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J-GLOBAL ID：200902071353694657   Reference number：92A0777461

DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth.

細菌由来のDNAはインターフェロンを誘導しナチュラルキラー細胞を活性化し腫よう増殖を阻害するが,脊椎動物由来DNAにはその作用がない

Author (7)： YAMAMOTO S (National Inst. Health, Tokyo, JPN) ,  KATAOKA T (National Inst. Health, Tokyo, JPN) ,  TOKUNAGA T (National Inst. Health, Tokyo, JPN) ,  YAMAMOTO T (Japanese Foundation for AIDS Prevention, Tokyo, JPN) ,  SHIMADA S (Mitsui Pharmaceuticals Inc., Chiba, JPN) ,  KURAMOTO E (Mitsui Pharmaceuticals Inc., Chiba, JPN) ,  YANO O (Mitsui Pharmaceuticals Inc., Chiba, JPN)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 36  Issue： 9  Page： 983-997  Publication year： Sep. 1992 
JST Material Number： F0715A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Pseudomonas putida ,...
Semi thesaurus term： Mycobacterium bovis ,...

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JST classification (1)： Microorganism biochemistry  (EG03020N)

Reference (29)：

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• 4) Field, A.K., Tytell, A.A., Lampson, G.P., and Hilleman, M.R. 1967. Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc. Natl. Acad. Sci. U.S.A. 58: 1004-1010.
• 5) Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., and Taniguchi, T. 1989. Structurally similar but functionally distinct factors, IRF-1 and IRF-2 bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58: 729-739.

Terms in the title (9)： 細菌 ,  DNA ,  インターフェロン ,  誘導 ,  ナチュラルキラー細胞 ,  活性化 ,  腫よう増殖 ,  阻害 ,  脊椎動物