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J-GLOBAL ID：200902084579351170   Reference number：92A0379016

Synthetic Oligonucleotides with Particular Base Sequences from the cDNA Encoding Proteins of Mycobacterium bovis BCG Induce Interferons and Activate Natural Killer Cells.

ウシ型結核菌BCG由来蛋白質をコードするcDNAの塩基配列を持つ合成オリゴヌクレオチドは,インターフェロンを誘導しNK細胞を活性化する

Author (7)： TOKUNAGA T (National Inst. Health (NIH), Tokyo, JPN) ,  YANO O (Mitsui Pharmaceutical Inc., Chiba, JPN) ,  KURAMOTO E (Mitsui Pharmaceutical Inc., Chiba, JPN) ,  KIMURA Y (Mitsui Pharmaceutical Inc., Chiba, JPN) ,  YAMAMOTO T (National Inst. Health (NIH), Tokyo, JPN) ,  KATAOKA T (National Inst. Health (NIH), Tokyo, JPN) ,  YAMAMOTO S (National Inst. Health (NIH), Tokyo, JPN)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 36  Issue： 1  Page： 55-66  Publication year： Jan. 1992 
JST Material Number： F0715A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： Mycobacterium bovis ,...

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JST classification (1)： Microorganism biochemistry  (EG03020N)

Reference (14)：

• 1) Agrawal, A., Ikeuchi, T., Sun, D., Sarin, P.S., Konopka, A., Maizel, J., and Zamecnik, P.C. 1989. Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligonucleotides and their phosphorothioate analoques. Proc. Natl. Acad. Sci. U.S.A. 86: 7790-7794.
• 2) Graeve, L., Goemann, W., Foldi, P., and Kruppa, J. 1982. Fractionation of biologically active messenger RNAs by HPLC gel filtration. Biochem. Biophys. Res. Comm. 107: 1559-1565.
• 3) Ishiwara, K., Ikeda, S., Arao, T., and Matsunaka, M. 1988. A pilot study on the effect of intralesionally injected MY-1 against malignancies of skin. Skin Cancer 3: 115-123 (in Japanese).
• 4) Kuramoto, E., Toizumi, S., Shimada, S., and Tokunaga, T. 1989. In situ infiltration of natural killer-like cells induced by intradermal injection of the nucleic acid fraction from BCG. Microbiol. Immunol. 33: 929-940.
• 5) Mashiba, H., Matsunaga, K., Tomoda, H., Furusawa, M., Jimi, S., and Tokunaga, T. 1988. In vitro augmentation of NK activity of peripheral blood cells from cancer patients by a DNA fraction from M. bovis BCG. Jpn. J. Med. Sci. Biol. 41: 197-202.

Terms in the title (9)： ウシ型結核菌BCG ,  蛋白質 ,  cDNA ,  塩基配列 ,  オリゴヌクレオチド ,  インターフェロン ,  誘導 ,  NK細胞 ,  活性化