Art

J-GLOBAL ID：200902054130844078   Reference number：92A0532509

Studies on Cerebral Protective Agents. I. Novel 4-Arylpyrimidine Derivatives with Anti-anoxic and Anti-lipid Peroxidation Activities.

脳保護薬 I 抗低酸素症作用及び抗脂質過酸化作用をもつ新しい4-アリールピリミジン誘導体

Author (5)： KUNO A (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  SUGIYAMA Y (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  KATSUTA K (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  KAMITANI T (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  TAKASUGI H (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 40  Issue： 6  Page： 1452-1461  Publication year： Jun. 1992 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： pyrimidines ,...

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JST classification (2)： Pyrimidines  (CF07103W) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (44)： 2,6-Diphenyl-4-methylpyrimidine-5-carboxylic acid ethyl ester ,  4-(4-ピリジル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-(3-ピリジル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  2-Phenyl-4-(2-pyridinyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester ,  4-(4-ニトロフェニル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  2-Phenyl-4-methyl-6-(3-nitrophenyl)pyrimidine-5-carboxylic acid ethyl ester ,  4-(2-ニトロフェニル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-(3-クロロフェニル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-(3-シアノフェニル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-(4-シアノフェニル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-[4-(メトキシカルボニル)フェニル]-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-[3-(トリフルオロメチル)フェニル]-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-(3-メトキシフェニル)-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-[2-(4-クロロフェニルチオ)フェニル]-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  4-[2-[(4-クロロフェニル)メトキシ]フェニル]-2-フェニル-6-メチルピリミジン-5-カルボン酸エチル ,  5-Acetyl-6-methyl-2-phenyl-4-(4-pyridyl)pyrimidine ,  2,6-Dimethyl-4-(4-pyridyl)pyrimidine-5-carboxylic acid ethyl ester ,  2-Methyl-6-phenyl-4-(4-pyridyl)pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-(4-pyridyl)pyrimidine-5-carboxylic acid ,  6-Methyl-2-phenyl-4-(4-pyridyl)pyrimidin-5-ylcarbamic acid tert-butyl ester ,  6-Methyl-2-phenyl-4-(4-pyridyl)pyrimidin-5-amine ,  6-Methyl-2-phenyl-4-(4-pyridyl)pyrimidine-5-methanol ,  5,6-Dimethyl-2-phenyl-4-(4-pyridyl)pyrimidine ,  2-Phenyl-6-(hydroxymethyl)-4-(4-pyridyl)pyrimidine-5-carboxylic acid lactone ,  6-Methyl-2-phenyl-4-(3-nitrophenyl)pyrimidine-5-carboxylic acid methyl ester ,  6-Methyl-2-phenyl-4-(3-nitrophenyl)pyrimidine-5-carboxylic acid isopropyl ester ,  5-Acetyl-6-methyl-2-phenyl-4-(3-nitrophenyl)pyrimidine ,  6-Methyl-2-phenyl-4-(3-nitrophenyl)pyrimidine-5-carboxylic acid ,  6-Methyl-2-phenyl-4-(3-nitrophenyl)pyrimidin-5-ylcarbamic acid tert-butyl ester ,  6-Methyl-2-phenyl-4-(3-nitrophenyl)pyrimidin-5-amine ,  6-Methyl-2-phenyl-4-(4-pyridyl)pyridine-3,5-dicarboxylic acid diethyl ester ,  2,6-Dimethyl-4,4′-bipyridine-3,5-dicarboxylic acid diethyl ester ,  6-Methyl-2-phenyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid diethyl ester ,  2,6-Dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid diethyl ester ,  6-Methyl-2-phenyl-4-[4-hydroxy-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[4-acetoxy-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[6-chloro-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[4-chloro-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[4-hydroxy-5-methoxy-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[6-(methylthio)-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[6-(methylsulfinyl)-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[6-(methylsulfonyl)-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[6-[(4-chlorophenyl)methoxy]-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester ,  6-Methyl-2-phenyl-4-[2-[(4-chlorophenyl)methoxy]-3-nitrophenyl]pyrimidine-5-carboxylic acid ethyl ester

Reference (25)：

• 1) T. Takaya, H. Takasugi, A. Kuno, and Y. Sugiyama, European Patent 169712 (1986) [Chem. Abstr., 105, 172492q (1986)].
• 2) a) H.B. Demopoulos, E.S. Flamm, D.D. Pietronigro, and M.L. Seligman, Acta Physiol. Scand., Suppl. 492, 91 (1980)
• b) B.K. Siesjö, J. Cereb. Blood Flow Metabol., 1, 155 (1981)
• c) E. Cadenas, A. Boveris, C.I. Ragan, and A.O.M. Stoppani, Arch. Biochem. Biophys., 180, 248 (1977)
• d) A. Boveris and E. Cadenas, FEBS Lett., 54, 311 (1975)

Terms in the title (4)： 脳保護薬 ,  低酸素症 ,  脂質過酸化 ,  誘導体