Art

J-GLOBAL ID：200902049637608925   Reference number：91A0464450

Quinazolineacetic acids and related analogues as aldose reductase inhibitors.

アルドースレダクターゼ阻害剤としてのキナゾリン酢酸およびその類似体

Author (2)： MALAMAS M S (Wyeth-Ayerst Research, New Jersey) ,  MILLEN J (Wyeth-Ayerst Research, New Jersey)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 4  Page： 1492-1503  Publication year： Apr. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： hydroquinazolines ,...

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JST classification (2)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Basic research of drugs acting on sensory organs  (GW04060K)

Substance index (52)： 1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-7-chloro-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6-chloro-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-5-chloro-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-8-fluoro-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6-iodo-2,4-dioxoquinazoline-3-acetic acid ,  1-(1-Phenylethyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-chloro-2,4-dioxoquinazoline-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-methoxy-2,4-dioxoquinazoline-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-methyl-2,4-dioxoquinazoline-3-acetic acid ,  1-(3,4-Difluorobenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1,2,3,4-Tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-Methyl-1,2,3,4-tetrahydro-6-chloro-2,4-dioxoquinazoline-3-acetic acid ,  1-(2-Propenyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-7-fluoro-2,4-dioxoquinazoline-3-acetic acid ,  1-Phenyl-1,2,3,4-tetrahydro-2,4-dioxoquinazoline-3-acetic acid ,  1-(3-Bromo-4-methoxybenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(2-Phenylethyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-Benzyl-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Methoxybenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Trifluoromethylbenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromobenzyl)-1,2,3,4-tetrahydro-6-bromo-2,4-dioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6-chloro-4-oxo-2-thioxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-6-chloro-4-oxoquinazoline-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-2-oxoquinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-6-chloro-3-carboxymethyl-3,4-dihydro-4-oxo-1H-2,1,3-benzothiadiazine 2-oxide ,  3-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-2-oxoquinazoline-1-acetic acid ,  3-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-chloro-4-oxo-2-thioxoquinazoline-1-acetic acid ,  3-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-chloro-2,4-dioxoquinazoline-1-acetic acid ,  3-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-6-chloro-4-oxoquinazoline-1-acetic acid ,  Tolrestat ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-5,6-dimethyl-2,4-dioxothieno[2,3-d]pyrimidine-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4,5,6,7,8-octahydro-2,4-dioxo[1]benzothieno[2,3-d]pyrimidine-3-acetic acid ,  3-(3,4-Dichlorobenzyl)-1,2,3,4,5,6,7,8-octahydro-2,4-dioxo[1]benzothieno[2,3-d]pyrimidine-1-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxothieno[3,2-d]pyrimidine-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-5,6-dimethyl-2,4-dioxopyrimidine-3-acetic acid ,  1-(3,4-Dichlorobenzyl)-1,2,3,4-tetrahydro-5-methyl-2,4-dioxo-6-phenylpyrimidine-3-acetic acid ,  6-Bromo-3,4-dihydro-2-methyl-4-oxoquinazoline-3-acetic acid ,  6-Bromo-3,4-dihydro-2-methyl-4-thioxoquinazoline-3-acetic acid ,  6-Bromo-3,4-dihydro-2-trifluoromethyl-4-oxoquinazoline-3-acetic acid ,  6-Bromo-3,4-dihydro-2-ethyl-4-oxoquinazoline-3-acetic acid ,  6-Bromo-3,4-dihydro-2-isopropyl-4-oxoquinazoline-3-acetic acid ,  6-Bromo-3,4-dihydro-4-oxoquinazoline-3-acetic acid ,  3,4-Dihydro-2-methyl-4-oxobenzo[g]quinazoline-3-acetic acid ,  1-(4-Bromo-2-fluorobenzyl)-2,3-dihydro-3-oxo-1H-indazole-2-acetic acid ,  2-(4-Bromo-2-fluorobenzyl)-2,3-dihydro-3-oxo-1H-indazole-1-acetic acid ,  2-(4-Bromo-2-fluorobenzyl)-5-nitro-2,3-dihydro-3-oxo-1H-indazole-1-acetic acid ,  2-(3,4-Dichlorobenzyl)-5-nitro-2,3-dihydro-3-oxo-1H-indazole-1-acetic acid ,  5-Chloro-2-(3,4-dichlorobenzyl)-2,3-dihydro-3-oxo-1H-indazole-1-acetic acid

Terms in the title (4)： アルドースレダクターゼ阻害剤 ,  キナゾリン ,  酢酸 ,  類似体