Art

J-GLOBAL ID：200902040990831568   Reference number：91A0303562

Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.

カルシウム非依存スルホジエステラーゼ阻害薬キナゾリンジオン類の構造活性相関

Author (9)： LOWE J A III (Pfizer, Inc., Connecticut) ,  ARCHER R L (Pfizer, Inc., Connecticut) ,  CHAPIN D S (Pfizer, Inc., Connecticut) ,  CHENG J B (Pfizer, Inc., Connecticut) ,  HELWEG D (Pfizer, Inc., Connecticut) ,  JOHNSON J L (Pfizer, Inc., Connecticut) ,  KOE B K (Pfizer, Inc., Connecticut) ,  LEBEL L A (Pfizer, Inc., Connecticut) ,  SHIRLEY J T (Pfizer, Inc., Connecticut)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 2  Page： 624-628  Publication year： Feb. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： tranquilizer ,...

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JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of psychotropic drugs  (GW03100Y) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (10)： Rolipram ,  3-[(3-Ethyl-1,2,3,4-tetrahydro-2,4-dioxoquinazolin)-1-yl]benzoic acid methyl ester ,  3-[(1,2,3,4-Tetrahydro-2,4-dioxoquinazolin)-1-yl]benzoic acid methyl ester ,  3-[(3-Benzyl-1,2,3,4-tetrahydro-2,4-dioxoquinazolin)-1-yl]benzoic acid methyl ester ,  3-[(3-Benzyl-1,2,3,4-tetrahydro-2,4-dioxoquinazolin)-1-yl]benzoic acid ,  3-[(3-Benzyl-1,2,3,4-tetrahydro-2,4-dioxoquinazolin)-1-yl]-N-methylbenzamide ,  3-[(3-Ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidin)-1-yl]benzoic acid methyl ester ,  3-[(3-Benzyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidin)-1-yl]benzoic acid methyl ester ,  3-[(3-Cyclopentylmethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidin)-1-yl]benzoic acid methyl ester ,  3-[(3-(Bicyclo[2.2.1]heptan-2-ylmethyl)-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidin)-1-yl]benzoic acid methyl ester

Terms in the title (6)： カルシウム ,  非依存 ,  阻害薬 ,  キナゾリン ,  ジオン ,  構造活性相関