Art

J-GLOBAL ID：200902046447884382   Reference number：91A0833833

Potent, Orally Active Imidazo[4,5-b]pyridine-Based Angiotensin II Receptor Antagonists.

活性かつ経口活性を有するイミダゾ[4,5-b]ピリミジン系アンギオテンシンII受容器きっ抗薬

Author (9)： MANTLO N B (Merck Sharp and Dohme Research Lab., New Jersey) ,  CHAKRAVARTY P K (Merck Sharp and Dohme Research Lab., New Jersey) ,  ONDEYKA D L (Merck Sharp and Dohme Research Lab., New Jersey) ,  SIEGL P K S (Merck Sharp and Dohme Research Lab., Pennsylvania) ,  CHANG R S (Merck Sharp and Dohme Research Lab., Pennsylvania) ,  LOTTI V J (Merck Sharp and Dohme Research Lab., Pennsylvania) ,  FAUST K A (Merck Sharp and Dohme Research Lab., Pennsylvania) ,  CHEN T-B (Merck Sharp and Dohme Research Lab., Pennsylvania) ,  GREENLEE W J (Merck Sharp and Dohme Research Lab., New Jersey)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 9  Page： 2919-2922  Publication year： Sep. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： angiotensin ,...
Semi thesaurus term： L-158809 ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Synthesis of drugs  (GV01030F)

Substance index (8)： 2-Propyl-3-[[2′-(2H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine ,  5-Methyl-2-propyl-3-[[2′-(2H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine ,  7-メチル-2-プロピル-3-[[2′-(2H-テトラゾール-5-イル)-1,1′-ビフェニル-4-イル]メチル]-3H-イミダゾ[4,5-b]ピリジン ,  2-Butyl-5,7-dimethyl-3-[[2′-(2H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine ,  5,7-Dimethyl-2-propyl-3-[[2′-(2H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine ,  L-158809 ,  Losartan potassium ,  Losartan carboxylic acid

Terms in the title (5)： 活性 ,  ピリミジン ,  アンギオテンシンII ,  受容器 ,  きっ抗薬