Art

J-GLOBAL ID：200902080475196053   Reference number：90A0920164

New strategy for discovery of enzyme inhibitors: Screening with intact mammalian cells or intact microorganisms having special functions.

酵素阻害剤の発見の新規方策 特殊機能を有するほ乳動物無傷細胞または微生物無傷細胞を用いた検索

Author (2)： TOMODA H (Kitasato Inst., Tokyo, JPN) ,  OMURA S (Kitasato Inst., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 43  Issue： 10  Page： 1207-1222  Publication year： Oct. 1990 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： enzyme inhibitor ,...
Semi thesaurus term： screening method

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JST classification (1)： Research methods  (GV01020U)

Reference (81)：

• 1) UMEZAWA, H.: Structures and activities of protease inhibitors of microbial origin. In Methods in Enzymology. Vol. 45. Ed., L. LORAND, pp. 678-695, Academic Press, 1976
• 2) UMEZAWA, H.: Low molecular weight enzyme inhibitors and immunomodifiers. In Actinomycetes in Biotechnology. Ed., M. GOODFELLOW et al., pp. 285-326, Academic Press, 1988
• 3) ENDO, A.: Biological and pharmacological activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Trends Biochem. Sci. 16: 10-12, 1981
• 4) UMEZAWA, H.: Low-molecular-weight enzyme inhibitors of microbial origin. Ann. Rev. Microbiol. 36: 75-99, 1982
• 5) SCHMIDT, D. D.; W. FROMMER, B. JUNGE, L. MULLER, W. WINGENDER & E. TRUSHEIT: α-Glucosidase inhibitors, new complex oligosaccharides of microbial origin. Naturwissenschaften 64: 535-536, 1977

Terms in the title (8)： 酵素阻害剤 ,  発見 ,  方策 ,  ほ乳動物 ,  無傷 ,  細胞 ,  微生物 ,  検索