Art

J-GLOBAL ID：200902064522910392   Reference number：91A0554639

Comparison of Cardiovascular Effects of a Novel Class Ic Antiarrhythmic Agent, NIK-244, with Those of Flecainide in Isolated Canine Heart Preparations Cross-Circulated with a Donor Dog.

供血犬で交差還流した摘出イヌ心臓標本における新規クラスIc抗不整脈薬NIK-244とフレカイニドの心血管作用の比較

Author (3)： SUGIYAMA A (Yamanashi Medical Coll., Yamanashi, JPN) ,  MOTOMURA S (Yamanashi Medical Coll., Yamanashi, JPN) ,  HASHIMOTO K (Yamanashi Medical Coll., Yamanashi, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 56  Issue： 1  Page： 1-12  Publication year： May. 1991 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： dog ,...
Semi thesaurus term： NIK-244 ,...

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JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (2)： Flecainide ,  NIK-244

Reference (15)：

• 1 Rosenshtraukh, L.V., Shugushev, K.K. and Smetnev, A.S.: Ethacizin: a new efficacious Soviet antiarrhythmic drug of the phenothiazine group. Am. Heart J. 112, 932-939 (1986)
• 2 Urthaler, F.U., Rosenshtraukh, L.V., Hageman, G.R., Anjukhovsky, E.P. and James, T.N.: Differential modulation of autonomic activity by ethmozin and ethacizin (analog of ethmozin) on the canine sinus node and atrioventricular junction. J. Am. Coll. Cardiol. 8, 86A-94A (1986)
• 3 Satoh, H., Ishii, M. and Hashimoto, K.: An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle. Br. J. Pharmacol. 98, 827-832 (1989)
• 4 Rosenshtraukh, L.V., Aniukhovsky, E.P., Beloshapko, G.G., Dremin, S.A., Chikharev, V.N., Lyskovtsev, V.V. and Senova, Z.P.: Decrease in fast inward sodium current as a possible cause of the antiarrhythmic effect of ethmozin, mexitil, and lidocaine in the late stage of experimental myocardial infarction. In Proceedings of Second USA-USSR Joint Symposium of Sudden Cardiac Death, Indianapolis, 1979, p. 119-137, Department of Health, Education and Welfare Publication, NIH (1980)
• 5 Hashimoto, K., Matsuzaki, T. and Haruno, A.: Antiarrhythmic plasma concentrations of NIK-244 on canine ventricular arrhythmias. J. Cardiovasc. Pharmacol. 14, 892-898 (1989)

Terms in the title (12)： 交差 ,  還流 ,  摘出 ,  イヌ ,  心臓 ,  標本 ,  クラス ,  IC ,  抗不整脈薬 ,  NIK-244 ,  フレカイニド ,  心血管作用