Art

J-GLOBAL ID：200902090379988300   Reference number：93A0072641

Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists.

立体配座的に制限されたタキキニン類似体 活性かつ高い選択性を有するNK-2受容体作動薬

Author (9)： DEAL M J (Glaxo Group Research, Middlesex, GBR) ,  HAGAN R M (Glaxo Group Research, Hertfordshire, GBR) ,  IRELAND S J (Glaxo Group Research, Hertfordshire, GBR) ,  JORDAN C C (Glaxo Group Research, Hertfordshire, GBR) ,  MCELROY A B (Glaxo Group Research, Middlesex, GBR) ,  PORTER B (Glaxo Group Research, Middlesex, GBR) ,  ROSS B C (Glaxo Group Research, Middlesex, GBR) ,  STEPHENS-SMITH M (Glaxo Group Research, Middlesex, GBR) ,  WARD P (Glaxo Group Research, Middlesex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 35  Issue： 22  Page： 4195-4204  Publication year： Oct. 30, 1992 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： tachykinin ,...
Semi thesaurus term： ニューロキニン受容体作動薬 ,...

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JST classification (1)： Drugs acting on autonomic nervous system in general  (GW05010O)

Substance index (16)： N-(5-Aminopentanoyl)-L-Phe-L-Val-Gly-L-Leu-L-Met-NH₂ ,  N-(5-Aminovaleryl)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH₂ ,  N-(5-Aminovaleryl)-L-Phe-L-Phe-L-Pro-L-Leu-L-Met-NH₂ ,  N-(5-Aminovaleryl)-L-Phe-L-Phe-D-Pro-L-Leu-L-Met-NH₂ ,  L-Lys-L-Asp-L-Ser-L-Phe-L-Val-Gly-L-Leu-L-Met-NH₂ ,  L-Lys-L-Asp-L-Ser-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH₂ ,  N-[(2S)-2-[3α-[[N-(5-Aminopentanoyl)-L-Phe-L-Phe-]amino]-2-oxo-1-pyrrolidinyl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[3α-[[L-Lys-L-Asp-L-Ser-L-Phe-L-Val-]Amino]-2-oxo-1-pyrrolidinyl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[3α-[[N²-Acetyl-L-Lys-L-Asp-L-Ser-L-Phe-L-Val-]amino]-2-oxo-1-pyrrolidinyl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[[(3aβ,6aβ)-1-[N-(5-Aminopentanoyl)-L-Phe-L-Phe-]-6-oxooctahydropyrrolo[3,4-b]pyrrol]-5-yl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2R)-2-[[(3aβ,6aβ)-1-[N-(5-Aminopentanoyl)-L-Phe-L-Phe-]-6-oxooctahydropyrrolo[3,4-b]pyrrol]-5-yl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[[(3aβ,6aβ)-1-(L-Lys-L-Asp-L-Ser-L-Phe-L-Val-)-6-Oxooctahydropyrrolo[3,4-b]pyrrol]-5-yl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[[(3aβ,6aβ)-1-(L-Lys-L-Asp-L-Ser-L-Phe-L-Phe-)-6-Oxooctahydropyrrolo[3,4-b]pyrrol]-5-yl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[(5R)-1-[N-(5-Aminopentanoyl)-L-Phe-L-Phe-]-6-oxo-1,7-diazaspiro[4.4]nonan-8-yl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2S)-2-[[(3aβ,6aα)-1-[N-(5-Aminopentanoyl)-L-Phe-L-Phe-]-6-oxooctahydropyrrolo[3,4-b]pyrrol]-5-yl]-4-methylpentanoyl]-L-Met-NH₂ ,  N-[(2R)-2-[[(3aβ,6aα)-1-[N-(5-Aminopentanoyl)-L-Phe-L-Phe-]-6-oxooctahydropyrrolo[3,4-b]pyrrol]-5-yl]-4-methylpentanoyl]-L-Met-NH₂

Terms in the title (8)： 立体配座 ,  制限 ,  タキキニン ,  類似体 ,  活性 ,  選択性 ,  受容体 ,  作動薬