Art

J-GLOBAL ID：200902078861299768   Reference number：91A0160710

Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl]ester derivatives.

新奇な1,4-ジヒドロピリジン系カルシウムきっ抗薬 II 3-[4-(置換アミノ)フェニルアルキル]エステル誘導体の合成および抗高血圧活性

Author (9)： AHIMORI A (Green Cross Corp., Osaka, JPN) ,  ONO T (Green Cross Corp., Osaka, JPN) ,  INOUE Y (Green Cross Corp., Osaka, JPN) ,  MORIMOTO S (Green Cross Corp., Osaka, JPN) ,  EDA M (Green Cross Corp., Osaka, JPN) ,  UCHIDA T (Green Cross Corp., Osaka, JPN) ,  OHTAKI Y (Green Cross Corp., Osaka, JPN) ,  FUJINO Y (Green Cross Corp., Osaka, JPN) ,  YOKOYAMA K (Green Cross Corp., Osaka, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 39  Issue： 1  Page： 91-99  Publication year： Jan. 1991 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： hydropyridines ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Pyridines  (CF07095Q)

Substance index (13)： 2,6-Dimethyl-4-(4-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-dimethylaminophenyl]ethyl] ester ,  2,6-Dimethyl-4-[2-(trifluoromethyl)-3-pyridyl]-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-dimethylaminophenyl]ethyl] ester ,  2,6-Dimethyl-4-(4-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-dibenzylaminophenyl]ethyl] ester ,  2,6-Dimethyl-4-[2-(trifluoromethyl)-3-pyridyl]-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-dibenzylaminophenyl]ethyl] ester ,  AE-0047 ,  2,6-Dimethyl-4-(4-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[(4-benzhydrylpiperazin)-1-yl]phenyl]ethyl] ester ,  2,6-Dimethyl-4-[2-(trifluoromethyl)-3-pyridyl]-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[(4-benzhydrylpiperazin)-1-yl]phenyl]ethyl] ester ,  2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[3-[4-[(4-benzhydrylpiperazin)-1-yl]phenyl]propyl] ester ,  2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[[4-[bis(4-fluorophenyl)methyl]piperazin]-1-yl]phenyl]ethyl] ester ,  2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[(4-benzhydrylpiperidin)-1-yl]phenyl]ethyl] ester ,  2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[(1-benzhydrylpiperidin)-4-yl]phenyl]ethyl] ester ,  2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[(methyl)[2-[(methyl)(benzhydryl)amino]ethyl]amino]phenyl]ethyl] ester ,  2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[4-[(4-benzhydrylpiperazin)-1-yl]-2-butenyl] ester

Reference (17)：

• 1) Part I: A. Ashimori, T. Ono, T. Uchida, Y. Ohtaki, C. Fukaya, M. Watanabe, and K. Yokoyama, Chem. Pharm. Bull., 38, 2446 (1990).
• 2) F. Bossert, E. Wehinger, K. Stoepel, W. Vater, and S. Kazda, Ger. Patent 2508181 (1976) [Chem. Absir., 86, 29638a (1977)].
• 3) J.M. Van Nueten and P.A.J. Janssen, Arch. Int. Pharmacodyn. Ther., 204, 37 (1973)
• L.K.C. Desmedt, C.J.E. Niemegeers, and P.A.J. Janssen, Arzneim. -Forsch., 25, 1408 (1975).
• 4) K. Meguro, M. Aizawa, T. Sohda, Y. Kawamatsu, and A. Nagaoka, Chem. Pharm. Bull., 33, 3787 (1985).

Terms in the title (6)： ジヒドロピリジン ,  カルシウムきっ抗薬 ,  置換アミノ ,  エステル誘導体 ,  高血圧 ,  活性