Art

J-GLOBAL ID：200902077382074208   Reference number：90A0875010

Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans.

4-(置換カルボニルアミノ)-2H-1-ベンゾピラン類の合成および抗高血圧作用

Author (8)： ASHWOOD V A (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  CASSIDY F (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  COLDWELL M C (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  EVANS J M (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  HAMILTON T C (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  HOWLETT D R (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  SMITH D M (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  STEMP G (SmithKline Beecham Pharmaceuticals, Essex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 33  Issue： 9  Page： 2667-2672  Publication year： Sep. 1990 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： hydrobenzopyrans ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Condensed derivatives of pyrane  (CF07093I)

Substance index (39)： (3S)-4-(2-Oxo-1-pyrrolidinyl)-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-(N-Acetylethylamino)-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-(N-Acetylmethylamino)-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-(N-Acetylisopropylamino)-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Acetylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Formylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Propionylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Pentanoylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Thioacetylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Acetylamino-3,4-dihydro-3β-acetyloxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Chloroacetylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Methoxyacetylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-4-Methylaminoacetylamino-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  4-Acetylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  4-Acetylamino-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-4-acetylamino-2,2-dimethyl-2H-1-benzopyran-3β-ol ,  (3S)-3,4-Dihydro-4-acetylamino-6-chloro-2,2-dimethyl-2H-1-benzopyran-3β-ol ,  (3S)-3,4-Dihydro-6-acetyl-4-acetylamino-2,2-dimethyl-2H-1-benzopyran-3β-ol ,  (3S)-3,4-Dihydro-4,7-bis(acetylamino)-6-nitro-2,2-dimethyl-2H-1-benzopyran-3β-ol ,  (3S)-3,4-Dihydro-4,6-bis(acetylamino)-7-nitro-2,2-dimethyl-2H-1-benzopyran-3β-ol ,  (3S)-3,4-Dihydro-4-acetylamino-6-bromo-7-nitro-2,2-dimethyl-2H-1-benzopyran-3β-ol ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-acetylamino-7-nitro-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-benzoylamino-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(2-naphthalenylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(2-pyridinylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-pyridinylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(1H-pyrrol-2-ylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(1H-indol-3-ylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(2-furanylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-furanylcarbonylamino)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-ureido-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-methylureido)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-[3-methyl(thioureido)]-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-butylureido)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-tert-butylureido)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-phenylureido)-2H-1-benzopyran-6-carbonitrile ,  (3S)-3,4-Dihydro-3β-hydroxy-2,2-dimethyl-4-(3-trichloroacetylureido)-2H-1-benzopyran-6-carbonitrile ,  2-[[(3S)-3,4-Dihydro-6-cyano-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran]-4-ylamino]glyoxylic acid ethyl ester ,  N-[[(3S)-6-Cyano-3,4-dihydro-3β-hydroxy-2,2-dimethyl-2H-1-benzopyran]-4-yl]carbamic acid ethyl ester

Terms in the title (3)： 置換 ,  2H-1-ベンゾピラン ,  高血圧