Art

J-GLOBAL ID：200902057602772865   Reference number：91A0230398

Synthesis of water-soluble(aminoalkyl)camptothecin analogues: Inhibition of topoisomerase I and antitumor activity.

水溶性(アミノアルキル)カンプトテシン類似体の合成 トポイソメラーゼIの阻害および抗腫よう作用

Author (9)： KINGSBURY W D (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  BOEHM J C (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  JAKAS D R (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  HOLDEN K G (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  HECHT S M (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  GALLAGHER G (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  CARANFA M J (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  MCCABE F L (SmithKline Beechan Pharmaceuticals, Pennsylvania) ,  HERTZBERG R P (SmithKline Beechan Pharmaceuticals, Pennsylvania)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 1  Page： 98-107  Publication year： Jan. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： DNA topoisomerase I ,...
Semi thesaurus term： camptothecin

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (31)： Camptothecin ,  (20S)-10-Hydroxycamptothecin ,  Topotecan ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-morpholinomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(4-methyl-1-piperazinylmethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(N-methylphenylaminomethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-[4-(1-piperidinyl)-1-piperidinylmethyl]-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-cyclopropylaminomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-cyclohexylaminomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(2-hydroxyethylaminomethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(2-dimethylaminoethylaminomethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-trimethylaminiomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-formyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(2-dimethylaminoethoxymethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-ethoxymethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(2-dimethylaminoethylthiomethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-cyanomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4,9-dihydroxy-10-(2-aminoethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-dimethylaminomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-morpholinomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-9-cyano-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-9-aminomethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  9-Aminocamptothecin ,  (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-methyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  (4S)-4α-Ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-9-phosphonato-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline ,  4,12-Dihydro-9-cyanomethyl-4-ethyl-4-hydroxy-11-methyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  4,12-Dihydro-9-(2-aminoethyl)-4-ethyl-4-hydroxy-11-methyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  4,12-Dihydro-11-[2-[N-(benzyloxycarbonyl)methylamino]ethyl]-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  4,12-Dihydro-4-ethyl-4-hydroxy-11-(2-methylaminoethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  4,12-Dihydro-4,11-diethyl-4-hydroxy-9-[4-(1-piperidinyl)-1-piperidinylcarbonyloxy]-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione ,  4,12-Dihydro-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione

Terms in the title (7)： 水溶性 ,  アミノアルキル ,  カンプトテシン ,  類似体 ,  トポイソメラーゼI ,  阻害 ,  抗腫よう作用