Art

J-GLOBAL ID：200902084412615558   Reference number：91A0464414

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

キヌレン酸誘導体,興奮性アミノ酸きっ抗作用の構造活性相関およびN-メチル-D-アスパルテートレセプターのグリシン部位における活性のある選択的なアンタゴニストの同定

Author (9)： LEESON P D (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  BAKER R (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  CARLING R W (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  CURTIS N R (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  MOORE K W (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  FOSTER A C (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  DONALD A E (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  KEMP J A (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  MARSHALL G R (Merck Sharp and Dohme Research Lab., Essex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 4  Page： 1243-1252  Publication year： Apr. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： hydroquinolines ,...

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JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (75)： Transtorine ,  5-Chloro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Chloro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  Ageloline A ,  8-Chloro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  DCKA ,  5,6,7-Trichloro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Fluoro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Trifluoromethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Ethenyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Propyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Isopropyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Butyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Hydroxy-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Methoxy-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Cyano-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Fluoro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  Caelestine A ,  7-Iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Trifluoromethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Ethenyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Propyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Isopropyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Butyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Acetyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Methoxy-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Benzyloxy-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Methylthio-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Nitro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dibromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Bromo-7-methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Bromo-7-ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Bromo-5-methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Bromo-5-ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dimethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Iodo-5-methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Iodo-7-methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Chloro-5-ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Chloro-7-ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Chloro-5-iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Chloro-7-iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dinitro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Bis(trifluoromethyl)-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Fluoro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Trifluoromethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Methylthio-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Methoxy-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  6-Nitro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dichloro-1-methyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dichloro-4-methoxyquinoline-2-carboxylic acid ,  (3,5-Dichlorophenylamino)acetic acid ,  N-(3,5-Dichlorophenyl)oxamidic acid ,  6-Chloro-1H-benzimidazole-2-carboxylic acid ,  Quinoxaline-2,3-diol ,  5-Chloroquinoxaline-2,3(1H,4H)-dione ,  6-Chloro-1,4-dihydroquinoxaline-2,3-dione ,  5,7-Dichloroquinoxaline-2,3(1H,4H)-dione ,  6,7-Dichloroquinoxaline-2,3(1H,4H)-dione ,  6,7-Dimethylquinoxaline-2,3(1H,4H)-dione ,  6-Nitroquinoxaline-2,3-diol ,  DNQX ,  1,6,7-Trimethylquinoxaline-2,3(1H,4H)-dione ,  1,4,6,7-Tetramethylquinoxaline-2,3(1H,4H)-dione ,  6,7-Dimethyl-3-methoxyquinoxalin-2(1H)-one ,  6,7-Dimethyl-2,3-dimethoxyquinoxaline

Terms in the title (9)： キヌレン酸 ,  誘導体 ,  興奮性アミノ酸 ,  きっ抗作用 ,  構造活性相関 ,  グリシン ,  活性 ,  アンタゴニスト ,  同定