Art

J-GLOBAL ID：200902092775174645   Reference number：91A0833806

Synthesis, Ligand Binding, QSAR, and CoMFA Study of 3β-(p-Substituted phenyl)tropane-2β-carboxylic Acid Methyl Esters.

3β-(p-置換フェニル)トロパン-2β-カルボン酸メチルエステルの合成,リガンド結合,QSAR,およびCoMFA研究

Author (8)： CARROLL F I (Research Triangle Inst., North Carolina) ,  GAO Y (Research Triangle Inst., North Carolina) ,  RAHMAN M A (Research Triangle Inst., North Carolina) ,  ABRAHAM P (Research Triangle Inst., North Carolina) ,  PARHAM K (Research Triangle Inst., North Carolina) ,  LEWIN A H (Research Triangle Inst., North Carolina) ,  BOJA J W (National Inst. Drug Abuse, Maryland) ,  KUHAR M J (National Inst. Drug Abuse, Maryland)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 9  Page： 2719-2725  Publication year： Sep. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： tropane alkaloid ,...
Semi thesaurus term： bridged compound ,...

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JST classification (2)： Synthesis of drugs  (GV01030F) ,  Basic research of local anesthetics  (GW04020S)

Substance index (16)： Cocaine ,  (1β,5β,8-anti)-8-Methyl-3β-[phenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-3β-(4-Fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-3β-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-methylphenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-trifluoromethylphenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-methoxyphenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-nitrophenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-(4-aminophenyl)-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-(2-carbamoyloxyethyl)phenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-(aminocarbonylmethyl)phenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-(2-aminocarbonylethyl)phenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-bromophenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-iodophenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-[4-azidophenyl]-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ,  (1β,5β,8-anti)-8-Methyl-3β-(2-thienyl)-8-azabicyclo[3.2.1]octane-2β-carboxylic acid methyl ester

Terms in the title (8)： 置換フェニル ,  トロパン ,  カルボン酸 ,  メチルエステル ,  リガンド結合 ,  QSAR ,  CoMFA ,  研究