy-1-naphthamide ,  2-Naphthohydroxamic acid ,  1-Hydroxynaphthalene-2-carbohydroximic acid ,  3-Hydroxynaphthalene-2-carbohydroxamic acid ,  6-Methoxynaphthalene-2-carbohydroximic acid ,  6-(2-Propenyloxy)naphthalene-2-carbohydroximic acid ,  6-Butoxynaphthalene-2-carbohydroximic acid ,  6-Hexyloxynaphthalene-2-carbohydroximic acid ,  6-Heptyloxynaphthalene-2-carbohydroximic acid ,  6-(3-Nonenyloxy)naphthalene-2-carbohydroximic acid ,  N-Methylnaphthalene-2-carbohydroxamic acid ,  6-Butoxy-N-methylnaphthalene-2-carbohydroxamic acid ,  Anthracene-2-carbohydroximic acid ,  Phenanthrene-2-carbohydroximic acid ,  Phenanthrene-3-carbohydroximic acid ,  9,10-Dihydrophenanthrene-3-carbohydroximic acid ,  1H-Indole-3-carbohydroximic acid ,  N-Hydroxycinnamamide ,  (Z)-3-Phenyl-2-propenehydroximic acid ,  (E)-3-[3-Phenylphenyl]-N-methyl-2-propenehydroxamic acid ,  (E)-3-[4-Phenylphenyl]-N-methyl-2-propenehydroxamic acid ,  A-61442 ,  (E)-3-[4-Butoxyphenyl]-N-methyl-2-propenehydroxamic acid ,  (E)-3-[4-Benzyloxyphenyl]-N-methyl-2-propenehydroxamic acid ,  (E)-3-(1-Naphthalenyl)-2-propenehydroximic acid ,  (E)-3-(4-Nitro-1-naphthalenyl)-2-propenehydroximic acid ,  (E)-3-(2-Naphthalenyl)-2-propenehydroximic acid ,  (E)-3-(2-Naphthalenyl)-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-N-isopropyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-N-cyclohexyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-N-phenyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-N-(4-methylphenyl)-2-propenehydroxamic acid ,  (E)-3-(3-Nitro-2-naphthalenyl)-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-2-methyl-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-2-phenyl-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-2-(4-fluorophenyl)-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-2-(4-chlorophenyl)-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-2-(4-bromophenyl)-N-methyl-2-propenehydroxamic acid ,  (E)-2-Methyl-3-(2-naphthalenyl)-2-propenehydroximic acid ,  2,3,3-Triphenyl-N-methyl-2-propenehydroxamic acid ,  (E)-3-(2-Naphthalenyl)-3,N-dimethyl-2-propenehydroxamic acid ,  (E)-3-[(9,10-Dihydro-9,10-dioxoanthracen)-2-yl]-N-methyl-2-propenehydroxamic acid ,  (E)-3-(Phenanthren-9-yl)-N-methyl-2-propenehydroxamic acid ,  N-Hydroxy-3-phenylpropiolamide ,  N-Hydroxyphenylacetamide ,  Bufexamac

Terms in the title (4)： 5-リポキシゲナーゼ ,  ヒドロキサム酸 ,  阻害薬 ,  定量的構造活性相関