Art

J-GLOBAL ID：200902044649429617   Reference number：92A0595805

1,3,6-Trisubstituted Indoles as Peptidoleukotriene Antagonists: Benefits of a Second, Polar, Pyrrole Substituent.

ペプチドロイコトリエンきっ抗薬としての1.3.6-三置換インドール類 第2の極性なピロール置換基の効果

Author (4)： BROWN F J (ICI Americas Inc., Delaware) ,  CRONK L A (ICI Americas Inc., Delaware) ,  AHARONY D (ICI Americas Inc., Delaware) ,  SNYDER D W (ICI Americas Inc., Delaware)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 35  Issue： 13  Page： 2419-2439  Publication year： Jun. 26, 1992 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： leukotriene antagonist ,...
Semi thesaurus term： indoles ,...

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JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (44)： 4-[6-Butoxycarbonylamino-1H-indol-1-ylmethyl]-3-methoxybenzoic acid ,  3-Methoxy-4-[[6-[(butoxycarbonyl)amino]-2-methyl-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-[(butoxycarbonyl)amino]-2,3-dimethyl-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-[(butoxycarbonyl)amino]-3-chloro-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-[(butoxycarbonyl)amino]-2,3-dibromo-1H-indol-1-yl]methyl]benzoic acid ,  4-[6-Cyclopentylacetylamino-1H-indol-1-ylmethyl]-3-methoxybenzoic acid ,  3-Methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-methyl-1H-indol-1-yl]methyl]benzoic acid ,  4-[6-(Cyclopentyloxycarbonylamino)-1H-indol-1-ylmethyl]-3-methoxybenzoic acid ,  3-Methoxy-4-[[6-[(cyclopentyloxy)carbonylamino]-3-chloro-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-[(cyclopentyloxy)carbonylamino]-3-acetyl-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-butyryl-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-[(cyclopentyloxy)carbonyl]-1H-indol-1-yl]methyl]benzoic acid ,  3-Methoxy-4-[[6-(2-cyclopentylethoxy)-1H-indol-1-yl]methyl]benzoic acid ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-methyl-1H-indol-1-yl]methyl]benzamide ,  4-[6-(Cyclopentyloxycarbonylamino)-1H-indol-1-ylmethyl]-3-methoxy-N-phenylsulfonylbenzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentyloxy)carbonylamino]-3-chloro-1H-indol-1-yl]methyl]benzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentyloxy)carbonylamino]-3-acetyl-1H-indol-1-yl]methyl]benzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-butyryl-1H-indol-1-yl]methyl]benzamide ,  4-[6-(Cyclopentylacetylamino)-1H-indol-1-ylmethyl]-3-methoxy-N-phenylsulfonylbenzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-[2-(methoxycarbonyl)ethyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-(2-carboxyethyl)-1H-indol-1-yl]methyl]benzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-[2-(methylaminocarbonyl)ethyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylacetyl)amino]-3-[2-(aminocarbonyl)ethyl]-1H-indol-1-yl]methyl]benzamide ,  N-(Phenylsulfonyl)-3-methoxy-4-[[1,2,3,4-tetrahydro-7-[(cyclohexylacetyl)amino]-9H-carbazol]-9-ylmethyl]benzamide ,  3-Methoxy-4-[[1-methyl-5-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-3-yl]methyl]benzoic acid ,  3-Methoxy-4-[[1-methyl-5-[(cyclopentylmethyl)aminocarbonyl]-1H-indazol-3-yl]methyl]benzoic acid ,  4-[5-(Cyclopentylacetylamino)-1-methyl-1H-indol-3-ylmethyl]-3-methoxybenzoic acid ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[1-methyl-5-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-3-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[1-methyl-5-[(cyclopentylmethyl)aminocarbonyl]-1H-indazol-3-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-methyl-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  4-[5-(Cyclopentylacetylamino)-1-methyl-1H-indol-3-ylmethyl]-3-methoxy-N-(2-methylphenylsulfonyl)benzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-[2-(methylcarbamoyl)ethyl]-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[1-[2-(diethylaminocarbonyl)ethyl]-5-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-3-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[1-[1-(dimethylaminocarbonyl)ethyl]-5-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-3-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[6-(2-cyclopentylethoxy)-1H-indol-1-yl]methyl]benzamide ,  N-[(Phenyl)sulfonyl]-3-methoxy-4-[[3-[2-(aminocarbonyl)ethyl]-6-(2-cyclopentylethoxy)-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-[2-(dimethylcarbamoyl)propyl]-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-[2-(diethylcarbamoyl)ethyl]-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-[2-(diethylcarbamoyl)ethenyl]-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-(3-morpholino-3-oxopropyl)-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-[3-oxo-3-(pyrrolidin-1-yl)propyl]-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide ,  N-[(2-Methylphenyl)sulfonyl]-3-methoxy-4-[[3-[3-oxo-3-(4,4-dimethylpiperidin-1-yl)propyl]-6-[(cyclopentylmethyl)aminocarbonyl]-1H-indol-1-yl]methyl]benzamide

Terms in the title (7)： ペプチド ,  ロイコトリエンきっ抗薬 ,  置換 ,  インドール類 ,  極性 ,  ピロール ,  置換基