Art

J-GLOBAL ID：200902077841682593   Reference number：90A0562580

Pharmacological studies on (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxolmidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities.

新規ACE阻害薬,(4S)-1-メチル-1-{(2S)-2-[N-((1S)-1-エトキシカルボニル-3-フェニルプロピル)アミノ]プロピオニル}-2-オキソイミダゾリジン-4-カルボン酸塩酸(TA-6366)の薬理効果 I ACE阻害と抗高血圧活性

Author (4)： KUBO M (Tanabe Seiyaku Co., Ltd., Osaka, JPN) ,  KATO J (Tanabe Seiyaku Co., Ltd., Osaka, JPN) ,  OCHIAI T (Tanabe Seiyaku Co., Ltd., Osaka, JPN) ,  ISHIDA R (Tanabe Seiyaku Co., Ltd., Osaka, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 53  Issue： 2  Page： 201-210  Publication year： Jun. 1990 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： angiotensin converting enzyme inhibitor ,...
Semi thesaurus term： TA-6366 ,...

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JST classification (1)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Reference (16)：

• 1) Hayashi, K., Nunami, K., Kato, J., Yoneda, N., Kubo, M., Ochiai, T. and Ishida, R.: Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1 -alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives. J. Med. Chem. 32, 289-297 (1989)
• 2) Patchett, A.A., Harris, E., Tristram, E.W., Wyvratt, M.J., Wu, M.T, Taub, D., Peterson, E.R., Ikeler, T.J., Broeke, J.T., Payne, L.G., Ondeyka, D.L., Thorsett, E.D., Greenlee, W.J., Lohr, N.S., Hoffsommer, R.D., Joshua, H., Ruyle, W.V., Rothrock, J.W., Aster, S.D., Maycock, A.L., Robinson, F.M. and Hirschmann, R.: A new class of converting enzyme inhibitors. Nature 288, 280-283 (1980)
• 3) Cushman, D.W., Cheung, H.S., Sabo, E.F. and Ondetti, M.A.: Design of potent competitive inhibitors of angiotensin converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry 16, 5484-5491 (1977)
• 4) Oshima, G., Gecse, A. and Erdos, E.G.: Angiotensin I converting enzyme of the kidney cortex. Biochim. Biophys. Acta 350, 26-37 (1974)
• 5) Yang, H.Y.T., Erdos, E.G. and Levin, Y.: Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme) J. Pharmacol. Exp. Ther. 177, 291-300 (1971 )

Terms in the title (10)： ACE阻害薬 ,  2-オキソイミダゾリジン ,  カルボン酸 ,  塩酸 ,  TA-6366 ,  薬理効果 ,  ACE ,  阻害 ,  高血圧 ,  活性